Detailed information NTG0337145

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: EQH38_RS06025
• Genome accession: NZ_CP035242
• Coordinates: 1138434..1139138 (+)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae strain TVO_1901947
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1133434..1144138

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH38_RS06005 (EQH38_06340)	coaC	1133724..1134275 (-)	552	WP_001284128.1	phosphopantothenoylcysteine decarboxylase	-
EQH38_RS06010 (EQH38_06345)	coaB	1134287..1134976 (-)	690	WP_000699503.1	phosphopantothenate--cysteine ligase	-
EQH38_RS06015 (EQH38_06350)	-	1135206..1136876 (+)	1671	WP_044727479.1	formate--tetrahydrofolate ligase	-
EQH38_RS10790	-	1136982..1137107 (-)	126	WP_001818232.1	hypothetical protein	-
EQH38_RS06020 (EQH38_06355)	mutY	1137204..1138379 (+)	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
EQH38_RS06025 (EQH38_06360)	micA	1138434..1139138 (+)	705	WP_000722076.1	response regulator YycF	Regulator
EQH38_RS06030 (EQH38_06365)	micB	1139131..1140480 (+)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
EQH38_RS06035 (EQH38_06370)	vicX	1140482..1141291 (+)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
EQH38_RS06040 (EQH38_06375)	relB	1141382..1141624 (+)	243	WP_000208080.1	type II toxin-antitoxin system RelB family antitoxin	-
EQH38_RS06045 (EQH38_06380)	-	1141626..1141880 (+)	255	WP_001809704.1	type II toxin-antitoxin system RelE/ParE family toxin	-
EQH38_RS06050 (EQH38_06385)	-	1141955..1143826 (+)	1872	WP_000150982.1	Eco57I restriction-modification methylase domain-containing protein	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=337145 EQH38_RS06025 WP_000722076.1 1138434..1139138(+) (micA) [Streptococcus pneumoniae strain TVO_1901947]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=337145 EQH38_RS06025 WP_000722076.1 1138434..1139138(+) (micA) [Streptococcus pneumoniae strain TVO_1901947]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCACGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGGCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38