Detailed information NTG0033294

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SP70585_RS02860
• Genome accession: NC_012468
• Coordinates: 531950..532687 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219147.1
• Uniprot ID: B1IA60
• Organism: Streptococcus pneumoniae 70585
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 526950..537687

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SP70585_RS12180 (SP70585_0576)	-	527881..528120 (-)	240	WP_001810235.1	hypothetical protein	-
SP70585_RS02830 (SP70585_0577)	-	528282..528569 (-)	288	WP_000777760.1	hypothetical protein	-
SP70585_RS02835 (SP70585_0578)	-	528579..528989 (-)	411	WP_001278301.1	HIT family protein	-
SP70585_RS02840 (SP70585_0579)	pptA	529057..529788 (+)	732	WP_000889919.1	ABC transporter ATP-binding protein	Regulator
SP70585_RS02845 (SP70585_0580)	-	529785..530834 (+)	1050	WP_000653767.1	ABC transporter permease	-
SP70585_RS02850 (SP70585_0581)	-	531002..531331 (-)	330	WP_000132572.1	hypothetical protein	-
SP70585_RS02855 (SP70585_0582)	-	531607..531945 (+)	339	WP_000876676.1	LytTR family DNA-binding domain-containing protein	-
SP70585_RS02860 (SP70585_0583)	comE/blpR	531950..532687 (+)	738	WP_001219147.1	response regulator transcription factor	Regulator
SP70585_RS02865 (SP70585_0584)	-	532701..534041 (+)	1341	WP_001017622.1	sensor histidine kinase	-
SP70585_RS02870 (SP70585_0585)	blpC	534083..534238 (-)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
SP70585_RS02875 (SP70585_0586)	-	534295..535656 (-)	1362	WP_001087624.1	bacteriocin secretion accessory protein	-
SP70585_RS02880 (SP70585_0587)	comA/nlmT	535667..537343 (-)	1677	WP_306293369.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28828.93 Da
• Isoelectric Point: 6.0454

>NTDB_id=33294 SP70585_RS02860 WP_001219147.1 531950..532687(+) (comE/blpR) [Streptococcus pneumoniae 70585]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSTEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=33294 SP70585_RS02860 WP_001219147.1 531950..532687(+) (comE/blpR) [Streptococcus pneumoniae 70585]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCCCAGCTCTTTTGAGGTATTTGGCAAGCCAGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGGCTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCCTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGACAGAGGAGTTTGAATCTCGAATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGTTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-241)

• Response regulator receiver domain (Response_reg) (3-122)

3D structure

• AlphaFold DB: B1IA60

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.882	96.735	0.424
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384
comE	Streptococcus infantis strain Atu-4	36.179	100	0.363