Detailed information NTG0032681

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: SPN23F_RS05695
• Genome accession: NC_011900
• Coordinates: 1096416..1097120 (-)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae ATCC 700669
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1091416..1102120

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPN23F_RS05665 (SPN23F11170)	-	1091620..1092606 (+)	987	WP_000204727.1	L-lactate dehydrogenase	-
SPN23F_RS05670 (SPN23F11180)	-	1092854..1093627 (-)	774	WP_000731139.1	potassium channel family protein	-
SPN23F_RS05675 (SPN23F11190)	-	1093674..1093928 (-)	255	WP_001809704.1	type II toxin-antitoxin system RelE family toxin	-
SPN23F_RS05680 (SPN23F11200)	relB	1093930..1094172 (-)	243	WP_000208080.1	type II toxin-antitoxin system RelB family antitoxin	-
SPN23F_RS05685 (SPN23F11210)	vicX	1094263..1095072 (-)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
SPN23F_RS05690 (SPN23F11220)	micB	1095074..1096423 (-)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
SPN23F_RS05695 (SPN23F11230)	micA	1096416..1097120 (-)	705	WP_000722076.1	response regulator YycF	Regulator
SPN23F_RS05700 (SPN23F11240)	mutY	1097175..1098350 (-)	1176	WP_000886152.1	A/G-specific adenine glycosylase	-
SPN23F_RS14115	-	1098447..1098572 (+)	126	WP_001818232.1	hypothetical protein	-
SPN23F_RS05705 (SPN23F11250)	-	1098678..1100348 (-)	1671	WP_000845292.1	formate--tetrahydrofolate ligase	-
SPN23F_RS05710 (SPN23F11260)	coaB	1100578..1101267 (+)	690	WP_000699492.1	phosphopantothenate--cysteine ligase	-
SPN23F_RS05715 (SPN23F11270)	coaC	1101279..1101830 (+)	552	WP_001284128.1	phosphopantothenoylcysteine decarboxylase	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=32681 SPN23F_RS05695 WP_000722076.1 1096416..1097120(-) (micA) [Streptococcus pneumoniae ATCC 700669]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=32681 SPN23F_RS05695 WP_000722076.1 1096416..1097120(-) (micA) [Streptococcus pneumoniae ATCC 700669]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTATGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACACGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38