Detailed information
Bioinformatically predicted
Overview
| Name | comB | Type | Regulator |
| Locus tag | EQH35_RS00460 | Genome accession | NZ_CP035245 |
| Coordinates | 76438..77787 (+) | Length | 449 a.a. |
| NCBI ID | WP_000801618.1 | Uniprot ID | - |
| Organism | Streptococcus pneumoniae strain TVO_1901943 | ||
| Function | transport of ComC (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 12174..87892 | 76438..77787 | within | 0 |
Gene organization within MGE regions
Location: 12174..87892
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EQH35_RS00060 (EQH35_00060) | ftsH | 12174..14132 (+) | 1959 | WP_000744554.1 | ATP-dependent zinc metalloprotease FtsH | - |
| EQH35_RS00065 (EQH35_00065) | comX/comX2 | 14254..14733 (+) | 480 | WP_000588866.1 | sigma-70 family RNA polymerase sigma factor | Regulator |
| EQH35_RS00100 (EQH35_00105) | - | 20283..20492 (+) | 210 | Protein_14 | transposase | - |
| EQH35_RS00105 (EQH35_00110) | - | 20527..21324 (-) | 798 | Protein_15 | transposase | - |
| EQH35_RS00110 (EQH35_00115) | comW | 21590..21826 (+) | 237 | WP_000939546.1 | sigma(X)-activator ComW | Regulator |
| EQH35_RS00115 (EQH35_00120) | - | 22057..23343 (+) | 1287 | WP_000205044.1 | adenylosuccinate synthase | - |
| EQH35_RS00120 (EQH35_00125) | - | 23585..24733 (-) | 1149 | WP_000876732.1 | site-specific integrase | - |
| EQH35_RS00125 (EQH35_00135) | - | 24919..25842 (-) | 924 | WP_000122591.1 | exonuclease domain-containing protein | - |
| EQH35_RS00130 (EQH35_00140) | - | 25855..26238 (-) | 384 | WP_000136459.1 | ImmA/IrrE family metallo-endopeptidase | - |
| EQH35_RS00135 (EQH35_00145) | - | 26251..26616 (-) | 366 | WP_000492031.1 | helix-turn-helix domain-containing protein | - |
| EQH35_RS00140 (EQH35_00150) | - | 26993..27214 (-) | 222 | WP_000041097.1 | hypothetical protein | - |
| EQH35_RS00145 | - | 27333..27479 (+) | 147 | WP_000389576.1 | hypothetical protein | - |
| EQH35_RS00150 (EQH35_00155) | - | 27491..27694 (+) | 204 | WP_000032097.1 | helix-turn-helix transcriptional regulator | - |
| EQH35_RS00155 (EQH35_00160) | - | 27711..27908 (+) | 198 | WP_001057654.1 | hypothetical protein | - |
| EQH35_RS00160 | - | 27919..28080 (+) | 162 | WP_001002946.1 | hypothetical protein | - |
| EQH35_RS00165 (EQH35_00165) | - | 28075..28500 (-) | 426 | WP_000386249.1 | hypothetical protein | - |
| EQH35_RS00170 (EQH35_00170) | - | 28554..29264 (+) | 711 | WP_001002359.1 | ORF6C domain-containing protein | - |
| EQH35_RS00175 (EQH35_00175) | - | 29278..29535 (+) | 258 | WP_000370959.1 | hypothetical protein | - |
| EQH35_RS00180 (EQH35_00180) | - | 29621..29941 (+) | 321 | WP_000462824.1 | hypothetical protein | - |
| EQH35_RS00185 (EQH35_00185) | - | 29957..30253 (+) | 297 | WP_000391805.1 | hypothetical protein | - |
| EQH35_RS00190 (EQH35_00190) | - | 30246..31052 (+) | 807 | WP_001289771.1 | phage replisome organizer N-terminal domain-containing protein | - |
| EQH35_RS00195 (EQH35_00195) | - | 31192..31962 (+) | 771 | WP_000228219.1 | ATP-binding protein | - |
| EQH35_RS10680 (EQH35_00200) | - | 31977..32171 (+) | 195 | WP_000470307.1 | hypothetical protein | - |
| EQH35_RS00200 (EQH35_00205) | - | 32171..32389 (+) | 219 | WP_000891962.1 | hypothetical protein | - |
| EQH35_RS00205 (EQH35_00210) | - | 32771..32869 (+) | 99 | Protein_36 | single-stranded DNA-binding protein | - |
| EQH35_RS00210 (EQH35_00215) | - | 32883..33050 (+) | 168 | WP_000233203.1 | hypothetical protein | - |
| EQH35_RS00215 (EQH35_00220) | - | 33037..33246 (+) | 210 | WP_000872740.1 | hypothetical protein | - |
| EQH35_RS00220 (EQH35_00225) | - | 33218..33535 (+) | 318 | WP_000969665.1 | hypothetical protein | - |
| EQH35_RS00225 | - | 33537..33611 (+) | 75 | Protein_40 | DUF1642 domain-containing protein | - |
| EQH35_RS00230 (EQH35_00230) | - | 33788..34189 (+) | 402 | WP_000736390.1 | transcriptional activator | - |
| EQH35_RS00235 (EQH35_00235) | - | 34377..34919 (+) | 543 | WP_000397549.1 | site-specific integrase | - |
| EQH35_RS00240 (EQH35_00240) | - | 35296..35616 (+) | 321 | WP_000282427.1 | HNH endonuclease | - |
| EQH35_RS00245 (EQH35_00245) | - | 35753..36145 (+) | 393 | WP_001118283.1 | P27 family phage terminase small subunit | - |
| EQH35_RS00250 (EQH35_00250) | - | 36138..37868 (+) | 1731 | WP_000527299.1 | terminase large subunit | - |
| EQH35_RS00255 (EQH35_00255) | - | 37876..38094 (+) | 219 | WP_001002923.1 | hypothetical protein | - |
| EQH35_RS00260 (EQH35_00260) | - | 38112..39314 (+) | 1203 | WP_000510803.1 | phage portal protein | - |
| EQH35_RS00265 (EQH35_00265) | - | 39298..39873 (+) | 576 | WP_001172115.1 | HK97 family phage prohead protease | - |
| EQH35_RS00270 (EQH35_00270) | - | 39870..41036 (+) | 1167 | WP_001030357.1 | phage major capsid protein | - |
| EQH35_RS00275 (EQH35_00275) | - | 41048..41317 (+) | 270 | WP_000262606.1 | hypothetical protein | - |
| EQH35_RS00280 (EQH35_00280) | - | 41320..41601 (+) | 282 | WP_000370976.1 | hypothetical protein | - |
| EQH35_RS00285 (EQH35_00285) | - | 41588..41887 (+) | 300 | WP_000267055.1 | phage head closure protein | - |
| EQH35_RS00290 (EQH35_00290) | - | 41884..42231 (+) | 348 | WP_000063886.1 | HK97 gp10 family phage protein | - |
| EQH35_RS00295 (EQH35_00295) | - | 42228..42551 (+) | 324 | WP_000777003.1 | hypothetical protein | - |
| EQH35_RS00300 (EQH35_00300) | - | 42563..43141 (+) | 579 | WP_000191279.1 | major tail protein | - |
| EQH35_RS00305 (EQH35_00305) | - | 43153..43572 (+) | 420 | WP_001227146.1 | hypothetical protein | - |
| EQH35_RS00310 (EQH35_00310) | - | 43850..46945 (+) | 3096 | WP_000918318.1 | hypothetical protein | - |
| EQH35_RS00315 (EQH35_00315) | - | 46942..47664 (+) | 723 | WP_000589856.1 | hypothetical protein | - |
| EQH35_RS00320 | - | 47665..54297 (+) | 6633 | WP_000966215.1 | phage tail spike protein | - |
| EQH35_RS10685 | - | 54294..54410 (+) | 117 | WP_001063632.1 | hypothetical protein | - |
| EQH35_RS00325 (EQH35_00335) | - | 54391..54594 (+) | 204 | WP_001091113.1 | hypothetical protein | - |
| EQH35_RS00330 (EQH35_00340) | - | 54597..54947 (+) | 351 | WP_000852241.1 | hypothetical protein | - |
| EQH35_RS00335 (EQH35_00345) | - | 54956..55372 (+) | 417 | WP_001165344.1 | phage holin family protein | - |
| EQH35_RS00340 (EQH35_00350) | - | 55376..55708 (+) | 333 | WP_001186219.1 | phage holin | - |
| EQH35_RS00345 (EQH35_00355) | - | 55712..56668 (+) | 957 | WP_000350505.1 | N-acetylmuramoyl-L-alanine amidase family protein | - |
| EQH35_RS00350 (EQH35_00360) | - | 56889..57077 (-) | 189 | WP_000109850.1 | hypothetical protein | - |
| EQH35_RS00355 (EQH35_00365) | tadA | 57645..58112 (+) | 468 | WP_000291870.1 | tRNA adenosine(34) deaminase TadA | - |
| EQH35_RS00365 (EQH35_00375) | - | 58298..58741 (+) | 444 | WP_000701992.1 | dUTP diphosphatase | - |
| EQH35_RS00370 (EQH35_00380) | - | 58743..59258 (+) | 516 | WP_001838385.1 | histidine phosphatase family protein | - |
| EQH35_RS00375 (EQH35_00385) | radA | 59272..60633 (+) | 1362 | WP_074017595.1 | DNA repair protein RadA | Machinery gene |
| EQH35_RS00380 (EQH35_00390) | - | 60706..61203 (+) | 498 | WP_001809263.1 | carbonic anhydrase | - |
| EQH35_RS00385 (EQH35_00400) | - | 61228..62058 (+) | 831 | Protein_72 | PrsW family glutamic-type intramembrane protease | - |
| EQH35_RS00390 (EQH35_00405) | - | 62203..63171 (+) | 969 | WP_000010163.1 | ribose-phosphate diphosphokinase | - |
| EQH35_RS00395 (EQH35_00410) | - | 63308..63586 (-) | 279 | Protein_74 | transposase family protein | - |
| EQH35_RS00400 | - | 63630..64555 (-) | 926 | Protein_75 | Rpn family recombination-promoting nuclease/putative transposase | - |
| EQH35_RS00405 (EQH35_00430) | polA | 64811..67444 (+) | 2634 | WP_001809267.1 | DNA polymerase I | - |
| EQH35_RS00410 (EQH35_00435) | - | 67529..67966 (+) | 438 | WP_000076479.1 | CoA-binding protein | - |
| EQH35_RS00415 | - | 68007..68435 (+) | 429 | WP_000693134.1 | hypothetical protein | - |
| EQH35_RS00420 (EQH35_00440) | - | 68464..69474 (-) | 1011 | WP_000009171.1 | YeiH family protein | - |
| EQH35_RS00425 (EQH35_00445) | - | 69623..70792 (+) | 1170 | WP_000366345.1 | pyridoxal phosphate-dependent aminotransferase | - |
| EQH35_RS00430 (EQH35_00450) | recO | 70789..71559 (+) | 771 | WP_000616162.1 | DNA repair protein RecO | - |
| EQH35_RS00435 (EQH35_00455) | plsX | 71556..72548 (+) | 993 | WP_000717457.1 | phosphate acyltransferase PlsX | - |
| EQH35_RS00440 (EQH35_00460) | - | 72554..72787 (+) | 234 | WP_000659556.1 | acyl carrier protein | - |
| EQH35_RS00445 (EQH35_00465) | - | 72824..73124 (+) | 301 | Protein_84 | transposase family protein | - |
| EQH35_RS00450 (EQH35_00470) | blpU | 73327..73557 (+) | 231 | Protein_85 | bacteriocin-like peptide BlpU | - |
| EQH35_RS10585 | - | 73560..73685 (+) | 126 | WP_000346297.1 | PncF family bacteriocin immunity protein | - |
| EQH35_RS00455 (EQH35_00475) | comA | 74272..76425 (+) | 2154 | WP_000668304.1 | peptide cleavage/export ABC transporter ComA | Regulator |
| EQH35_RS00460 (EQH35_00480) | comB | 76438..77787 (+) | 1350 | WP_000801618.1 | competence pheromone export protein ComB | Regulator |
| EQH35_RS00465 (EQH35_00485) | purC | 77957..78664 (+) | 708 | WP_000043304.1 | phosphoribosylaminoimidazolesuccinocarboxamide synthase | - |
| EQH35_RS10690 (EQH35_00490) | - | 78666..78809 (+) | 144 | WP_050167432.1 | hypothetical protein | - |
| EQH35_RS00470 (EQH35_00495) | - | 78866..82591 (+) | 3726 | WP_000361178.1 | phosphoribosylformylglycinamidine synthase | - |
| EQH35_RS00475 (EQH35_00500) | purF | 82684..84126 (+) | 1443 | WP_000220633.1 | amidophosphoribosyltransferase | - |
| EQH35_RS00480 (EQH35_00505) | purM | 84163..85185 (+) | 1023 | WP_000182558.1 | phosphoribosylformylglycinamidine cyclo-ligase | - |
| EQH35_RS00485 (EQH35_00510) | purN | 85182..85727 (+) | 546 | WP_000717506.1 | phosphoribosylglycinamide formyltransferase | - |
| EQH35_RS00490 (EQH35_00515) | - | 85811..86320 (+) | 510 | WP_000894018.1 | VanZ family protein | - |
| EQH35_RS00495 (EQH35_00520) | purH | 86345..87892 (+) | 1548 | WP_000167082.1 | bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase | - |
Sequence
Protein
Download Length: 449 a.a. Molecular weight: 49615.49 Da Isoelectric Point: 5.3895
>NTDB_id=337339 EQH35_RS00460 WP_000801618.1 76438..77787(+) (comB) [Streptococcus pneumoniae strain TVO_1901943]
MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEMSLSTRATVEPSRILANIQSTSNNRILVNHLEENKL
VKKGDLLVQYQEGAEGVQAESYASQLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQN
ETIASQNAAASQTQAEIGNLISQTEAKIRDYQTAKSAMETGASLASQNLAYSLYQSYKSQGEENPQTKVQAVAQVEAQIS
QLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKVGQELTLLAQKILEAESGKKVQGNLLDKGKITASEDGVLH
LNPETSDSSMVAEGALLAQLYPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTEK
GNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE
MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEMSLSTRATVEPSRILANIQSTSNNRILVNHLEENKL
VKKGDLLVQYQEGAEGVQAESYASQLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQN
ETIASQNAAASQTQAEIGNLISQTEAKIRDYQTAKSAMETGASLASQNLAYSLYQSYKSQGEENPQTKVQAVAQVEAQIS
QLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKVGQELTLLAQKILEAESGKKVQGNLLDKGKITASEDGVLH
LNPETSDSSMVAEGALLAQLYPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTEK
GNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE
Nucleotide
Download Length: 1350 bp
>NTDB_id=337339 EQH35_RS00460 WP_000801618.1 76438..77787(+) (comB) [Streptococcus pneumoniae strain TVO_1901943]
ATGAAACCAGAATTTTTAGAAAGTGCGGAGTTTTATAATCGTCGTTACCATAATTTTTCCAGTAGTGTGATTGTACCCAT
GGCCCTTCTGCTCGTGTTTTTACTTGGCTTTGCAACTGTTGCAGAAAAGGAGATGAGTTTGTCCACTAGAGCTACTGTCG
AACCTAGTCGTATCCTTGCAAATATCCAGTCAACTAGCAACAATCGTATTCTTGTCAATCATTTGGAAGAAAATAAGCTG
GTTAAGAAGGGGGATCTTTTGGTTCAATACCAAGAAGGGGCAGAGGGTGTCCAAGCGGAGTCCTATGCCAGTCAGTTGGA
CATGCTAAAGGATCAAAAAAAGCAATTGGAGTATCTGCAAAAGAGCCTGCAAGAAGGGGAGAACCACTTTCCAGAGGAGG
ATAAGTTTGGCTACCAAGCCACCTTTCGCGACTACATCAGTCAAGCAGGCAGTCTTAGGGCTAGTACATCGCAACAAAAT
GAGACCATCGCGTCCCAGAATGCAGCAGCTAGCCAAACCCAAGCCGAAATCGGCAACCTCATCAGTCAAACAGAGGCTAA
AATTCGCGATTACCAGACAGCTAAGTCAGCTATGGAAACAGGTGCTTCCTTGGCCAGTCAGAATCTAGCCTACTCTCTTT
ACCAGTCCTACAAGTCTCAGGGCGAGGAAAATCCCCAAACTAAGGTTCAGGCAGTTGCACAGGTTGAAGCACAGATTTCT
CAGTTAGAATCTAGTCTTGCTACTTACCGTGTCCAGTATGCAGGTTCAGGTACCCAGCAAGCCTATGCGTCAGGGTTAAG
CAGTCAATTGGAATCCCTTAAATCCCAACATTTGGCAAAGGTTGGTCAGGAATTGACCCTTCTAGCCCAGAAAATCTTGG
AGGCAGAGTCAGGTAAGAAGGTACAGGGAAATCTTTTAGACAAGGGGAAAATTACGGCGAGTGAGGATGGGGTGCTTCAT
CTTAATCCTGAGACCAGTGATTCTAGCATGGTTGCAGAAGGTGCCCTACTAGCCCAACTTTATCCATCTTTGGAAAGAGA
AGGGAAAGCCAAACTCACAGCCTATCTAAGTTCAAAAGATGTAGCAAGAATCAAGGTCGGTGATTCTGTTCGCTATACTA
CGACTCATGATGCCGGGAATCAACTTTTCCTAGATTCAACTATTACAAGTATTGATGCGACAGCTACTAAGACTGAGAAA
GGGAATTTCTTTAAAATCGAGGCGGAGACTAATCTAACTTCGGAGCAGGCTGAAAAACTTAGGTACGGGGTGGAAGGCCG
CTTGCAGATGATTACGGGCAAGAAAAGTTATCTACGTTATTATTTGGATCAATTTTTGAACAAAGAGTAA
ATGAAACCAGAATTTTTAGAAAGTGCGGAGTTTTATAATCGTCGTTACCATAATTTTTCCAGTAGTGTGATTGTACCCAT
GGCCCTTCTGCTCGTGTTTTTACTTGGCTTTGCAACTGTTGCAGAAAAGGAGATGAGTTTGTCCACTAGAGCTACTGTCG
AACCTAGTCGTATCCTTGCAAATATCCAGTCAACTAGCAACAATCGTATTCTTGTCAATCATTTGGAAGAAAATAAGCTG
GTTAAGAAGGGGGATCTTTTGGTTCAATACCAAGAAGGGGCAGAGGGTGTCCAAGCGGAGTCCTATGCCAGTCAGTTGGA
CATGCTAAAGGATCAAAAAAAGCAATTGGAGTATCTGCAAAAGAGCCTGCAAGAAGGGGAGAACCACTTTCCAGAGGAGG
ATAAGTTTGGCTACCAAGCCACCTTTCGCGACTACATCAGTCAAGCAGGCAGTCTTAGGGCTAGTACATCGCAACAAAAT
GAGACCATCGCGTCCCAGAATGCAGCAGCTAGCCAAACCCAAGCCGAAATCGGCAACCTCATCAGTCAAACAGAGGCTAA
AATTCGCGATTACCAGACAGCTAAGTCAGCTATGGAAACAGGTGCTTCCTTGGCCAGTCAGAATCTAGCCTACTCTCTTT
ACCAGTCCTACAAGTCTCAGGGCGAGGAAAATCCCCAAACTAAGGTTCAGGCAGTTGCACAGGTTGAAGCACAGATTTCT
CAGTTAGAATCTAGTCTTGCTACTTACCGTGTCCAGTATGCAGGTTCAGGTACCCAGCAAGCCTATGCGTCAGGGTTAAG
CAGTCAATTGGAATCCCTTAAATCCCAACATTTGGCAAAGGTTGGTCAGGAATTGACCCTTCTAGCCCAGAAAATCTTGG
AGGCAGAGTCAGGTAAGAAGGTACAGGGAAATCTTTTAGACAAGGGGAAAATTACGGCGAGTGAGGATGGGGTGCTTCAT
CTTAATCCTGAGACCAGTGATTCTAGCATGGTTGCAGAAGGTGCCCTACTAGCCCAACTTTATCCATCTTTGGAAAGAGA
AGGGAAAGCCAAACTCACAGCCTATCTAAGTTCAAAAGATGTAGCAAGAATCAAGGTCGGTGATTCTGTTCGCTATACTA
CGACTCATGATGCCGGGAATCAACTTTTCCTAGATTCAACTATTACAAGTATTGATGCGACAGCTACTAAGACTGAGAAA
GGGAATTTCTTTAAAATCGAGGCGGAGACTAATCTAACTTCGGAGCAGGCTGAAAAACTTAGGTACGGGGTGGAAGGCCG
CTTGCAGATGATTACGGGCAAGAAAAGTTATCTACGTTATTATTTGGATCAATTTTTGAACAAAGAGTAA
Domains
No domain identified.
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comB | Streptococcus pneumoniae TIGR4 |
99.109 |
100 |
0.991 |
| comB | Streptococcus pneumoniae Rx1 |
98.886 |
100 |
0.989 |
| comB | Streptococcus pneumoniae D39 |
98.886 |
100 |
0.989 |
| comB | Streptococcus pneumoniae R6 |
98.886 |
100 |
0.989 |
| comB | Streptococcus mitis SK321 |
95.1 |
100 |
0.951 |
| comB | Streptococcus mitis NCTC 12261 |
94.655 |
100 |
0.947 |
| comB | Streptococcus gordonii str. Challis substr. CH1 |
55.333 |
100 |
0.555 |