Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   SPJ_RS00345 Genome accession   NC_012466
Coordinates   52018..54171 (+) Length   717 a.a.
NCBI ID   WP_000668291.1    Uniprot ID   A0A0T8TNJ6
Organism   Streptococcus pneumoniae JJA     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 47018..59171
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPJ_RS00310 (SPJ_0067) - 47219..48112 (+) 894 WP_000343888.1 XRE family transcriptional regulator -
  SPJ_RS00315 (SPJ_0068) - 48655..48951 (+) 297 WP_000837726.1 uberolysin/carnocyclin family circular bacteriocin -
  SPJ_RS00320 (SPJ_0069) - 48958..50094 (+) 1137 WP_000698828.1 hypothetical protein -
  SPJ_RS11360 - 50091..50573 (+) 483 WP_001232094.1 stage II sporulation protein M -
  SPJ_RS00330 (SPJ_0071) - 50570..51166 (+) 597 WP_000687787.1 ATP-binding cassette domain-containing protein -
  SPJ_RS00335 (SPJ_0072) - 51147..51638 (+) 492 WP_000671990.1 hypothetical protein -
  SPJ_RS00345 (SPJ_0073) comA 52018..54171 (+) 2154 WP_000668291.1 peptide cleavage/export ABC transporter ComA Regulator
  SPJ_RS00350 (SPJ_0074) comB 54184..55533 (+) 1350 WP_000801625.1 competence pheromone export protein ComB Regulator
  SPJ_RS00355 (SPJ_0075) purC 55703..56410 (+) 708 WP_000043300.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  SPJ_RS13625 (SPJ_0076) - 56421..56555 (+) 135 WP_000429437.1 hypothetical protein -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80368.41 Da        Isoelectric Point: 6.3368

>NTDB_id=33128 SPJ_RS00345 WP_000668291.1 52018..54171(+) (comA) [Streptococcus pneumoniae JJA]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPHKEQKNGLLSFIPI
LVKQRGLIANIVLATLLVTVINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGDMTFKQVHYKYGYGRDVLSDINLTVPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=33128 SPJ_RS00345 WP_000668291.1 52018..54171(+) (comA) [Streptococcus pneumoniae JJA]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAAGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTATGGTAGTTATTATTTTTTGGCTCACTTGCGAGAATTGGCTAAGACGACCATGGATGGGACGACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGTTTTGAGACGCGAGCCATTAAGGCGGATATGACGCTTTTTGACTTGCCGGATTTG
ACTTTTCCTTTTGTTGCCCATGTGCTTAAGGAAGGGAAATTGCTCCACTACTATGTGGTGACTGGGCAGGATAAGGATAG
CATTCATATTGCCGATCCAGATCCCGGGGTGAAGTTGACTAAACTGCCACGTGAGCGTTTTGAGGAAGAATGGACAGGAG
TGACTCTTTTTATGGCGCCTAGTCCAGACTATAAGCCTCATAAGGAACAAAAAAATGGTCTGCTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCCAATATCGTTTTGGCAACACTCTTGGTAACCGTGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACACTAGGGATTATTTCTATTGGGCTAGTCA
TCGTCTACATCCTCCAGCAAATCTTGTCTTACGCTCAGGAGTATCTCTTGCTTGTTTTGGGGCAACGCTTGTCGATTGAC
GTGATTTTGTCCTATATCAAGCATGTTTTTCACCTCCCTATGTCCTTCTTTGCGACACGCAGGACAGGGGAGATCGTGTC
TCGTTTTACAGATGCTAACAGTATTATCGATGCGCTGGCTTCGACCATTCTTTCGATTTTCCTAGATGTGTCAACAGTTG
TCATTATTTCCCTTGTTTTATTTTCACAAAATACCAATCTCTTTTTCATGACTTTATTGGCGCTTCCTATCTACACAGTG
ATTATCTTTGCCTTTATGAAGCCGTTTGAAAAGATGAATCGGGACACCATGGAAGCCAATGCGGTTCTGTCTTCTTCTAT
CATTGAGGACATCAACGGTATTGAGACTATCAAGTCCTTGACCAGTGAAAGTCAGCGTTACCAAAAAATTGACAAGGAAT
TTGTGGATTATCTGAAGAAATCCTTTACCTATAGTCGAGCAGAGAGTCAGCAAAAGGCTCTGAAAAAGGTTGCCCATCTC
TTGCTTAATGTCGGCATTCTCTGGATGGGGGCTGTTCTGGTCATGGATGGCAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTGCTGGTTTACTTTACCAATCCTTTGGAAAATATCATCAATCTGCAAACCAAGCTTCAGACAGCGCAGGTTG
CCAATAACCGTCTAAATGAAGTGTATCTAGTAGCTTCTGAGTTTGAGGAGAAGAAAACAGTTGAGGATTTGAGCTTGATG
AAGGGAGATATGACCTTCAAGCAGGTTCATTACAAGTATGGCTATGGTCGAGACGTCTTGTCGGATATCAATTTAACCGT
TCCCCAAGGGTCTAAGGTGGCTTTTGTGGGGATTTCAGGGTCAGGTAAGACGACTTTGGCCAAGATGATGGTTAATTTTT
ACGACCCAAGTCAAGGGGAGATTAGTCTGGGTGGTGTCAATCTCAATCAGATTGATAAAAAAGCCCTGCGCCAGTACATC
AACTATCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTGGAGAATCTTCTTTTGGGAGCCAAGGAGGGGACGAC
ACAGGAAGATATCTTACGGGCGGTCGAATTGGCAGAGATTCGAGAGGATATCGAGCGCATGCCACTGAATTACCAGACAG
AATTGACTTCGGATGGGGCAGGGATTTCAGGTGGTCAACGTCAGAGAATCGCTTTGGCGCGTGCTCTCTTGACAGATGCG
CCGGTCTTGATTTTGGATGAGGCGACTAGCAGTTTGGATATTTTGACAGAGAAGCGGATTGTCGATAATCTCATGGCTTT
GGACAAGACCTTGATTTTCATTGCTCACCGCTTGACTATTGCTGAGCGGACAGAGAAGGTAGTTGTCTTGGATCAGGGCA
AGATTGTCGAAGAAGGAAAGCATGCTGATTTGCTTGCACAGGGTGGCTTTTACGCCCATTTGGTCAATAGCTAG

Domains

Predicted by InterproScan.

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter (ABC_tran)

(500-650)

ABC transporter transmembrane region (ABC_membrane)

(170-438)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0T8TNJ6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus pneumoniae Rx1

99.861

100

0.999
  comA Streptococcus pneumoniae D39

99.861

100

0.999
  comA Streptococcus pneumoniae R6

99.861

100

0.999
  comA Streptococcus pneumoniae TIGR4

99.442

100

0.994
  comA Streptococcus mitis SK321

98.605

100

0.986
  comA Streptococcus mitis NCTC 12261

98.605

100

0.986
  comA Streptococcus gordonii str. Challis substr. CH1

80.753

100

0.808
  comA/nlmT Streptococcus mutans UA159

64.854

100

0.649

Multiple sequence alignment