Detailed information NTG0338354

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: EQH20_RS10180
• Genome accession: NZ_CP035260
• Coordinates: 1997908..1999089 (+)
• Length: 393 a.a.
• NCBI ID: WP_000681598.1
• Uniprot ID: A0A0B7M448
• Organism: Streptococcus pneumoniae strain TVO_1901925
• Function: degrading CSP; selective degradation of ComEA and ComEC (predicted from homology) Competence regulation

Genomic Context

Location: 1992908..2004089

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH20_RS10140 (EQH20_10675)	-	1993959..1994501 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
EQH20_RS10155 (EQH20_10690)	comE	1994744..1995496 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
EQH20_RS10160 (EQH20_10695)	comD/comD1	1995493..1996818 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
EQH20_RS10165 (EQH20_10700)	comC/comC1	1996839..1996964 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
EQH20_RS10175 (EQH20_10710)	rlmH	1997246..1997725 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EQH20_RS10180 (EQH20_10715)	htrA	1997908..1999089 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
EQH20_RS10185 (EQH20_10720)	spo0J	1999147..1999905 (+)	759	WP_000410381.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41827.69 Da
• Isoelectric Point: 6.8902

>NTDB_id=338354 EQH20_RS10180 WP_000681598.1 1997908..1999089(+) (htrA) [Streptococcus pneumoniae strain TVO_1901925]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=338354 EQH20_RS10180 WP_000681598.1 1997908..1999089(+) (htrA) [Streptococcus pneumoniae strain TVO_1901925]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAAAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAAATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAGTT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

• PDZ domain (PDZ_2) (289-384)

3D structure

• AlphaFold DB: A0A0B7M448

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus pneumoniae Rx1	99.746	100	0.997
htrA	Streptococcus pneumoniae D39	99.746	100	0.997
htrA	Streptococcus pneumoniae R6	99.746	100	0.997
htrA	Streptococcus pneumoniae TIGR4	99.746	100	0.997
htrA	Streptococcus mitis NCTC 12261	97.455	100	0.975
htrA	Streptococcus gordonii str. Challis substr. CH1	66.667	100	0.672
htrA	Streptococcus mutans UA159	54.822	100	0.55