Detailed information NTG0341140

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: ETT69_RS00335
• Genome accession: NZ_CP035430
• Coordinates: 53898..54809 (+)
• Length: 303 a.a.
• NCBI ID: WP_136019555.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm55
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48898..59809

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT69_RS00315 (ETT69_00315)	purE	49182..49673 (+)	492	WP_136019559.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
ETT69_RS00320 (ETT69_00320)	purK	49660..50733 (+)	1074	WP_168389141.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
ETT69_RS00325 (ETT69_00325)	-	50760..52457 (+)	1698	WP_136019557.1	AIPR family protein	-
ETT69_RS00330 (ETT69_00330)	purB	52475..53767 (+)	1293	WP_136019556.1	adenylosuccinate lyase	-
ETT69_RS00335 (ETT69_00335)	comR	53898..54809 (+)	912	WP_136019555.1	XRE family transcriptional regulator	Regulator
ETT69_RS09805	comS	54900..54998 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
ETT69_RS00340 (ETT69_00340)	ruvB	55029..56027 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
ETT69_RS00345 (ETT69_00345)	-	56165..56602 (+)	438	WP_136019554.1	low molecular weight protein-tyrosine-phosphatase	-
ETT69_RS00350 (ETT69_00350)	-	56625..57026 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
ETT69_RS00355 (ETT69_00355)	-	57023..58798 (+)	1776	WP_136019553.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35915.55 Da
• Isoelectric Point: 4.9349

>NTDB_id=341140 ETT69_RS00335 WP_136019555.1 53898..54809(+) (comR) [Streptococcus pyogenes strain emm55]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRRSIYNLNE
LLLIDLYLIILVVSHFSDDIFDAQFYEEITESMLKQHNNLSLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=341140 ETT69_RS00335 WP_136019555.1 53898..54809(+) (comR) [Streptococcus pyogenes strain emm55]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTCTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAGATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGCACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTATCATTGGAGGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (73-296)

• Helix-turn-helix (HTH_3) (12-64)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.01	100	0.99
comR	Streptococcus pyogenes MGAS8232	58.14	99.34	0.578
comR	Streptococcus mutans UA159	46.823	98.68	0.462
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.102	97.36	0.449
comR	Streptococcus suis P1/7	37.037	98.02	0.363
comR	Streptococcus suis 05ZYH33	37.037	98.02	0.363