Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   EGX72_RS06950 Genome accession   NZ_CP033809
Coordinates   1287933..1288613 (+) Length   226 a.a.
NCBI ID   WP_000590620.1    Uniprot ID   A0AAV3JNX7
Organism   Streptococcus sp. FDAARGOS_521     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1282933..1293613
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EGX72_RS06935 (EGX72_06930) pstB 1283631..1284389 (+) 759 WP_000193363.1 phosphate ABC transporter ATP-binding protein PstB -
  EGX72_RS06940 (EGX72_06935) phoU 1284423..1285076 (+) 654 WP_000946330.1 phosphate signaling complex protein PhoU -
  EGX72_RS06945 (EGX72_06940) - 1285222..1287771 (+) 2550 WP_123957747.1 M1 family metallopeptidase -
  EGX72_RS06950 (EGX72_06945) ciaR 1287933..1288613 (+) 681 WP_000590620.1 response regulator transcription factor Regulator
  EGX72_RS06955 (EGX72_06950) ciaH 1288597..1289910 (+) 1314 WP_000042580.1 cell wall metabolism sensor histidine kinase WalK Regulator
  EGX72_RS06960 (EGX72_06955) - 1289999..1290331 (+) 333 WP_000402075.1 putative DNA-binding protein -
  EGX72_RS06965 (EGX72_06960) ffh 1290349..1291914 (+) 1566 WP_000863589.1 signal recognition particle protein -
  EGX72_RS06970 (EGX72_06965) - 1291981..1292667 (+) 687 WP_000280308.1 SatD family protein -
  EGX72_RS06975 (EGX72_06970) - 1292657..1293430 (+) 774 WP_000622398.1 DUF3307 domain-containing protein -

Sequence

Protein


Download         Length: 226 a.a.        Molecular weight: 25852.63 Da        Isoelectric Point: 4.2507

>NTDB_id=325876 EGX72_RS06950 WP_000590620.1 1287933..1288613(+) (ciaR) [Streptococcus sp. FDAARGOS_521]
MIKILLIEDDLSLSNSVFDFLDDFADVMQIFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESIDDKGQGFDLGADDYLTKPFYLEELKMRIQALLKRSGKFNDNSLIYGDIRVDMSTNSTFVNQTEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKVRKKLKGTLFSENLQTLRSVGYILKHVETD

Nucleotide


Download         Length: 681 bp        

>NTDB_id=325876 EGX72_RS06950 WP_000590620.1 1287933..1288613(+) (ciaR) [Streptococcus sp. FDAARGOS_521]
ATGATAAAAATTTTATTAATTGAAGATGACTTGAGTCTTTCCAATTCCGTTTTTGATTTCCTTGATGACTTTGCCGATGT
CATGCAAATTTTTGATGGAGAAGAGGGTCTTTACGAAGCCGAAAGTGGAGTCTATGATCTGATTCTTCTAGATCTCATGT
TACCTGAAAAAAACGGCTTCCAAGTGTTGAAAGAGCTACGTGAAAAAGGTATTACAACCCCTGTATTAATAATGACCGCT
AAAGAAAGCATTGATGATAAGGGACAAGGTTTCGACTTAGGTGCTGATGATTATCTAACAAAACCTTTTTACCTAGAAGA
ACTAAAAATGCGAATTCAGGCTCTTTTAAAGCGTTCTGGAAAATTTAATGATAACAGCCTAATTTATGGTGATATTCGCG
TAGACATGTCTACTAACTCAACCTTTGTTAATCAAACAGAAGTTGAGCTCTTAGGTAAAGAGTTTGATCTTTTAGTCTAT
TTCCTTCAAAATCAAAATGTTATCTTACCGAAATCTCAAATCTTTGATCGTATTTGGGGATTTGATAGTGATACAACGAT
TTCAGTTGTAGAAGTCTATGTCTCTAAGGTTCGGAAAAAATTAAAAGGAACACTTTTTTCAGAAAACCTTCAAACTTTGC
GTAGTGTAGGATATATTTTAAAGCATGTCGAAACCGATTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae TIGR4

88.393

99.115

0.876
  ciaR Streptococcus pneumoniae D39

88.393

99.115

0.876
  ciaR Streptococcus pneumoniae R6

88.393

99.115

0.876
  ciaR Streptococcus pneumoniae Rx1

88.393

99.115

0.876
  ciaR Streptococcus mutans UA159

88.688

97.788

0.867
  vicR Streptococcus mutans UA159

35.193

100

0.363
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.607

99.115

0.363

Multiple sequence alignment