Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   F4V42_RS21220 Genome accession   NZ_CP044140
Coordinates   4054044..4054700 (+) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli O157 strain AR-0430     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 4049044..4059700
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  F4V42_RS21185 dcyD 4049923..4050909 (+) 987 WP_001128225.1 D-cysteine desulfhydrase -
  F4V42_RS21190 tcyL 4050924..4051592 (+) 669 WP_001158226.1 cystine ABC transporter permease -
  F4V42_RS21195 tcyN 4051589..4052341 (+) 753 WP_001273005.1 L-cystine ABC transporter ATP-binding protein TcyN -
  F4V42_RS21200 sdiA 4052571..4053293 (+) 723 WP_001154288.1 transcriptional regulator SdiA -
  F4V42_RS21205 yecF 4053361..4053585 (-) 225 WP_000106479.1 DUF2594 family protein YecF -
  F4V42_RS21210 yecU 4053572..4053748 (-) 177 WP_001302050.1 protein YecU -
  F4V42_RS30890 - 4053786..4053902 (-) 117 WP_001302039.1 hypothetical protein -
  F4V42_RS21220 letA 4054044..4054700 (+) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  F4V42_RS21225 uvrC 4054697..4056529 (+) 1833 WP_001283421.1 excinuclease ABC subunit UvrC Machinery gene
  F4V42_RS21230 pgsA 4056586..4057134 (+) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  F4V42_RS21250 - 4058126..4058407 (+) 282 WP_001303543.1 hypothetical protein -
  F4V42_RS21255 - 4058428..4058622 (+) 195 WP_115801851.1 hypothetical protein -
  F4V42_RS21260 - 4058564..4059697 (+) 1134 WP_032161728.1 IS30-like element IS30 family transposase -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=340945 F4V42_RS21220 WP_000611328.1 4054044..4054700(+) (letA) [Escherichia coli O157 strain AR-0430]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=340945 F4V42_RS21220 WP_000611328.1 4054044..4054700(+) (letA) [Escherichia coli O157 strain AR-0430]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGCCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTAAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATCCGTTCTGTCTATTCTGGGCAGCGTTACATTGCTTCTGACATCGCTCAACAAATGG
CATTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACGAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482

Multiple sequence alignment