Detailed information
Bioinformatically predicted
Overview
| Name | dprA | Type | Machinery gene |
| Locus tag | ETT71_RS04840 | Genome accession | NZ_CP035428 |
| Coordinates | 927673..928509 (+) | Length | 278 a.a. |
| NCBI ID | WP_136093383.1 | Uniprot ID | - |
| Organism | Streptococcus pyogenes strain emmSTG866.1 | ||
| Function | ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 912427..982207 | 927673..928509 | within | 0 |
Gene organization within MGE regions
Location: 912427..982207
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ETT71_RS04775 (ETT71_04770) | - | 913993..915720 (+) | 1728 | WP_032465017.1 | ABC transporter ATP-binding protein | - |
| ETT71_RS04780 (ETT71_04775) | nox | 915961..917331 (+) | 1371 | WP_011184515.1 | H2O-forming NADH oxidase | - |
| ETT71_RS04785 (ETT71_04780) | - | 917490..918473 (-) | 984 | WP_002984645.1 | L-lactate dehydrogenase | - |
| ETT71_RS04790 (ETT71_04785) | gyrA | 918664..921150 (+) | 2487 | WP_031488280.1 | DNA gyrase subunit A | - |
| ETT71_RS04795 (ETT71_04790) | - | 921170..921919 (+) | 750 | WP_002984641.1 | class A sortase | - |
| ETT71_RS04800 (ETT71_04795) | - | 922002..922415 (+) | 414 | WP_136093411.1 | VOC family protein | - |
| ETT71_RS09510 (ETT71_04805) | - | 923029..923595 (+) | 567 | WP_136288996.1 | hypothetical protein | - |
| ETT71_RS04815 (ETT71_04810) | - | 923645..924556 (-) | 912 | WP_002989777.1 | diacylglycerol kinase family protein | - |
| ETT71_RS04820 (ETT71_04815) | - | 924673..925323 (-) | 651 | WP_002984629.1 | hemolysin III family protein | - |
| ETT71_RS04825 (ETT71_04820) | - | 925320..925760 (-) | 441 | WP_002989774.1 | DUF1836 domain-containing protein | - |
| ETT71_RS04830 (ETT71_04825) | ylqF | 925979..926827 (+) | 849 | WP_136093381.1 | ribosome biogenesis GTPase YlqF | - |
| ETT71_RS04835 (ETT71_04830) | - | 926817..927608 (+) | 792 | WP_136093382.1 | ribonuclease HII | - |
| ETT71_RS04840 (ETT71_04835) | dprA | 927673..928509 (+) | 837 | WP_136093383.1 | DNA-processing protein DprA | Machinery gene |
| ETT71_RS04845 (ETT71_04840) | topA | 928617..930746 (+) | 2130 | WP_011017773.1 | type I DNA topoisomerase | - |
| ETT71_RS09200 | - | 930821..931705 (-) | 885 | Protein_891 | LysR family transcriptional regulator | - |
| ETT71_RS04860 (ETT71_04855) | - | 931718..932284 (+) | 567 | Protein_892 | PTS sugar transporter subunit IIC | - |
| ETT71_RS04865 (ETT71_04860) | - | 932299..933291 (+) | 993 | WP_136093384.1 | D-lactate dehydrogenase | - |
| ETT71_RS04870 (ETT71_04865) | - | 933396..934061 (+) | 666 | WP_136093385.1 | SatD family protein | - |
| ETT71_RS04875 (ETT71_04870) | - | 934054..934770 (+) | 717 | WP_136093386.1 | DUF3307 domain-containing protein | - |
| ETT71_RS04880 (ETT71_04875) | trmFO | 934921..936267 (+) | 1347 | WP_014407588.1 | methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO | - |
| ETT71_RS04885 (ETT71_04880) | - | 936424..937827 (+) | 1404 | WP_281727103.1 | pyruvate carboxylase subunit B | - |
| ETT71_RS04890 (ETT71_04885) | - | 937870..938184 (+) | 315 | WP_136093388.1 | hypothetical protein | - |
| ETT71_RS04895 (ETT71_04890) | - | 938184..938534 (+) | 351 | WP_009881174.1 | biotin/lipoyl-containing protein | - |
| ETT71_RS04900 (ETT71_04895) | - | 938544..939674 (+) | 1131 | WP_136093389.1 | sodium ion-translocating decarboxylase subunit beta | - |
| ETT71_RS04905 (ETT71_04900) | citG | 939875..940759 (-) | 885 | WP_011054506.1 | triphosphoribosyl-dephospho-CoA synthase CitG | - |
| ETT71_RS04910 (ETT71_04905) | - | 940752..941447 (-) | 696 | WP_002995032.1 | GntR family transcriptional regulator | - |
| ETT71_RS04915 (ETT71_04910) | - | 941605..943008 (-) | 1404 | WP_014635470.1 | CitMHS family transporter | - |
| ETT71_RS04920 (ETT71_04915) | - | 943389..943712 (+) | 324 | WP_011017780.1 | hypothetical protein | - |
| ETT71_RS04925 (ETT71_04920) | - | 943769..944164 (+) | 396 | WP_020833483.1 | acetyl-CoA carboxylase biotin carboxyl carrier protein subunit | - |
| ETT71_RS04930 (ETT71_04925) | - | 944209..945330 (+) | 1122 | WP_002991766.1 | sodium ion-translocating decarboxylase subunit beta | - |
| ETT71_RS09370 | - | 945348..945482 (+) | 135 | WP_003050685.1 | OadG-related small transporter subunit | - |
| ETT71_RS04935 (ETT71_04930) | citD | 945518..945826 (+) | 309 | WP_002991770.1 | citrate lyase acyl carrier protein | - |
| ETT71_RS04940 (ETT71_04935) | citE | 945814..946701 (+) | 888 | WP_003056097.1 | citrate (pro-3S)-lyase subunit beta | - |
| ETT71_RS04945 (ETT71_04940) | citF | 946704..948236 (+) | 1533 | WP_111694817.1 | citrate lyase subunit alpha | - |
| ETT71_RS04950 (ETT71_04945) | citX | 948229..948807 (+) | 579 | WP_010922331.1 | citrate lyase holo-[acyl-carrier protein] synthase | - |
| ETT71_RS04955 (ETT71_04950) | - | 948822..950216 (+) | 1395 | WP_023612467.1 | oxaloacetate decarboxylase subunit alpha | - |
| ETT71_RS04960 (ETT71_04955) | citC | 950326..951378 (-) | 1053 | WP_136093390.1 | [citrate (pro-3S)-lyase] ligase | - |
| ETT71_RS04965 (ETT71_04960) | - | 951467..951949 (-) | 483 | WP_136093391.1 | PASTA domain-containing protein | - |
| ETT71_RS04970 (ETT71_04965) | xerS | 952649..953719 (-) | 1071 | WP_002984598.1 | tyrosine recombinase XerS | - |
| ETT71_RS04975 (ETT71_04970) | - | 954194..954892 (+) | 699 | WP_002993300.1 | S24 family peptidase | - |
| ETT71_RS04980 (ETT71_04975) | ffh | 955027..956589 (-) | 1563 | WP_002993302.1 | signal recognition particle protein | - |
| ETT71_RS04985 (ETT71_04980) | - | 956604..956936 (-) | 333 | WP_002989745.1 | putative DNA-binding protein | - |
| ETT71_RS04990 (ETT71_04985) | - | 957034..957732 (-) | 699 | WP_002989743.1 | GntR family transcriptional regulator | - |
| ETT71_RS04995 (ETT71_04990) | - | 957815..959248 (-) | 1434 | WP_136083510.1 | hypothetical protein | - |
| ETT71_RS05000 (ETT71_04995) | guaA | 959415..960977 (+) | 1563 | WP_136018664.1 | glutamine-hydrolyzing GMP synthase | - |
| ETT71_RS05005 (ETT71_05000) | - | 961045..962238 (-) | 1194 | WP_000237797.1 | site-specific integrase | - |
| ETT71_RS05010 (ETT71_05005) | - | 962265..962465 (-) | 201 | WP_000633907.1 | DUF3173 family protein | - |
| ETT71_RS05020 (ETT71_05015) | - | 962963..963193 (-) | 231 | WP_000845143.1 | helix-turn-helix domain-containing protein | - |
| ETT71_RS05025 (ETT71_05020) | - | 963190..963612 (-) | 423 | WP_000804879.1 | RNA polymerase sigma factor | - |
| ETT71_RS05035 (ETT71_05030) | - | 964143..964496 (+) | 354 | WP_001227350.1 | helix-turn-helix domain-containing protein | - |
| ETT71_RS05040 (ETT71_05035) | - | 964554..964742 (-) | 189 | WP_032506803.1 | cysteine-rich KTR domain-containing protein | - |
| ETT71_RS05045 (ETT71_05040) | tet(M) | 964840..966759 (-) | 1920 | WP_000691737.1 | tetracycline resistance ribosomal protection protein Tet(M) | - |
| ETT71_RS09515 | - | 966775..966822 (-) | 48 | Protein_929 | hypothetical protein | - |
| ETT71_RS05060 (ETT71_05055) | - | 967136..968065 (-) | 930 | WP_000584386.1 | conjugal transfer protein | - |
| ETT71_RS05065 (ETT71_05060) | - | 968082..969104 (-) | 1023 | WP_000768372.1 | bifunctional lytic transglycosylase/C40 family peptidase | - |
| ETT71_RS05070 (ETT71_05065) | - | 969101..971128 (-) | 2028 | WP_000192392.1 | CD3337/EF1877 family mobilome membrane protein | - |
| ETT71_RS05075 (ETT71_05070) | - | 971125..973578 (-) | 2454 | WP_000331165.1 | ATP-binding protein | - |
| ETT71_RS05080 (ETT71_05075) | - | 973562..973957 (-) | 396 | WP_000723887.1 | conjugal transfer protein | - |
| ETT71_RS05085 (ETT71_05080) | - | 974029..974667 (-) | 639 | WP_000248477.1 | DUF6037 family protein | - |
| ETT71_RS05090 (ETT71_05085) | - | 974723..975223 (-) | 501 | WP_000425404.1 | antirestriction protein ArdA | - |
| ETT71_RS05095 (ETT71_05090) | - | 975284..976063 (-) | 780 | WP_000675717.1 | abortive infection family protein | - |
| ETT71_RS05100 (ETT71_05095) | - | 976105..976326 (-) | 222 | WP_001009054.1 | hypothetical protein | - |
| ETT71_RS05105 (ETT71_05100) | - | 976323..976613 (-) | 291 | WP_000055376.1 | hypothetical protein | - |
| ETT71_RS05110 (ETT71_05105) | mobT | 976610..977794 (-) | 1185 | WP_000426689.1 | MobT family relaxase | - |
| ETT71_RS05115 (ETT71_05110) | - | 977976..979379 (-) | 1404 | WP_001130244.1 | FtsK/SpoIIIE domain-containing protein | - |
| ETT71_RS05120 (ETT71_05115) | - | 979401..980174 (-) | 774 | WP_000185761.1 | hypothetical protein | - |
| ETT71_RS05125 (ETT71_05120) | - | 980184..980561 (-) | 378 | WP_001234191.1 | YdcP family protein | - |
| ETT71_RS05130 (ETT71_05125) | - | 980582..980896 (-) | 315 | WP_000421279.1 | YdcP family protein | - |
Sequence
Protein
Download Length: 278 a.a. Molecular weight: 31022.96 Da Isoelectric Point: 8.8230
>NTDB_id=341062 ETT71_RS04840 WP_136093383.1 927673..928509(+) (dprA) [Streptococcus pyogenes strain emmSTG866.1]
MNHFELYKLKKAGLTNKNILNILDYQEHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVFLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPGEEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGATCVTSGMDILSEY
MNHFELYKLKKAGLTNKNILNILDYQEHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVFLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPGEEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGATCVTSGMDILSEY
Nucleotide
Download Length: 837 bp
>NTDB_id=341062 ETT71_RS04840 WP_136093383.1 927673..928509(+) (dprA) [Streptococcus pyogenes strain emmSTG866.1]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCCGTTGTTTCCGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCTTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTCGGCTCCAGACGCTCAAGCGATACTGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAATCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACTATC
GCTATTATTGGAACAGGATTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAGGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAACATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCCGTTGTTTCCGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCTTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTCGGCTCCAGACGCTCAAGCGATACTGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAATCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACTATC
GCTATTATTGGAACAGGATTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAGGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAACATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| dprA | Streptococcus mutans UA159 |
67.266 |
100 |
0.673 |
| dprA/cilB/dalA | Streptococcus pneumoniae Rx1 |
60.432 |
100 |
0.604 |
| dprA/cilB/dalA | Streptococcus pneumoniae D39 |
60.432 |
100 |
0.604 |
| dprA/cilB/dalA | Streptococcus pneumoniae R6 |
60.432 |
100 |
0.604 |
| dprA/cilB/dalA | Streptococcus pneumoniae TIGR4 |
60.432 |
100 |
0.604 |
| dprA/cilB/dalA | Streptococcus mitis SK321 |
60.432 |
100 |
0.604 |
| dprA/cilB/dalA | Streptococcus mitis NCTC 12261 |
60.072 |
100 |
0.601 |
| dprA | Lactococcus lactis subsp. cremoris KW2 |
57.194 |
100 |
0.572 |
| dprA | Legionella pneumophila strain ERS1305867 |
42.857 |
85.612 |
0.367 |