Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   FD735_RS05525 Genome accession   NZ_CP040231
Coordinates   1044726..1045433 (-) Length   235 a.a.
NCBI ID   WP_139658686.1    Uniprot ID   A0A5B7Y692
Organism   Streptococcus sp. 1643     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1039726..1050433
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FD735_RS05505 (FD735_05505) - 1041320..1041667 (+) 348 WP_139658684.1 thioredoxin -
  FD735_RS05510 (FD735_05510) - 1041705..1042478 (-) 774 WP_084943882.1 ion transporter -
  FD735_RS05515 (FD735_05515) vicX 1042573..1043382 (-) 810 WP_084943449.1 MBL fold metallo-hydrolase Regulator
  FD735_RS05520 (FD735_05520) micB 1043375..1044733 (-) 1359 WP_139658685.1 cell wall metabolism sensor histidine kinase VicK Regulator
  FD735_RS05525 (FD735_05525) micA 1044726..1045433 (-) 708 WP_139658686.1 response regulator YycF Regulator
  FD735_RS05530 (FD735_05530) mutY 1045490..1046668 (-) 1179 WP_139658687.1 A/G-specific adenine glycosylase -
  FD735_RS05535 (FD735_05535) pta 1046751..1047725 (-) 975 WP_033629713.1 phosphate acetyltransferase -
  FD735_RS05540 (FD735_05540) - 1047769..1048665 (-) 897 WP_139658688.1 RluA family pseudouridine synthase -
  FD735_RS05545 (FD735_05545) - 1048662..1049480 (-) 819 WP_139658689.1 NAD kinase -
  FD735_RS05550 (FD735_05550) - 1049464..1050135 (-) 672 WP_000151556.1 GTP pyrophosphokinase family protein -

Sequence

Protein


Download         Length: 235 a.a.        Molecular weight: 26971.83 Da        Isoelectric Point: 4.6177

>NTDB_id=362649 FD735_RS05525 WP_139658686.1 1044726..1045433(-) (micA) [Streptococcus sp. 1643]
MKKILIVDDEKPISDIIKFNMAKEGYEVVTAFNGREAIELFEAEQPDIIILDLMLPEIDGLEVAKAIRKTSSVPIIMLSA
KDSELDKVIGLELGADDYVTKPFSNRELQARVKALLRRTDLVSVDSQESDEKKTQPLQIGDLEIVPDAYVAKKYGEELDL
THREFELLYHLASHIGQVITREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMRNND

Nucleotide


Download         Length: 708 bp        

>NTDB_id=362649 FD735_RS05525 WP_139658686.1 1044726..1045433(-) (micA) [Streptococcus sp. 1643]
ATGAAAAAAATATTAATTGTAGATGATGAGAAACCAATCTCAGATATTATTAAGTTTAATATGGCCAAGGAAGGTTATGA
AGTCGTTACAGCCTTCAATGGTCGTGAGGCAATCGAGCTATTTGAAGCTGAGCAACCGGATATTATTATCCTCGACTTGA
TGCTACCTGAAATTGATGGTTTAGAAGTTGCTAAAGCTATTCGTAAGACTAGTAGCGTGCCGATTATCATGCTATCAGCT
AAGGATAGCGAGCTTGACAAGGTTATTGGTTTAGAGTTAGGTGCAGACGATTATGTTACAAAACCTTTCTCAAACCGTGA
GTTGCAAGCACGTGTTAAGGCTCTCCTTCGTCGTACAGACCTGGTTTCTGTGGATAGCCAAGAGTCCGATGAGAAGAAGA
CGCAGCCTTTACAAATTGGTGATTTGGAAATCGTTCCAGATGCTTACGTGGCTAAGAAATATGGTGAGGAATTAGATTTG
ACCCACCGTGAGTTTGAACTCTTGTATCACTTGGCATCTCATATTGGACAAGTGATTACACGTGAACACTTGCTTGAGAC
TGTATGGGGTTATGACTATTTTGGTGATGTTCGTACTGTGGACGTGACCATTAGACGCTTGCGTGAAAAGATCGAAGACA
CACCAAGCCGTCCAGAGTACATTCTCACACGTCGTGGTGTTGGATACTATATGAGAAATAATGATTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(155-230)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5B7Y692

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

91.88

99.574

0.915
  vicR Streptococcus mutans UA159

77.021

100

0.77
  covR Streptococcus salivarius strain HSISS4

43.723

98.298

0.43
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.29

98.298

0.426
  scnR Streptococcus mutans UA159

37.179

99.574

0.37

Multiple sequence alignment