Detailed information NTG0342159

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: ETT50_RS00335
• Genome accession: NZ_CP035449
• Coordinates: 52882..53793 (+)
• Length: 303 a.a.
• NCBI ID: WP_032464762.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm56
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 47882..58793

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT50_RS00315 (ETT50_00315)	purE	48468..48959 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
ETT50_RS00320 (ETT50_00320)	purK	48946..50019 (+)	1074	WP_032464761.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
ETT50_RS00325 (ETT50_00325)	-	50021..51439 (+)	1419	WP_011888524.1	hypothetical protein	-
ETT50_RS00330 (ETT50_00330)	purB	51459..52751 (+)	1293	WP_030126529.1	adenylosuccinate lyase	-
ETT50_RS00335 (ETT50_00335)	comR	52882..53793 (+)	912	WP_032464762.1	XRE family transcriptional regulator	Regulator
ETT50_RS09480	comS	53884..53982 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
ETT50_RS00340 (ETT50_00340)	ruvB	54013..55011 (+)	999	WP_014407198.1	Holliday junction branch migration DNA helicase RuvB	-
ETT50_RS00345 (ETT50_00345)	-	55149..55586 (+)	438	WP_014635221.1	low molecular weight protein-tyrosine-phosphatase	-
ETT50_RS00350 (ETT50_00350)	-	55609..56010 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
ETT50_RS00355 (ETT50_00355)	-	56007..57782 (+)	1776	WP_032464763.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35915.55 Da
• Isoelectric Point: 4.9349

>NTDB_id=342159 ETT50_RS00335 WP_032464762.1 52882..53793(+) (comR) [Streptococcus pyogenes strain emm56]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELR
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDAQFYEEITESMLKQHNNLSLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=342159 ETT50_RS00335 WP_032464762.1 52882..53793(+) (comR) [Streptococcus pyogenes strain emm56]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAGA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGCACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTATCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.01	100	0.99
comR	Streptococcus pyogenes MGAS8232	58.14	99.34	0.578
comR	Streptococcus mutans UA159	46.823	98.68	0.462
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.102	97.36	0.449
comR	Streptococcus suis P1/7	37.037	98.02	0.363
comR	Streptococcus suis 05ZYH33	37.037	98.02	0.363