Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   FD735_RS03930 Genome accession   NZ_CP040231
Coordinates   724036..724710 (+) Length   224 a.a.
NCBI ID   WP_000590635.1    Uniprot ID   A0A139R176
Organism   Streptococcus sp. 1643     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 719036..729710
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FD735_RS03910 (FD735_03910) - 719496..719996 (+) 501 WP_125390973.1 NUDIX hydrolase -
  FD735_RS03915 (FD735_03915) - 719974..720822 (+) 849 WP_139658532.1 putative PEP-binding protein -
  FD735_RS03920 (FD735_03920) - 720819..721259 (+) 441 WP_084921940.1 ASCH domain-containing protein -
  FD735_RS03925 (FD735_03925) - 721380..723926 (+) 2547 WP_139658533.1 M1 family metallopeptidase -
  FD735_RS03930 (FD735_03930) ciaR 724036..724710 (+) 675 WP_000590635.1 two-component system response regulator CiaR Regulator
  FD735_RS03935 (FD735_03935) ciaH 724700..726037 (+) 1338 WP_139658534.1 cell wall metabolism sensor histidine kinase WalK Regulator
  FD735_RS03940 (FD735_03940) - 726103..726387 (-) 285 WP_139658535.1 DUF3270 domain-containing protein -
  FD735_RS03945 (FD735_03945) - 726773..727828 (+) 1056 WP_139658536.1 ABC transporter permease -
  FD735_RS03950 (FD735_03950) - 727842..728522 (+) 681 WP_139658537.1 ABC transporter ATP-binding protein -
  FD735_RS03955 (FD735_03955) - 728648..729577 (+) 930 WP_139658538.1 peptidase U32 family protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25465.26 Da        Isoelectric Point: 4.2660

>NTDB_id=362641 FD735_RS03930 WP_000590635.1 724036..724710(+) (ciaR) [Streptococcus sp. 1643]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGDVVVNLSTNEVKVEDTPVELLGKEFELLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTAFAENLQTLRSVGYILKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=362641 FD735_RS03930 WP_000590635.1 724036..724710(+) (ciaR) [Streptococcus sp. 1643]
ATGATAAAAATCTTATTAGTAGAAGATGACCTGGGCCTGTCAAACTCAGTATTTGACTTTTTGGATGATTTTGCAGATGT
CATGCAGGTCTTTGATGGAGAAGAGGGGCTCTACGAAGCAGAAAGTGGTGTTTATGACTTGATTCTGCTTGACCTCATGT
TGCCTGAAAAAAATGGCTTCCAAGTTTTGAAAGAATTGCGTGAAAAAGGAATTACAACTCCTGTCCTTATCATGACTGCT
AAGGAAAGTTTGGATGACAAGGGGCATGGATTTGAATTGGGAGCGGATGACTACCTCACCAAACCTTTCTACCTAGAAGA
ACTCAAAATGCGGATTCAAGCCCTTCTCAAACGTTCAGGCAAGTTTAACGAAAATACCTTGACCTATGGGGATGTTGTCG
TCAACCTTTCAACGAATGAAGTAAAAGTGGAAGATACGCCTGTGGAACTGCTCGGAAAAGAGTTTGAGTTATTGGTTTAC
TTCCTTCAAAATCAAAATGTCATTCTTCCCAAGACACAAATTTTTGATCGTCTATGGGGATTTGATAGCGATACGACTAT
TTCCGTTGTAGAAGTCTATGTTTCAAAAGTTCGTAAGAAATTGAAGGGGACAGCCTTTGCTGAAAATCTTCAAACCTTGC
GTAGTGTCGGGTATATTTTAAAAGATGTTCAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A139R176

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae TIGR4

97.321

100

0.973
  ciaR Streptococcus pneumoniae D39

97.321

100

0.973
  ciaR Streptococcus pneumoniae R6

97.321

100

0.973
  ciaR Streptococcus pneumoniae Rx1

97.321

100

0.973
  ciaR Streptococcus mutans UA159

87.5

100

0.875
  vicR Streptococcus mutans UA159

36.481

100

0.379
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.283

100

0.366

Multiple sequence alignment