Detailed information NTG0338429

Bioinformatically predicted

Overview

• Name: comC/comC1
• Type: Regulator
• Locus tag: EQH19_RS10685
• Genome accession: NZ_CP035261
• Coordinates: 2083389..2083514 (-)
• Length: 41 a.a.
• NCBI ID: WP_000799689.1
• Uniprot ID: P60242
• Organism: Streptococcus pneumoniae strain TVO_1901924
• Function: binding to ComD; induce autophosphorylation of ComD (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	2081143..2082489	2083389..2083514	flank	900

Gene organization within MGE regions

Location: 2081143..2083514

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH19_RS10675 (EQH19_11265)	-	2081143..2082489 (+)	1347	WP_001808790.1	IS1380-like element ISSpn5 family transposase	-
EQH19_RS10680 (EQH19_11270)	comD	2082682..2083368 (-)	687	Protein_2082	competence system sensor histidine kinase ComD	-
EQH19_RS10685 (EQH19_11275)	comC/comC1	2083389..2083514 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator

Sequence

Protein

• Length: 41 a.a.
• Molecular weight: 4971.00 Da
• Isoelectric Point: 11.0775

>NTDB_id=338429 EQH19_RS10685 WP_000799689.1 2083389..2083514(-) (comC/comC1) [Streptococcus pneumoniae strain TVO_1901924]
MKNTVKLEQFVALKEKDLQKIKGGEMRLSKFFRDFILQRKK

Nucleotide

• Length: 126 bp

>NTDB_id=338429 EQH19_RS10685 WP_000799689.1 2083389..2083514(-) (comC/comC1) [Streptococcus pneumoniae strain TVO_1901924]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAAGATTAAAGGTGGGGAGATGAG
GTTGTCAAAATTCTTCCGTGATTTTATTTTACAAAGAAAAAAGTAA

Domains

Predicted by InterproScan.

• COMC family (ComC) (1-31)

3D structure

• PDB: 6CJ8
• PDB: 6COO
• PDB: 6COP
• PDB: 6COQ
• PDB: 6COR
• PDB: 6COS
• PDB: 6COW
• PDB: 6OBW
• PDB: 6OC2
• PDB: 6OC4
• PDB: 6OLD
• PDB: 6V1N

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comC/comC1	Streptococcus pneumoniae R6	100	100	1
comC/comC1	Streptococcus pneumoniae G54	100	100	1
comC/comC1	Streptococcus pneumoniae D39	100	100	1
comC/comC1	Streptococcus pneumoniae Rx1	100	100	1
comC/comC2	Streptococcus pneumoniae A66	80.488	100	0.805
comC/comC2	Streptococcus pneumoniae TIGR4	80.488	100	0.805
comC	Streptococcus mitis SK321	78.049	100	0.78
comC	Streptococcus mitis NCTC 12261	74.074	65.854	0.488
comC/blpC	Streptococcus mutans UA159	44.444	87.805	0.39