Detailed information NTG0033360

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: SP70585_RS14245
• Genome accession: NC_012468
• Coordinates: 537237..537824 (-)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae 70585
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 532237..542824

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SP70585_RS02865 (SP70585_0584)	-	532701..534041 (+)	1341	WP_001017622.1	sensor histidine kinase	-
SP70585_RS02870 (SP70585_0585)	blpC	534083..534238 (-)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
SP70585_RS02875 (SP70585_0586)	-	534295..535656 (-)	1362	WP_001087624.1	bacteriocin secretion accessory protein	-
SP70585_RS02880 (SP70585_0587)	comA/nlmT	535667..537343 (-)	1677	WP_306293369.1	peptide cleavage/export ABC transporter	Regulator
SP70585_RS14245	comA/nlmT	537237..537824 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
SP70585_RS02890 (SP70585_0589)	blpI	538106..538303 (+)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
SP70585_RS02895 (SP70585_0590)	blpJ	538770..539039 (+)	270	WP_001093248.1	bacteriocin-like peptide BlpJ	-
SP70585_RS02900 (SP70585_0591)	blpU	539108..539338 (+)	231	WP_000379967.1	bacteriocin-like peptide BlpU	-
SP70585_RS02905 (SP70585_0592)	-	539341..539460 (+)	120	WP_000346298.1	PncF family bacteriocin immunity protein	-
SP70585_RS12200 (SP70585_0594)	-	539757..539921 (+)	165	WP_000727118.1	hypothetical protein	-
SP70585_RS02920 (SP70585_0595)	-	539918..540322 (+)	405	WP_000846944.1	hypothetical protein	-
SP70585_RS13100	-	540423..541237 (+)	815	Protein_564	IS5-like element IS1515 family transposase	-
SP70585_RS12205	-	541398..542204 (+)	807	Protein_565	IS5 family transposase	-
SP70585_RS02945 (SP70585_0600)	blpM	542354..542608 (+)	255	WP_000379879.1	two-peptide bacteriocin subunit BlpM	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=33360 SP70585_RS14245 WP_000205166.1 537237..537824(-) (comA/nlmT) [Streptococcus pneumoniae 70585]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=33360 SP70585_RS14245 WP_000205166.1 537237..537824(-) (comA/nlmT) [Streptococcus pneumoniae 70585]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497