Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   EQH19_RS10700 Genome accession   NZ_CP035261
Coordinates   2084458..2085639 (+) Length   393 a.a.
NCBI ID   WP_000681601.1    Uniprot ID   A0A0B7LRW6
Organism   Streptococcus pneumoniae strain TVO_1901924     
Function   degrading CSP; selective degradation of ComEA and ComEC (predicted from homology)   
Competence regulation

Genomic Context

Location: 2079458..2090639
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH19_RS10665 (EQH19_11255) comE 2079586..2080338 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  EQH19_RS10670 (EQH19_11260) comD 2080335..2080976 (-) 642 Protein_2080 competence system sensor histidine kinase ComD -
  EQH19_RS10675 (EQH19_11265) - 2081143..2082489 (+) 1347 WP_001808790.1 IS1380-like element ISSpn5 family transposase -
  EQH19_RS10680 (EQH19_11270) comD 2082682..2083368 (-) 687 Protein_2082 competence system sensor histidine kinase ComD -
  EQH19_RS10685 (EQH19_11275) comC/comC1 2083389..2083514 (-) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  EQH19_RS10695 (EQH19_11285) rlmH 2083796..2084275 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  EQH19_RS10700 (EQH19_11290) htrA 2084458..2085639 (+) 1182 WP_000681601.1 S1C family serine protease Regulator
  EQH19_RS10705 (EQH19_11295) spo0J 2085697..2086455 (+) 759 WP_000410378.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 393 a.a.        Molecular weight: 41855.70 Da        Isoelectric Point: 6.8902

>NTDB_id=338430 EQH19_RS10700 WP_000681601.1 2084458..2085639(+) (htrA) [Streptococcus pneumoniae strain TVO_1901924]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLRSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide


Download         Length: 1182 bp        

>NTDB_id=338430 EQH19_RS10700 WP_000681601.1 2084458..2085639(+) (htrA) [Streptococcus pneumoniae strain TVO_1901924]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTAGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAGATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAGTT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTGA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(103-248)

PDZ domain (PDZ_2)

(289-384)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7LRW6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus pneumoniae Rx1

99.491

100

0.995
  htrA Streptococcus pneumoniae D39

99.491

100

0.995
  htrA Streptococcus pneumoniae R6

99.491

100

0.995
  htrA Streptococcus pneumoniae TIGR4

99.491

100

0.995
  htrA Streptococcus mitis NCTC 12261

97.201

100

0.972
  htrA Streptococcus gordonii str. Challis substr. CH1

66.919

100

0.674
  htrA Streptococcus mutans UA159

54.822

100

0.55

Multiple sequence alignment