Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   GO004_RS14405 Genome accession   NZ_CP046591
Coordinates   2745688..2746890 (+) Length   400 a.a.
NCBI ID   WP_015250812.1    Uniprot ID   A0ABU0V6N7
Organism   Bacillus subtilis strain R31     
Function   require for competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2740688..2751890
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GO004_RS14385 (GO004_14375) walK 2740769..2742604 (+) 1836 WP_009968432.1 cell wall metabolism sensor histidine kinase WalK -
  GO004_RS14390 (GO004_14380) walH 2742594..2743961 (+) 1368 WP_046664054.1 WalRK two-component regulatory system regulator WalH -
  GO004_RS14395 (GO004_14385) walI 2743948..2744790 (+) 843 WP_128422530.1 WalRK two-component regulatory system regulator WalI -
  GO004_RS14400 (GO004_14390) vicX 2744812..2745606 (+) 795 WP_088467475.1 MBL fold metallo-hydrolase Regulator
  GO004_RS14405 (GO004_14395) htrA 2745688..2746890 (+) 1203 WP_015250812.1 serine protease HtrC Regulator
  GO004_RS14410 (GO004_14400) - 2746911..2747040 (+) 130 Protein_2810 hypothetical protein -
  GO004_RS14415 (GO004_14405) - 2747068..2747220 (+) 153 Protein_2811 ATP-binding protein -
  GO004_RS14420 (GO004_14410) rocR 2747202..2748587 (-) 1386 WP_003244510.1 arginine utilization regulatory protein RocR -
  GO004_RS14425 (GO004_14415) - 2748818..2749102 (+) 285 WP_015715052.1 autorepressor SdpR family transcription factor -
  GO004_RS14430 (GO004_14420) - 2749102..2749737 (+) 636 WP_041520538.1 SdpI family protein -
  GO004_RS14435 (GO004_14425) - 2749921..2750475 (+) 555 WP_015715050.1 SdpA family antimicrobial peptide system protein -
  GO004_RS14440 (GO004_14430) - 2750460..2751413 (+) 954 WP_015715049.1 sporulation-delaying protein SdpB family protein -

Sequence

Protein


Download         Length: 400 a.a.        Molecular weight: 42756.50 Da        Isoelectric Point: 5.5340

>NTDB_id=353631 GO004_RS14405 WP_015250812.1 2745688..2746890(+) (htrA) [Bacillus subtilis strain R31]
MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPYLSNEGLDTGALDQQQNNNGRESIRTVNVSVNNTVTK
IVSNVSPAVVGVVNIQKSDIRGESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL
AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVDSNGDGQPDWNAEVLQTDAAINP
GNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPSKLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPK
NVTNGAVVMGVDAFSPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKLSSADQLGS

Nucleotide


Download         Length: 1203 bp        

>NTDB_id=353631 GO004_RS14405 WP_015250812.1 2745688..2746890(+) (htrA) [Bacillus subtilis strain R31]
ATGGTGGATTACGAACGTGAGGAAGAACATACTACTCCTGAACAGCCAAAGAGAAGCAAAAAAGGATATTTTCTTTCGAG
TCTGATTGGTGTGATTGTCGGTGCCGTATTAATGGCGTTTATCATGCCGTACCTTTCAAATGAAGGGCTAGATACAGGCG
CCTTAGATCAGCAGCAGAACAATAACGGACGGGAATCAATCAGGACGGTGAATGTCAGTGTCAACAATACGGTCACCAAG
ATTGTCAGCAATGTGTCGCCCGCCGTTGTCGGTGTTGTGAACATCCAAAAATCAGATATACGGGGAGAGAGCGGGGAGGC
TGGGAGCGGCTCTGGCGTCATCTATAAGAAAAATGACCATTCCGCTTATGTCGTGACCAACCATCATGTCATCGAAGGCG
CTTCCCAAATTGAAATCAGCTTGAAAGACGGCTCGCGTGTATCAGCTGATCTTGTCGGCAGCGACCAGCTGATGGATCTG
GCCGTTTTACGGGTGAAAAGCGATAAAATTAAAGCAGTCGCCGATTTCGGAAATTCAGATAAAGTGAAGTCTGGGGAGCC
GGTTATTGCGATCGGGAACCCGTTAGGCCTTGAGTTTGCTGGCTCTGTCACACAAGGCGTCATCTCGGGTACGGAGAGGG
CGATCCCAGTAGATTCAAACGGTGATGGACAGCCTGACTGGAACGCAGAAGTCCTGCAAACAGATGCGGCCATTAACCCT
GGGAACAGCGGCGGTGCTTTGTTAAATATGGATGGGAAGGTCATTGGCATCAATTCAATGAAAATTGCCGAGTCAGCGGT
TGAAGGGATTGGCCTGTCCATTCCGTCTAAGCTCGTGATCCCTGTGATAGAGGATTTAGAGAGATACGGAAAGGTCAAAC
GCCCGTTCCTTGGCATTGAGATGAAATCCCTAAGCGACATCGCAAGCTATCATTGGGATGAAACATTAAAGCTTCCTAAG
AACGTCACCAATGGAGCGGTTGTGATGGGTGTAGACGCCTTTTCACCTGCCGGAAAAGCGGGACTGAAGGAACTCGATGT
CATCACGGAATTTGACGGTTACAAAGTAAATGATATTGTTGACCTGCGAAAACGGCTTTATCAGAAAAAAGTCGGTGACC
GGGTGAAGGTGAAGTTTTACCGCGGCGGAAAAGAAAAATCTGTTGACATCAAGCTGTCGTCCGCAGACCAATTAGGAAGT
TAA

Domains

Predicted by InterProScan.

PDZ domain (PDZ_2)

(295-392)

Peptidase family M50 (Peptidase_M50)

(196-395)

Trypsin-like peptidase domain (Trypsin_2)

(110-257)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

43.829

99.25

0.435
  htrA Streptococcus gordonii str. Challis substr. CH1

41.791

100

0.42
  htrA Streptococcus mitis NCTC 12261

43.005

96.5

0.415
  htrA Streptococcus pneumoniae TIGR4

45.758

82.5

0.378
  htrA Streptococcus pneumoniae D39

45.758

82.5

0.378
  htrA Streptococcus pneumoniae Rx1

45.758

82.5

0.378
  htrA Streptococcus pneumoniae R6

45.758

82.5

0.378

Multiple sequence alignment