Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   EQH23_RS11135 Genome accession   NZ_CP035257
Coordinates   515200..515787 (-) Length   195 a.a.
NCBI ID   WP_001810228.1    Uniprot ID   A0A380LSF4
Organism   Streptococcus pneumoniae strain TVO_1901928     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 510200..520787
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH23_RS02570 (EQH23_02715) - 510664..512004 (+) 1341 WP_054372059.1 sensor histidine kinase -
  EQH23_RS02575 (EQH23_02720) blpC 512046..512201 (-) 156 WP_000358817.1 quorum-sensing system pheromone BlpC -
  EQH23_RS02580 (EQH23_02725) - 512258..513619 (-) 1362 WP_001069091.1 bacteriocin secretion accessory protein -
  EQH23_RS02585 (EQH23_02730) comA/nlmT 513630..515306 (-) 1677 WP_196299874.1 peptide cleavage/export ABC transporter Regulator
  EQH23_RS11135 comA/nlmT 515200..515787 (-) 588 WP_001810228.1 cysteine peptidase family C39 domain-containing protein Regulator
  EQH23_RS02590 (EQH23_02735) blpI 516069..516266 (+) 198 WP_001093259.1 bacteriocin-like peptide BlpI -
  EQH23_RS02595 (EQH23_02745) blpJ 516733..517002 (+) 270 WP_001093248.1 bacteriocin-like peptide BlpJ -
  EQH23_RS02600 (EQH23_02750) blpU 517071..517301 (+) 231 WP_000379964.1 bacteriocin-like peptide BlpU -
  EQH23_RS02605 (EQH23_02755) - 517304..517423 (+) 120 WP_000346298.1 PncF family bacteriocin immunity protein -
  EQH23_RS02610 (EQH23_02760) - 517720..517884 (+) 165 WP_000727118.1 hypothetical protein -
  EQH23_RS02615 (EQH23_02765) - 517881..518285 (+) 405 WP_000846944.1 hypothetical protein -
  EQH23_RS02620 (EQH23_02770) - 518483..519287 (+) 805 Protein_523 IS5 family transposase -
  EQH23_RS02625 (EQH23_02775) blpM 519437..519691 (+) 255 WP_000379879.1 two-peptide bacteriocin subunit BlpM -
  EQH23_RS02630 (EQH23_02780) blpN 519707..519910 (+) 204 WP_001099492.1 two-peptide bacteriocin subunit BlpN -
  EQH23_RS02635 (EQH23_02790) cipB 520154..520303 (+) 150 WP_001809846.1 bacteriocin-like peptide BlpO Regulator
  EQH23_RS02640 (EQH23_02795) - 520407..520526 (+) 120 WP_000346296.1 PncF family bacteriocin immunity protein -

Sequence

Protein


Download         Length: 195 a.a.        Molecular weight: 22369.84 Da        Isoelectric Point: 9.7306

>NTDB_id=338125 EQH23_RS11135 WP_001810228.1 515200..515787(-) (comA/nlmT) [Streptococcus pneumoniae strain TVO_1901928]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLR

Nucleotide


Download         Length: 588 bp        

>NTDB_id=338125 EQH23_RS11135 WP_001810228.1 515200..515787(-) (comA/nlmT) [Streptococcus pneumoniae strain TVO_1901928]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTAGATGA

Domains

Predicted by InterproScan.

Peptidase C39 family (Peptidase_C39)

(7-142)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A380LSF4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

59.89

93.333

0.559
  comA Streptococcus mitis NCTC 12261

54.891

94.359

0.518
  comA Streptococcus mitis SK321

54.348

94.359

0.513
  comA Streptococcus pneumoniae TIGR4

53.804

94.359

0.508
  comA Streptococcus pneumoniae Rx1

53.804

94.359

0.508
  comA Streptococcus pneumoniae D39

53.804

94.359

0.508
  comA Streptococcus pneumoniae R6

53.804

94.359

0.508
  comA Streptococcus gordonii str. Challis substr. CH1

52.717

94.359

0.497

Multiple sequence alignment