Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   FD735_RS03935 Genome accession   NZ_CP040231
Coordinates   724700..726037 (+) Length   445 a.a.
NCBI ID   WP_139658534.1    Uniprot ID   A0A5B7Y5I8
Organism   Streptococcus sp. 1643     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 719700..731037
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FD735_RS03915 (FD735_03915) - 719974..720822 (+) 849 WP_139658532.1 putative PEP-binding protein -
  FD735_RS03920 (FD735_03920) - 720819..721259 (+) 441 WP_084921940.1 ASCH domain-containing protein -
  FD735_RS03925 (FD735_03925) - 721380..723926 (+) 2547 WP_139658533.1 M1 family metallopeptidase -
  FD735_RS03930 (FD735_03930) ciaR 724036..724710 (+) 675 WP_000590635.1 two-component system response regulator CiaR Regulator
  FD735_RS03935 (FD735_03935) ciaH 724700..726037 (+) 1338 WP_139658534.1 cell wall metabolism sensor histidine kinase WalK Regulator
  FD735_RS03940 (FD735_03940) - 726103..726387 (-) 285 WP_139658535.1 DUF3270 domain-containing protein -
  FD735_RS03945 (FD735_03945) - 726773..727828 (+) 1056 WP_139658536.1 ABC transporter permease -
  FD735_RS03950 (FD735_03950) - 727842..728522 (+) 681 WP_139658537.1 ABC transporter ATP-binding protein -
  FD735_RS03955 (FD735_03955) - 728648..729577 (+) 930 WP_139658538.1 peptidase U32 family protein -
  FD735_RS03960 (FD735_03960) rpiA 729683..730366 (+) 684 WP_139658539.1 ribose-5-phosphate isomerase RpiA -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 50804.51 Da        Isoelectric Point: 9.5838

>NTDB_id=362642 FD735_RS03935 WP_139658534.1 724700..726037(+) (ciaH) [Streptococcus sp. 1643]
MFNKLKKTWYADDFSYFIRNFGVFTLIFSAMTLIILQVMHSSLYTSVDEKLQALSSSPQAVIQLALNRATEEVKDIQPAT
ADASKAEIKPNVSSNTEVLLFDKDFNQLLLGNRFLGLDKIKLDKKELNHIRQIQVFNSYGQEETYRMVLMETNSSTVSSN
VKYAAVLINTSQLEQISQNHEHLIVVVMASFWLLSLIASVYLARVSVKPLLESMQKQKSFVENASHELRTPLAVLQNRLE
NLFRKPEATIMESSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPEIAEVSPQFLKTTFANYELIASENDRIFEYENRI
YRPFMTDQLLLKQLMTILFDNAIKYTEEDGKIEFVVHATDRHLYLTVTDNGIGISAADKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALRGTISVKDNKPRGTIFEVKIAIQSPSKRKNK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=362642 FD735_RS03935 WP_139658534.1 724700..726037(+) (ciaH) [Streptococcus sp. 1643]
ATGTTCAATAAACTAAAAAAAACATGGTATGCGGATGATTTCAGCTATTTCATTCGAAACTTCGGAGTGTTCACCCTGAT
TTTCTCTGCTATGACCTTGATTATCCTTCAGGTCATGCACTCGAGTCTCTACACTTCTGTAGATGAAAAACTCCAAGCCC
TTAGTAGTAGTCCTCAAGCTGTTATCCAGTTAGCCCTTAATCGGGCAACTGAGGAAGTCAAGGATATTCAACCAGCAACA
GCGGATGCCAGCAAGGCTGAAATCAAGCCCAATGTTAGCTCCAATACAGAAGTTTTGCTTTTTGACAAGGATTTTAACCA
ACTCTTACTGGGTAATCGCTTTTTAGGCTTGGACAAGATCAAACTGGACAAGAAAGAGTTGAATCATATTCGGCAAATCC
AAGTTTTCAACAGCTATGGTCAGGAAGAAACCTATCGAATGGTCTTGATGGAAACCAACTCTTCCACCGTATCAAGTAAT
GTCAAATATGCGGCGGTTCTAATCAATACCAGCCAGCTTGAGCAAATCAGCCAAAATCACGAGCATTTAATTGTTGTAGT
CATGGCTAGTTTCTGGCTCCTGTCTTTAATTGCTAGTGTTTACCTGGCACGTGTCAGTGTCAAACCGCTACTGGAAAGCA
TGCAAAAGCAGAAGTCCTTTGTTGAAAATGCGAGTCACGAACTGAGAACGCCTTTGGCCGTTTTACAAAATCGTTTAGAA
AATCTCTTTCGAAAACCAGAGGCAACCATCATGGAATCCAGCGAAAGTATCGCTTCCAGTCTTGAAGAGGTTCGCAACAT
GCGCTTCCTCACGACCAATCTTCTCAACCTTGCACGTCGAGATGATGGAATTAAACCAGAAATAGCAGAAGTATCACCAC
AGTTCTTAAAGACGACCTTTGCTAACTATGAGTTGATTGCTTCTGAAAATGATCGTATTTTTGAGTATGAAAATCGGATT
TATCGTCCCTTCATGACCGATCAGTTGCTCCTAAAACAGCTCATGACCATTTTATTTGACAATGCCATCAAGTATACCGA
AGAAGATGGGAAAATTGAGTTCGTAGTTCATGCTACAGATCGTCACCTCTATCTAACAGTAACGGATAACGGAATTGGAA
TCTCAGCTGCTGATAAGAAGAAAATCTTTGACCGTTTTTACCGTGTAGACAAGGCAAGAACTCGTCAGAAAGGTGGCTTT
GGTCTTGGACTATCTTTAGCCAAGCAGATCGTAGATGCCTTACGAGGAACGATTAGCGTCAAAGATAACAAACCTAGAGG
AACAATTTTTGAAGTTAAAATCGCTATTCAATCTCCTTCAAAACGTAAGAATAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)

His Kinase A (phospho-acceptor) domain (HisKA)

(218-283)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5B7Y5I8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

83.747

99.551

0.834
  ciaH Streptococcus pneumoniae D39

83.747

99.551

0.834
  ciaH Streptococcus pneumoniae R6

83.747

99.551

0.834
  ciaH Streptococcus pneumoniae TIGR4

83.747

99.551

0.834
  ciaH Streptococcus mutans UA159

55.023

98.427

0.542

Multiple sequence alignment