Detailed information NTG0352668

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: ES276_RS10775
• Genome accession: NZ_CP038252
• Coordinates: 2137637..2138818 (+)
• Length: 393 a.a.
• NCBI ID: WP_000681597.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain TVO_1901936
• Function: degrading CSP; selective degradation of ComEA and ComEC (predicted from homology) Competence regulation

Genomic Context

Location: 2132637..2143818

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ES276_RS10745 (ES276_11420)	-	2133531..2134484 (+)	954	WP_001155321.1	IS30-like element ISSpn8 family transposase	-
ES276_RS10750 (ES276_11425)	comE	2134487..2135224 (-)	738	WP_000866067.1	competence system response regulator transcription factor ComE	Regulator
ES276_RS10755 (ES276_11430)	comD	2135221..2136547 (-)	1327	Protein_2108	competence system sensor histidine kinase ComD	-
ES276_RS10760 (ES276_11435)	comC/comC2	2136568..2136693 (-)	126	WP_000799686.1	competence-stimulating peptide ComC	Regulator
ES276_RS10770 (ES276_11445)	rlmH	2136975..2137454 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ES276_RS10775 (ES276_11450)	htrA	2137637..2138818 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
ES276_RS10780 (ES276_11455)	spo0J	2138876..2139634 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41841.72 Da
• Isoelectric Point: 6.8902

>NTDB_id=352668 ES276_RS10775 WP_000681597.1 2137637..2138818(+) (htrA) [Streptococcus pneumoniae strain TVO_1901936]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVI
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=352668 ES276_RS10775 WP_000681597.1 2137637..2138818(+) (htrA) [Streptococcus pneumoniae strain TVO_1901936]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATTAATGGCGCCAGCAAAGTAGATATTCGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAAATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAATT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

• PDZ domain (PDZ_2) (289-384)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus pneumoniae Rx1	100	100	1
htrA	Streptococcus pneumoniae D39	100	100	1
htrA	Streptococcus pneumoniae R6	100	100	1
htrA	Streptococcus pneumoniae TIGR4	100	100	1
htrA	Streptococcus mitis NCTC 12261	97.201	100	0.972
htrA	Streptococcus gordonii str. Challis substr. CH1	66.414	100	0.669
htrA	Streptococcus mutans UA159	54.569	100	0.547