Detailed information NTG0337722

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: EQH31_RS11120
• Genome accession: NZ_CP035249
• Coordinates: 498493..499080 (-)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain TVO_1901938
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 493493..504080

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH31_RS02510 (EQH31_02680)	-	493943..495283 (+)	1341	WP_001099892.1	sensor histidine kinase	-
EQH31_RS02515 (EQH31_02685)	blpC	495327..495482 (-)	156	WP_000358811.1	quorum-sensing system pheromone BlpC	-
EQH31_RS02520 (EQH31_02690)	-	495539..496900 (-)	1362	WP_001069071.1	bacteriocin secretion accessory protein	-
EQH31_RS02525 (EQH31_02695)	comA/nlmT	496911..498401 (-)	1491	WP_001818755.1	peptide cleavage/export ABC transporter	Regulator
EQH31_RS11120 (EQH31_02700)	comA/nlmT	498493..499080 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
EQH31_RS02530 (EQH31_02705)	blpI	499362..499559 (+)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
EQH31_RS02535 (EQH31_02715)	blpJ	500026..500295 (+)	270	WP_001093248.1	bacteriocin-like peptide BlpJ	-
EQH31_RS02540 (EQH31_02720)	blpU	500364..500594 (+)	231	WP_000379964.1	bacteriocin-like peptide BlpU	-
EQH31_RS02545 (EQH31_02725)	-	500597..500716 (+)	120	WP_001844187.1	PncF family bacteriocin immunity protein	-
EQH31_RS02550 (EQH31_02730)	-	501015..501179 (+)	165	WP_000727118.1	hypothetical protein	-
EQH31_RS02555 (EQH31_02735)	-	501176..501571 (+)	396	WP_000846569.1	hypothetical protein	-
EQH31_RS02560 (EQH31_02740)	-	501585..502399 (-)	815	Protein_512	IS5-like element IS1515 family transposase	-
EQH31_RS02565 (EQH31_02750)	-	502656..503460 (+)	805	WP_128887636.1	IS5 family transposase	-
EQH31_RS02570 (EQH31_02755)	blpM	503610..503864 (+)	255	WP_000379879.1	two-peptide bacteriocin subunit BlpM	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=337722 EQH31_RS11120 WP_000205166.1 498493..499080(-) (comA/nlmT) [Streptococcus pneumoniae strain TVO_1901938]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=337722 EQH31_RS11120 WP_000205166.1 498493..499080(-) (comA/nlmT) [Streptococcus pneumoniae strain TVO_1901938]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497