Detailed information NTG0351061

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: GL185_RS11595
• Genome accession: NZ_CP046357
• Coordinates: 1011956..1012543 (+)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain 525
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1006956..1017543

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GL185_RS05005 (GL185_05055)	-	1007216..1007905 (-)	690	WP_000760532.1	CPBP family intramembrane glutamic endopeptidase	-
GL185_RS05010 (GL185_05060)	-	1007957..1008340 (-)	384	WP_000877381.1	hypothetical protein	-
GL185_RS05015 (GL185_05065)	-	1008969..1009288 (-)	320	Protein_1005	immunity protein	-
GL185_RS05020 (GL185_05075)	-	1009808..1009927 (-)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
GL185_RS05025 (GL185_05080)	cipB	1010031..1010180 (-)	150	WP_001809846.1	bacteriocin-like peptide BlpO	Regulator
GL185_RS05030 (GL185_05085)	blpK	1010424..1010672 (-)	249	WP_000379965.1	bacteriocin-like peptide BlpK	-
GL185_RS05035 (GL185_05090)	blpJ	1010741..1011010 (-)	270	WP_001093248.1	bacteriocin-like peptide BlpJ	-
GL185_RS05040 (GL185_05095)	blpI	1011477..1011674 (-)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
GL185_RS11595	comA/nlmT	1011956..1012543 (+)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
GL185_RS05050 (GL185_05100)	comA/nlmT	1012470..1014113 (+)	1644	WP_078133412.1	peptide cleavage/export ABC transporter	Regulator
GL185_RS05055 (GL185_05105)	-	1014124..1015485 (+)	1362	WP_001069060.1	bacteriocin secretion accessory protein	-
GL185_RS05060 (GL185_05110)	blpC	1015542..1015670 (+)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
GL185_RS05065 (GL185_05115)	-	1015852..1016181 (+)	330	WP_000132572.1	hypothetical protein	-
GL185_RS05070 (GL185_05120)	pptB	1016349..1017398 (-)	1050	WP_000653771.1	ABC transporter permease	Regulator

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=351061 GL185_RS11595 WP_000205166.1 1011956..1012543(+) (comA/nlmT) [Streptococcus pneumoniae strain 525]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=351061 GL185_RS11595 WP_000205166.1 1011956..1012543(+) (comA/nlmT) [Streptococcus pneumoniae strain 525]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterProScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497