Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicR   Type   Regulator
Locus tag   ETT73_RS02370 Genome accession   NZ_CP035426
Coordinates   425238..425948 (+) Length   236 a.a.
NCBI ID   WP_002985645.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm57     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 420238..430948
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT73_RS02345 (ETT73_02340) - 420247..420960 (+) 714 WP_302622836.1 MIP/aquaporin family protein -
  ETT73_RS02350 (ETT73_02345) - 421095..421664 (+) 570 WP_136020185.1 hypothetical protein -
  ETT73_RS02355 (ETT73_02350) - 421633..422781 (+) 1149 WP_136112721.1 acetyl-CoA C-acyltransferase -
  ETT73_RS02360 (ETT73_02355) - 422738..423985 (+) 1248 WP_136112722.1 AMP-binding protein -
  ETT73_RS02365 (ETT73_02360) - 424081..425076 (+) 996 WP_136099116.1 DUF3114 domain-containing protein -
  ETT73_RS02370 (ETT73_02365) vicR 425238..425948 (+) 711 WP_002985645.1 response regulator YycF Regulator
  ETT73_RS02375 (ETT73_02370) vicK 425941..427293 (+) 1353 WP_002995609.1 cell wall metabolism sensor histidine kinase VicK Regulator
  ETT73_RS02380 (ETT73_02375) vicX 427297..428106 (+) 810 WP_002985641.1 MBL fold metallo-hydrolase Regulator
  ETT73_RS02385 (ETT73_02380) rnc 428538..429230 (+) 693 WP_002990670.1 ribonuclease III -

Sequence

Protein


Download         Length: 236 a.a.        Molecular weight: 27083.99 Da        Isoelectric Point: 4.9038

>NTDB_id=340944 ETT73_RS02370 WP_002985645.1 425238..425948(+) (vicR) [Streptococcus pyogenes strain emm57]
MKKILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEEKPDLIILDLMLPELDGLEVAKEIRKTSHVPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTETIETAVAEENASSGTQELTIGNLQILPDAFVAKKHGQEVE
LTHREFELLHHLANHMGQVMTREHLLEIVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD

Nucleotide


Download         Length: 711 bp        

>NTDB_id=340944 ETT73_RS02370 WP_002985645.1 425238..425948(+) (vicR) [Streptococcus pyogenes strain emm57]
ATGAAAAAAATACTTATTGTGGATGATGAAAAACCGATTTCTGACATTATTAAGTTTAATTTGACAAAAGAAGGTTATGA
CATTGTTACAGCTTTTGATGGACGCGAAGCGGTAACAATTTTTGAAGAAGAAAAGCCAGATTTAATTATTCTTGATTTGA
TGCTCCCTGAGTTGGACGGTCTTGAAGTAGCCAAGGAAATTCGTAAAACCAGTCATGTCCCGATTATTATGTTGTCGGCT
AAAGATAGTGAGTTTGACAAGGTTATTGGACTTGAAATTGGGGCTGATGATTACGTGACCAAGCCCTTTTCTAATCGGGA
ATTGCTGGCGCGTGTCAAGGCTCATCTGCGTCGTACCGAAACTATTGAAACGGCTGTTGCAGAAGAAAATGCTTCTTCAG
GTACACAGGAACTAACCATTGGTAATTTACAGATTTTACCAGATGCGTTTGTTGCTAAAAAACATGGTCAAGAGGTAGAG
TTGACCCATCGTGAATTTGAACTATTGCATCATCTAGCTAACCATATGGGTCAGGTGATGACACGTGAACACTTATTGGA
AATTGTTTGGGGATATGATTATTTTGGCGATGTGCGCACGGTTGATGTGACTGTTCGTCGTCTTCGTGAAAAAATTGAAG
ACACACCAAGTCGTCCTGAGTATATTTTAACAAGACGTGGTGTTGGGTACTACATGAAATCTTATGACTAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-113)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(156-231)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicR Streptococcus mutans UA159

90.254

100

0.903
  micA Streptococcus pneumoniae Cp1015

79.06

99.153

0.784
  covR Streptococcus salivarius strain HSISS4

44.828

98.305

0.441
  covR Lactococcus lactis subsp. lactis strain DGCC12653

44.397

98.305

0.436
  scnR Streptococcus mutans UA159

36.91

98.729

0.364

Multiple sequence alignment