Detailed information NTG0352667

Bioinformatically predicted

Overview

• Name: comC/comC2
• Type: Regulator
• Locus tag: ES276_RS10760
• Genome accession: NZ_CP038252
• Coordinates: 2136568..2136693 (-)
• Length: 41 a.a.
• NCBI ID: WP_000799686.1
• Uniprot ID: P60242
• Organism: Streptococcus pneumoniae strain TVO_1901936
• Function: binding to ComD; induce autophosphorylation of ComD (predicted from homology) Competence regulation

Genomic Context

Location: 2131568..2141693

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ES276_RS10730 (ES276_11405)	-	2132442..2132984 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
ES276_RS10745 (ES276_11420)	-	2133531..2134484 (+)	954	WP_001155321.1	IS30-like element ISSpn8 family transposase	-
ES276_RS10750 (ES276_11425)	comE	2134487..2135224 (-)	738	WP_000866067.1	competence system response regulator transcription factor ComE	Regulator
ES276_RS10755 (ES276_11430)	comD	2135221..2136547 (-)	1327	Protein_2108	competence system sensor histidine kinase ComD	-
ES276_RS10760 (ES276_11435)	comC/comC2	2136568..2136693 (-)	126	WP_000799686.1	competence-stimulating peptide ComC	Regulator
ES276_RS10770 (ES276_11445)	rlmH	2136975..2137454 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ES276_RS10775 (ES276_11450)	htrA	2137637..2138818 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
ES276_RS10780 (ES276_11455)	spo0J	2138876..2139634 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 41 a.a.
• Molecular weight: 4907.00 Da
• Isoelectric Point: 11.0006

>NTDB_id=352667 ES276_RS10760 WP_000799686.1 2136568..2136693(-) (comC/comC2) [Streptococcus pneumoniae strain TVO_1901936]
MKNTVKLEQFVALKEKDLQKIKGGEMRISRIILDFLFLRKK

Nucleotide

• Length: 126 bp

>NTDB_id=352667 ES276_RS10760 WP_000799686.1 2136568..2136693(-) (comC/comC2) [Streptococcus pneumoniae strain TVO_1901936]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAAGATTAAAGGTGGGGAGATGAG
GATTTCAAGAATCATCCTTGATTTTCTTTTCCTACGAAAAAAGTAA

Domains

Predicted by InterproScan.

• COMC family (ComC) (1-29)

3D structure

• PDB: 6CJ8
• PDB: 6COO
• PDB: 6COP
• PDB: 6COQ
• PDB: 6COR
• PDB: 6COS
• PDB: 6COW
• PDB: 6OBW
• PDB: 6OC2
• PDB: 6OC4
• PDB: 6OLD
• PDB: 6V1N

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comC/comC2	Streptococcus pneumoniae A66	100	100	1
comC/comC2	Streptococcus pneumoniae TIGR4	100	100	1
comC/comC1	Streptococcus pneumoniae R6	80.488	100	0.805
comC/comC1	Streptococcus pneumoniae G54	80.488	100	0.805
comC/comC1	Streptococcus pneumoniae D39	80.488	100	0.805
comC/comC1	Streptococcus pneumoniae Rx1	80.488	100	0.805
comC	Streptococcus mitis SK321	75.61	100	0.756
comC	Streptococcus mitis NCTC 12261	57.5	97.561	0.561