Detailed information NTG0033129

Bioinformatically predicted

Overview

• Name: comB
• Type: Regulator
• Locus tag: SPJ_RS00350
• Genome accession: NC_012466
• Coordinates: 54184..55533 (+)
• Length: 449 a.a.
• NCBI ID: WP_000801625.1
• Uniprot ID: C1C9U7
• Organism: Streptococcus pneumoniae JJA
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 49184..60533

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPJ_RS11360	-	50091..50573 (+)	483	WP_001232094.1	stage II sporulation protein M	-
SPJ_RS00330 (SPJ_0071)	-	50570..51166 (+)	597	WP_000687787.1	ATP-binding cassette domain-containing protein	-
SPJ_RS00335 (SPJ_0072)	-	51147..51638 (+)	492	WP_000671990.1	hypothetical protein	-
SPJ_RS00345 (SPJ_0073)	comA	52018..54171 (+)	2154	WP_000668291.1	peptide cleavage/export ABC transporter ComA	Regulator
SPJ_RS00350 (SPJ_0074)	comB	54184..55533 (+)	1350	WP_000801625.1	competence pheromone export protein ComB	Regulator
SPJ_RS00355 (SPJ_0075)	purC	55703..56410 (+)	708	WP_000043300.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
SPJ_RS13625 (SPJ_0076)	-	56421..56555 (+)	135	WP_000429437.1	hypothetical protein	-
SPJ_RS00365 (SPJ_0077)	-	56612..60337 (+)	3726	WP_000361215.1	phosphoribosylformylglycinamidine synthase	-

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 49583.43 Da
• Isoelectric Point: 5.3895

>NTDB_id=33129 SPJ_RS00350 WP_000801625.1 54184..55533(+) (comB) [Streptococcus pneumoniae JJA]
MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEMSLSTRATVEPSRILANIQSTSNNRILVNHLEENKL
VKKGDLLVQYQEGAEGVQAESYASQLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQN
ETIASQNAAASQTQSEIGNLISQTEAKIRDYQTAKSAIETGASLAGQNLAYSLYQSYKSQGEENPQTKVQAVAQVEAQIS
QLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKVGQELTLLAQKILEAESGKKVQGNLLDKGKITASEDGVLH
LNPETSDSSMVAEGALLAQLYPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTEK
GNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE

Nucleotide

• Length: 1350 bp

>NTDB_id=33129 SPJ_RS00350 WP_000801625.1 54184..55533(+) (comB) [Streptococcus pneumoniae JJA]
ATGAAACCAGAATTTTTAGAAAGTGCGGAGTTTTATAATCGTCGTTACCATAATTTTTCCAGTAGTGTGATTGTACCCAT
GGCCCTTCTGCTCGTGTTTTTACTTGGCTTTGCAACTGTTGCAGAAAAGGAGATGAGTTTGTCCACTAGAGCTACTGTCG
AACCTAGTCGTATCCTTGCAAATATCCAGTCAACTAGCAACAATCGTATTCTTGTCAATCATTTGGAAGAAAATAAGCTG
GTTAAGAAGGGGGATCTTTTGGTTCAATACCAAGAAGGGGCAGAGGGTGTCCAAGCGGAGTCCTATGCCAGTCAGTTGGA
CATGCTAAAGGATCAAAAAAAGCAATTGGAGTATCTGCAAAAGAGCCTGCAAGAAGGGGAGAACCACTTTCCAGAGGAGG
ATAAGTTTGGCTACCAAGCCACCTTTCGCGACTACATCAGTCAAGCAGGCAGTCTTAGGGCTAGTACATCGCAACAAAAT
GAGACCATCGCGTCCCAGAATGCAGCAGCTAGCCAAACCCAATCCGAAATCGGCAACCTCATCAGTCAAACAGAGGCTAA
AATTCGCGATTACCAGACAGCTAAGTCAGCTATTGAAACAGGTGCTTCCTTGGCCGGTCAGAATCTAGCCTACTCTCTTT
ACCAGTCCTACAAGTCTCAGGGCGAGGAAAATCCCCAAACTAAGGTTCAGGCAGTTGCACAGGTTGAAGCACAGATTTCT
CAGTTAGAATCTAGTCTTGCTACTTACCGTGTCCAGTATGCAGGTTCAGGTACCCAGCAAGCCTATGCGTCAGGGTTAAG
CAGTCAATTGGAATCCCTTAAATCCCAACACTTGGCAAAGGTTGGTCAGGAATTGACCCTTCTAGCCCAGAAAATCTTGG
AGGCAGAGTCAGGTAAGAAGGTACAGGGAAATCTTTTAGACAAGGGGAAAATTACGGCAAGTGAGGATGGGGTGCTTCAT
CTTAATCCTGAGACCAGTGATTCTAGCATGGTTGCAGAAGGTGCCCTACTAGCCCAACTTTATCCATCTTTGGAAAGAGA
AGGGAAAGCCAAACTCACAGCCTATCTAAGTTCAAAAGATGTAGCAAGAATCAAGGTCGGTGATTCTGTTCGCTATACTA
CGACTCATGATGCCGGGAATCAACTTTTTCTAGATTCTACTATTACAAGTATTGATGCGACAGCTACTAAGACTGAGAAA
GGGAATTTCTTTAAAATCGAGGCGGAGACTAATCTAACTTCGGAGCAGGCTGAAAAACTTAGGTACGGGGTGGAAGGCCG
CTTGCAGATGATTACGGGCAAGAAAAGTTATCTACGTTATTATTTGGATCAATTTTTGAACAAAGAGTAA

Domains

No domain identified.

3D structure

• AlphaFold DB: C1C9U7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comB	Streptococcus pneumoniae TIGR4	99.332	100	0.993
comB	Streptococcus pneumoniae Rx1	99.109	100	0.991
comB	Streptococcus pneumoniae D39	99.109	100	0.991
comB	Streptococcus pneumoniae R6	99.109	100	0.991
comB	Streptococcus mitis SK321	94.878	100	0.949
comB	Streptococcus mitis NCTC 12261	94.432	100	0.944
comB	Streptococcus gordonii str. Challis substr. CH1	55.333	100	0.555