Detailed information NTG0323132

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: EB816_RS04770
• Genome accession: NZ_CP033337
• Coordinates: 911599..912435 (+)
• Length: 278 a.a.
• NCBI ID: WP_023611998.1
• Uniprot ID: A0A5S4TFX7
• Organism: Streptococcus pyogenes strain TSPY453
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 906599..917435

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EB816_RS04740 (EB816_04740)	-	907153..907521 (+)	369	WP_010922310.1	hypothetical protein	-
EB816_RS04745 (EB816_04745)	-	907571..908482 (-)	912	WP_023612012.1	diacylglycerol kinase family protein	-
EB816_RS04750 (EB816_04750)	-	908599..909249 (-)	651	WP_002984629.1	hemolysin III family protein	-
EB816_RS04755 (EB816_04755)	-	909246..909686 (-)	441	WP_011017769.1	DUF1836 domain-containing protein	-
EB816_RS04760 (EB816_04760)	ylqF	909905..910753 (+)	849	WP_023611994.1	ribosome biogenesis GTPase YlqF	-
EB816_RS04765 (EB816_04765)	-	910743..911534 (+)	792	WP_023612045.1	ribonuclease HII	-
EB816_RS04770 (EB816_04770)	dprA	911599..912435 (+)	837	WP_023611998.1	DNA-processing protein DprA	Machinery gene
EB816_RS04775 (EB816_04775)	topA	912543..914672 (+)	2130	WP_050336211.1	type I DNA topoisomerase	-
EB816_RS10160	-	914747..915631 (-)	885	Protein_871	LysR family transcriptional regulator	-
EB816_RS04790 (EB816_04790)	-	915644..916210 (+)	567	Protein_872	PTS sugar transporter subunit IIC	-
EB816_RS04795 (EB816_04795)	-	916225..917217 (+)	993	WP_023612447.1	D-lactate dehydrogenase	-

Sequence

Protein

• Length: 278 a.a.
• Molecular weight: 30958.92 Da
• Isoelectric Point: 8.8230

>NTDB_id=323132 EB816_RS04770 WP_023611998.1 911599..912435(+) (dprA) [Streptococcus pyogenes strain TSPY453]
MNHFELYKLKKAGLTNKNILNILDYQEHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPGEEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGAACVTSGMDILSEY

Nucleotide

• Length: 837 bp

>NTDB_id=323132 EB816_RS04770 WP_023611998.1 911599..912435(+) (dprA) [Streptococcus pyogenes strain TSPY453]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCTGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTCGGCTCCAGACGCTCAAGCGATACTGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAATCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACTATC
GCTATTATTGGAACAGGATTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAGGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAGCATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (68-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: A0A5S4TFX7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	67.626	100	0.676
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	60.791	100	0.608
dprA/cilB/dalA	Streptococcus pneumoniae D39	60.791	100	0.608
dprA/cilB/dalA	Streptococcus pneumoniae R6	60.791	100	0.608
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	60.791	100	0.608
dprA/cilB/dalA	Streptococcus mitis SK321	60.791	100	0.608
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	60.432	100	0.604
dprA	Lactococcus lactis subsp. cremoris KW2	57.554	100	0.576
dprA	Legionella pneumophila strain ERS1305867	42.857	85.612	0.367