Detailed information NTG0033533

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: SEQ_RS08290
• Genome accession: NC_012471
• Coordinates: 1720204..1722360 (+)
• Length: 718 a.a.
• NCBI ID: WP_012679943.1
• Uniprot ID: C0MC58
• Organism: Streptococcus equi subsp. equi 4047
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1715204..1727360

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SEQ_RS08255 (SEQ_1701)	-	1715670..1716083 (-)	414	WP_012679937.1	hypothetical protein	-
SEQ_RS08270 (SEQ_1705)	-	1718177..1718380 (-)	204	WP_012679939.1	bacteriocin	-
SEQ_RS08275 (SEQ_1706)	-	1718397..1718651 (-)	255	WP_012679940.1	Blp family class II bacteriocin	-
SEQ_RS08280 (SEQ_1707)	-	1719393..1719689 (-)	297	WP_042357490.1	bacteriocin immunity protein	-
SEQ_RS08285 (SEQ_1708)	-	1719696..1719944 (-)	249	WP_012679942.1	garvicin Q family class II bacteriocin	-
SEQ_RS08290 (SEQ_1709)	comA/nlmT	1720204..1722360 (+)	2157	WP_012679943.1	peptide cleavage/export ABC transporter	Regulator
SEQ_RS08295 (SEQ_1710)	-	1722371..1723729 (+)	1359	WP_012679944.1	bacteriocin secretion accessory protein	-
SEQ_RS08300 (SEQ_1710a)	-	1723829..1723960 (+)	132	WP_012677513.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
SEQ_RS11975	-	1724082..1724912 (-)	831	WP_230197368.1	GHKL domain-containing protein	-
SEQ_RS08310 (SEQ_1712)	comE/blpR	1725416..1726165 (-)	750	WP_012679946.1	response regulator transcription factor	Regulator
SEQ_RS08315 (SEQ_1713)	-	1726792..1726995 (-)	204	WP_012679947.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
SEQ_RS08320 (SEQ_1714)	-	1727012..1727269 (-)	258	WP_012679948.1	Blp family class II bacteriocin	-

Sequence

Protein

• Length: 718 a.a.
• Molecular weight: 80567.70 Da
• Isoelectric Point: 7.4894

>NTDB_id=33533 SEQ_RS08290 WP_012679943.1 1720204..1722360(+) (comA/nlmT) [Streptococcus equi subsp. equi 4047]
MTLFYKRTFVSQIDARDCGVAALASIARYYGSDYSLAHLRELAKTNKEGTTALGIVMAAKEMGFETRPIQADMTLFDMAD
VPYPLIVHVNKEGKLQHYYVVYKSKKDYLIIGDPDPMVKVTKMSKERFASEWTGVTICLAPKPNYKPHKDQKNGLLGFFP
LIFKQRTLIFYIVLASVLVTVINIAGSYYLQGILDEYIPNQLKSTLGIVSIGLIITYILQQLMSFSRDYLLTVLSQRLTI
DVILSYIRHIFELPMSFFATRRTGEVTSRFTDANSIIDALASTILSLFLDLSILAIVGSVLLVQNSRLFLLSLISIPVYT
IIICAFIKPFEQMNHDVMQSNAMLSSAIIEDINGIETIKSLTSEENRYQKIDSDFVDYLDKSFKLSKYTILQATLKQGAQ
LILNIIILWFGAQLVINGKISIGQLITFNTLLAYFTTPLENIINLQTKLQAAKVANNRLNEVYLVESEFKASQALYDLSL
LQGDIQFEAVSYRYGFGKDTLSDITLTIKQGAKVTLVGVSGSGKTTLAKMLVNFFEPYKGRITINQNDLKTIDKKNLRQY
INYLPQQAYVFNGSILENLTLGAKQGISQEDILNACEIADIRHDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTQA
PILVLDEATSGLDILTEKKIIDRLMNMTDKTIIFVAHRLSIAERTDQIVVLNQGQIIETGSHQELMKQGGFYYHLFSE

Nucleotide

• Length: 2157 bp

>NTDB_id=33533 SEQ_RS08290 WP_012679943.1 1720204..1722360(+) (comA/nlmT) [Streptococcus equi subsp. equi 4047]
ATGACACTCTTTTATAAAAGAACCTTTGTATCACAAATAGATGCCAGAGATTGTGGCGTAGCTGCTCTAGCCTCAATCGC
AAGGTATTATGGTTCAGATTATTCATTAGCTCATTTGAGAGAATTAGCAAAAACCAATAAGGAAGGGACAACAGCCCTCG
GTATTGTCATGGCTGCTAAGGAAATGGGATTTGAAACCAGACCCATTCAAGCGGATATGACCCTCTTTGACATGGCAGAC
GTGCCCTATCCATTGATCGTCCATGTCAATAAAGAAGGAAAGCTACAGCACTACTATGTGGTCTACAAATCTAAAAAAGA
CTATCTTATCATTGGTGATCCCGATCCAATGGTCAAGGTCACAAAAATGTCCAAGGAACGCTTTGCTTCAGAATGGACAG
GTGTCACCATATGTCTTGCTCCTAAGCCAAATTATAAACCACATAAAGACCAAAAAAATGGACTATTAGGCTTCTTTCCG
CTTATTTTTAAACAGCGAACCCTTATATTTTATATCGTGTTAGCTTCTGTCTTGGTAACGGTCATTAATATTGCTGGTTC
ATACTATCTCCAGGGGATTTTAGACGAGTATATTCCAAATCAGCTGAAATCTACCTTAGGGATTGTATCAATTGGTCTCA
TCATTACCTATATACTCCAGCAGCTAATGAGCTTTTCTAGAGATTATCTTTTAACTGTCCTTAGCCAACGTCTTACGATT
GATGTGATTCTGTCCTATATCCGCCATATTTTCGAATTGCCGATGTCCTTTTTTGCAACACGTCGAACAGGTGAGGTAAC
CTCGCGCTTTACAGATGCTAACTCTATTATTGATGCACTCGCTTCAACCATTTTATCCCTCTTTCTAGACCTCTCTATAT
TAGCTATTGTCGGAAGTGTTCTTTTGGTGCAAAATAGCAGGCTTTTTCTGCTATCTCTGATTTCTATCCCAGTATATACC
ATTATCATATGTGCCTTTATAAAGCCGTTTGAACAAATGAATCATGATGTGATGCAAAGCAATGCCATGCTAAGCTCTGC
TATTATCGAAGATATCAACGGGATCGAAACCATAAAATCACTAACCAGTGAAGAAAACCGTTACCAAAAAATTGACAGCG
ACTTTGTGGATTACCTTGATAAGTCTTTTAAGCTTAGTAAATATACCATCTTACAAGCCACACTTAAGCAAGGAGCGCAG
CTAATTCTGAATATCATCATTCTTTGGTTTGGGGCTCAACTGGTCATTAATGGTAAAATTTCAATCGGGCAATTAATTAC
CTTTAACACACTTCTTGCCTATTTTACAACCCCTTTAGAAAATATCATTAATCTTCAAACCAAGCTCCAAGCAGCTAAGG
TTGCCAATAATCGTCTCAATGAGGTCTATCTTGTAGAGTCCGAATTTAAAGCCTCGCAAGCCTTATACGATTTATCGCTC
TTACAGGGTGACATTCAGTTTGAAGCTGTTTCCTACAGGTATGGCTTTGGCAAGGATACATTATCAGATATTACATTAAC
CATTAAGCAGGGAGCAAAAGTAACCCTTGTTGGTGTCAGCGGCTCAGGAAAAACAACCCTAGCCAAGATGCTCGTCAATT
TCTTTGAACCTTATAAAGGACGTATAACCATCAACCAAAACGATCTCAAGACCATTGATAAAAAGAATCTTCGACAATAC
ATCAACTACCTTCCACAACAAGCCTATGTGTTTAATGGATCTATCTTAGAAAATCTAACCTTGGGAGCCAAGCAAGGCAT
CAGCCAGGAAGACATTCTTAACGCCTGTGAGATTGCTGACATTCGTCACGACATCGAGCAAATGCCAATGGGATACCAAA
CCGAGCTCTCTGATGGGGCTGGCTTATCTGGCGGACAAAAACAGAGAATTGCACTTGCTAGAGCATTACTAACCCAAGCT
CCTATACTAGTTCTTGATGAAGCAACCAGCGGACTTGACATACTGACAGAAAAGAAAATCATTGACCGTCTCATGAACAT
GACAGACAAAACGATTATTTTCGTTGCCCACCGGCTTAGTATCGCAGAGCGCACTGATCAGATTGTTGTTCTTAATCAAG
GGCAAATCATTGAAACAGGCAGCCACCAGGAATTAATGAAACAAGGTGGATTTTATTACCACCTATTTAGTGAATAA

Domains

Predicted by InterproScan.

• ABC transporter transmembrane region (ABC_membrane) (169-439)

• Peptidase C39 family (Peptidase_C39) (8-143)

• ABC transporter (ABC_tran) (501-650)

3D structure

• AlphaFold DB: C0MC58

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	70.851	99.861	0.708
comA	Streptococcus mitis SK321	67.602	99.304	0.671
comA	Streptococcus mitis NCTC 12261	67.321	99.304	0.669
comA	Streptococcus pneumoniae Rx1	66.9	99.304	0.664
comA	Streptococcus pneumoniae D39	66.9	99.304	0.664
comA	Streptococcus pneumoniae R6	66.9	99.304	0.664
comA	Streptococcus pneumoniae TIGR4	66.62	99.304	0.662
comA	Streptococcus gordonii str. Challis substr. CH1	65.358	99.304	0.649