Detailed information NTG0337912

Bioinformatically predicted

Overview

• Name: dprA/cilB/dalA
• Type: Machinery gene
• Locus tag: EQH26_RS05965
• Genome accession: NZ_CP035254
• Coordinates: 1186741..1187589 (-)
• Length: 282 a.a.
• NCBI ID: WP_000705304.1
• Uniprot ID: A0A0E7P1X9
• Organism: Streptococcus pneumoniae strain TVO_1901932
• Function: ssDNA binding; loading RecA onto ssDNA; competence shut-off (predicted from homology) DNA processing Competence regulation

Genomic Context

Location: 1181741..1192589

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH26_RS05950 (EQH26_06300)	-	1182096..1182455 (-)	360	WP_001237218.1	YbaN family protein	-
EQH26_RS05955 (EQH26_06305)	topA	1182561..1184648 (-)	2088	WP_054369609.1	type I DNA topoisomerase	-
EQH26_RS05960 (EQH26_06310)	-	1184815..1185858 (-)	1044	WP_001812957.1	TIGR00341 family protein	-
EQH26_RS10865	-	1186436..1186558 (+)	123	WP_001814242.1	hypothetical protein	-
EQH26_RS05965 (EQH26_06315)	dprA/cilB/dalA	1186741..1187589 (-)	849	WP_000705304.1	DNA-processing protein DprA	Machinery gene
EQH26_RS05970 (EQH26_06320)	-	1187687..1188376 (-)	690	WP_000643965.1	sugar phosphate nucleotidyltransferase	-
EQH26_RS05975 (EQH26_06325)	-	1188388..1189266 (-)	879	WP_000837609.1	DMT family transporter	-
EQH26_RS05980 (EQH26_06330)	licA	1189256..1190125 (-)	870	WP_000411207.1	choline kinase LicA	-
EQH26_RS05985 (EQH26_06335)	-	1190142..1191164 (-)	1023	WP_000609888.1	ribitol-5-phosphate dehydrogenase	-
EQH26_RS05990 (EQH26_06340)	-	1191169..1191876 (-)	708	WP_000638482.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-

Sequence

Protein

• Length: 282 a.a.
• Molecular weight: 31076.75 Da
• Isoelectric Point: 5.4047

>NTDB_id=337912 EQH26_RS05965 WP_000705304.1 1186741..1187589(-) (dprA/cilB/dalA) [Streptococcus pneumoniae strain TVO_1901932]
MKITNYEIYKLKKSGLTNQQILKVLEYGENVDQELLLGDIADISGCRNPAVFMERYFQIDDAHLSKEFQKFPSFSILDDC
YPWDLSEIYDAPVLLFYKGNLDLLKFPKVAVVGSRACSKQGAKSVEKVIQGLENELVIVSGLAKGIDTAAHMAALQNGGK
TIAVIGTGLDVFYPKANKRLQDYIGNDHLVLSEYGPGEQPLKFHFPARNRIIAGLCRGVIVAEAKMRSGSLITCERAMEE
GRDVFAIPGSILDGLSDGCHHLIQEGAKLLTSGQDVLAEFEF

Nucleotide

• Length: 849 bp

>NTDB_id=337912 EQH26_RS05965 WP_000705304.1 1186741..1187589(-) (dprA/cilB/dalA) [Streptococcus pneumoniae strain TVO_1901932]
ATGAAAATCACAAACTATGAAATCTATAAGTTAAAAAAATCAGGTTTGACCAATCAACAGATTTTGAAAGTGCTAGAATA
CGGTGAAAATGTTGATCAGGAGCTTTTGTTGGGTGATATTGCAGATATATCAGGTTGCCGTAATCCAGCCGTTTTTATGG
AACGTTATTTTCAGATAGACGATGCGCATTTGTCGAAAGAGTTTCAAAAATTTCCATCTTTCTCTATTTTAGATGACTGT
TATCCTTGGGATTTGAGTGAAATATATGATGCGCCTGTACTTTTATTTTACAAGGGAAATCTTGACCTCCTGAAATTCCC
GAAGGTAGCGGTCGTGGGCAGTCGTGCTTGTAGCAAACAGGGAGCTAAATCAGTTGAAAAAGTCATTCAAGGCTTGGAAA
ATGAACTGGTTATTGTCAGTGGTCTGGCCAAGGGCATTGACACAGCAGCTCATATGGCAGCTCTTCAGAATGGCGGAAAA
ACCATTGCAGTGATTGGAACAGGACTGGATGTGTTTTATCCTAAAGCCAATAAACGCTTGCAAGACTACATCGGCAATGA
CCATCTGGTTCTAAGTGAATATGGACCTGGCGAACAACCTCTGAAATTTCATTTTCCTGCCCGTAATCGCATCATTGCTG
GACTTTGTCGTGGTGTGATTGTAGCAGAGGCTAAGATGCGTTCAGGTAGTCTCATTACGTGTGAGCGAGCAATGGAAGAA
GGACGCGATGTCTTTGCTATTCCTGGTAGCATTTTAGATGGACTATCAGACGGTTGCCATCATTTGATTCAAGAAGGAGC
AAAATTGCTCACCAGTGGGCAAGATGTTCTTGCGGAATTTGAATTTTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (75-271)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (3-64)

3D structure

• AlphaFold DB: A0A0E7P1X9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	99.645	100	0.996
dprA/cilB/dalA	Streptococcus pneumoniae D39	99.645	100	0.996
dprA/cilB/dalA	Streptococcus pneumoniae R6	99.645	100	0.996
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	99.645	100	0.996
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	98.227	100	0.982
dprA/cilB/dalA	Streptococcus mitis SK321	97.518	100	0.975
dprA	Streptococcus mutans UA159	63.214	99.291	0.628
dprA	Lactococcus lactis subsp. cremoris KW2	55.357	99.291	0.55
dprA	Staphylococcus aureus N315	37.456	100	0.376