Detailed information NTG0351418

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: E3C75_RS07395
• Genome accession: NZ_CP038020
• Coordinates: 1397009..1397848 (+)
• Length: 279 a.a.
• NCBI ID: WP_011225887.1
• Uniprot ID: Q5M4N4
• Organism: Streptococcus thermophilus strain ATCC 19258
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 1392009..1402848

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E3C75_RS07365	-	1392425..1392952 (+)	528	WP_041827017.1	ECF transporter S component	-
E3C75_RS07370	-	1392976..1393491 (+)	516	WP_011225884.1	transcription repressor NadR	-
E3C75_RS07375	-	1393586..1394275 (+)	690	WP_046206437.1	helix-turn-helix transcriptional regulator	-
E3C75_RS07380	ylqF	1394403..1395257 (+)	855	WP_084828773.1	ribosome biogenesis GTPase YlqF	-
E3C75_RS07385	-	1395244..1396011 (+)	768	WP_084825950.1	ribonuclease HII	-
E3C75_RS12140	-	1396022..1396941 (+)	920	Protein_1421	ROK family protein	-
E3C75_RS07395	dprA	1397009..1397848 (+)	840	WP_011225887.1	DNA-processing protein DprA	Machinery gene
E3C75_RS07400	topA	1398016..1400154 (+)	2139	WP_084825951.1	type I DNA topoisomerase	-
E3C75_RS07405	-	1400271..1401095 (+)	825	WP_011681087.1	TraX family protein	-
E3C75_RS07410	-	1401131..1401790 (+)	660	WP_084825952.1	response regulator transcription factor	-

Sequence

Protein

• Length: 279 a.a.
• Molecular weight: 31247.18 Da
• Isoelectric Point: 8.6571

>NTDB_id=351418 E3C75_RS07395 WP_011225887.1 1397009..1397848(+) (dprA) [Streptococcus thermophilus strain ATCC 19258]
MNNFELFKLKAAGLTNLNILNILDYQKNQDKKLSLRDMAVVSKSKNAVLFMEKYKNLDVKQLKEDFQRFPTLSIFDKEYP
IELKHSYNPPVLLFYQGNIDLLSKPKLAVVGARKCSETGKQSVRKIVHELGNAFTIVSGLARGIDTCAHMEALKNKGNTI
AVIGTGLDVYYPKENKALQDYMAKNHLVLTEYGPGEQPLKYHYPERNRIISGLCQGVMVVEAKLRSGSLITCERAMEEGR
DVFAIPGNILDGKSDGCHHLIQEGAKCITTGFDIISEFS

Nucleotide

• Length: 840 bp

>NTDB_id=351418 E3C75_RS07395 WP_011225887.1 1397009..1397848(+) (dprA) [Streptococcus thermophilus strain ATCC 19258]
ATGAATAACTTTGAACTTTTTAAACTAAAAGCTGCTGGATTGACGAATTTAAACATCCTTAACATTTTAGACTATCAAAA
AAATCAAGATAAAAAATTGAGCTTACGTGATATGGCAGTGGTATCTAAGTCTAAAAATGCCGTTCTCTTTATGGAAAAAT
ACAAGAATTTGGATGTTAAGCAGCTTAAGGAAGATTTTCAACGTTTTCCGACCTTATCAATTTTTGATAAGGAGTATCCC
ATTGAGCTGAAACATTCCTATAATCCTCCTGTTCTCCTCTTTTATCAAGGGAATATTGATTTGCTAAGTAAACCCAAGTT
AGCAGTAGTTGGTGCCAGAAAGTGTTCTGAAACAGGCAAACAGTCTGTTCGAAAAATTGTTCATGAACTTGGGAATGCCT
TTACTATTGTAAGTGGCTTGGCGCGTGGAATTGATACTTGTGCTCATATGGAGGCCTTAAAAAATAAAGGTAACACCATT
GCAGTTATCGGGACTGGGCTAGACGTATATTATCCTAAAGAAAACAAAGCTTTACAGGACTATATGGCTAAAAATCATTT
AGTTCTTACAGAATACGGACCGGGTGAACAGCCACTTAAATACCATTATCCTGAACGAAATCGGATAATTTCTGGATTGT
GTCAAGGGGTTATGGTGGTTGAAGCCAAGCTTCGCTCGGGAAGTCTTATTACTTGTGAGCGTGCAATGGAAGAAGGAAGA
GATGTTTTCGCCATACCAGGAAATATTTTAGATGGAAAATCGGATGGATGCCATCACCTCATTCAAGAGGGCGCAAAGTG
CATTACTACAGGATTTGACATCATTTCAGAATTTTCATAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (71-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: Q5M4N4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	72.043	100	0.72
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	63.309	99.642	0.631
dprA/cilB/dalA	Streptococcus pneumoniae D39	63.309	99.642	0.631
dprA/cilB/dalA	Streptococcus pneumoniae R6	63.309	99.642	0.631
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	63.309	99.642	0.631
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	62.95	99.642	0.627
dprA/cilB/dalA	Streptococcus mitis SK321	62.95	99.642	0.627
dprA	Lactococcus lactis subsp. cremoris KW2	60.432	99.642	0.602
dprA	Latilactobacillus sakei subsp. sakei 23K	39.768	92.832	0.369
dprA	Bacillus subtilis subsp. subtilis str. 168	48.095	75.269	0.362