Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   EB816_RS01165 Genome accession   NZ_CP033337
Coordinates   200954..203104 (+) Length   716 a.a.
NCBI ID   WP_023612228.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain TSPY453     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 195954..208104
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EB816_RS01140 (EB816_01140) - 196264..196641 (-) 378 WP_023612231.1 hypothetical protein -
  EB816_RS01145 (EB816_01145) - 196834..197166 (+) 333 WP_023612241.1 LytTR family DNA-binding domain-containing protein -
  EB816_RS01150 (EB816_01150) comE/blpR 197175..197912 (+) 738 WP_023612237.1 response regulator transcription factor Regulator
  EB816_RS01155 (EB816_01155) - 197912..199255 (+) 1344 WP_032465581.1 GHKL domain-containing protein -
  EB816_RS10105 - 199326..199469 (-) 144 WP_023612234.1 hypothetical protein -
  EB816_RS10425 - 200244..200375 (+) 132 WP_023612236.1 hypothetical protein -
  EB816_RS01165 (EB816_01165) comA 200954..203104 (+) 2151 WP_023612228.1 peptide cleavage/export ABC transporter ComA Regulator
  EB816_RS01170 (EB816_01170) - 203113..204474 (+) 1362 WP_023612230.1 bacteriocin secretion accessory protein -
  EB816_RS01175 (EB816_01175) - 204616..204789 (+) 174 WP_023612227.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  EB816_RS01180 (EB816_01180) - 204808..204975 (+) 168 WP_023612226.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  EB816_RS01190 (EB816_01190) - 205612..206961 (+) 1350 WP_011888573.1 glucose-6-phosphate isomerase -

Sequence

Protein


Download         Length: 716 a.a.        Molecular weight: 80446.43 Da        Isoelectric Point: 7.1134

>NTDB_id=323111 EB816_RS01165 WP_023612228.1 200954..203104(+) (comA) [Streptococcus pyogenes strain TSPY453]
MAFRKKHYRPQVDTRDCGVASLAMVFGYYGSYYSLATLRELAKTTQEGTTAFGLVKVAEGEGFETRAIRADMTLFDEDII
YPFIAHVLKNGNLMHYYVVTGCDKKTIHIADPDPTVKMIKMPRERFEKEWTGVSIFIAPAPSYRIHKEQKDNLLSFLPIL
SRQKGLIVNIVVATLLVTLINIVGSYYLQSIIDTYIPEQVKNTLSIVSVGLVIVYILQQLISYAQEYLLLVLGQRLSIDV
ILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSVIIIVSIVLFSQNINLFFISLLALPIYTVI
ILSFVKPFERMNRETMEANATLSSSIIEDINGIETIKSLTSERQRYQKIDKEFVDYLKKSFAYGKAESTQKTLKKLAQLL
LNVAVLWMGANLVMDNKMSLGQLITYNSLLAYFTNPLENLINLQTKLQTAKVANNRLNEVYLVKSEFEEIKTVNDLSNFK
GHLSFKNVTYRYGYGKDVLTDIDLSIKPGSKVSFVGISGSGKTTLAKMLVNFFSPTKGEILLDDVNLEDIDKESLRRYIN
YLPQQPYVFNGTILDNLLLGAKEGTTQEDILKAVQIAEIKSDIEAMPLNYQTELTSDGSGISGGQRQRIALARALLTGSP
ILILDEATSSLDVLTEKKIIDNLMALDKTLIFIAHRLTISERTEHIVVLDKGNIIEEGNHTELLAKQGFYAHLVNS

Nucleotide


Download         Length: 2151 bp        

>NTDB_id=323111 EB816_RS01165 WP_023612228.1 200954..203104(+) (comA) [Streptococcus pyogenes strain TSPY453]
ATGGCATTTCGGAAAAAACATTACCGACCACAGGTAGATACAAGAGACTGCGGTGTTGCCTCTTTGGCTATGGTCTTTGG
CTACTATGGGTCTTACTATTCGCTAGCTACACTTCGAGAGCTCGCAAAGACTACTCAGGAAGGAACAACAGCTTTTGGAT
TGGTCAAAGTTGCCGAAGGGGAGGGGTTTGAAACTCGTGCCATTAGGGCCGATATGACCTTATTTGACGAGGATATTATC
TATCCTTTTATCGCCCACGTGCTTAAGAATGGCAATCTCATGCACTATTATGTGGTCACAGGTTGTGATAAAAAGACCAT
TCACATCGCAGACCCAGATCCTACGGTTAAAATGATTAAAATGCCTCGGGAGCGTTTTGAAAAGGAGTGGACAGGAGTTT
CTATTTTTATTGCTCCTGCGCCCAGTTACAGAATCCATAAGGAACAAAAGGACAATCTACTTTCCTTCTTGCCAATTTTA
TCTCGTCAAAAAGGCTTGATTGTCAATATTGTTGTAGCTACCTTATTGGTCACCTTAATTAATATTGTTGGCTCATACTA
CTTGCAGTCTATTATTGATACCTATATTCCAGAGCAGGTAAAAAACACATTAAGTATTGTTTCTGTAGGACTTGTAATTG
TTTATATCTTGCAGCAATTGATTTCTTATGCCCAGGAGTATTTACTTTTAGTTCTTGGTCAGAGGCTCTCTATTGACGTT
ATTCTATCCTATATTAAGCATGTTTTCCATCTTCCAATGTCATTCTTTGCGACAAGAAGAACAGGGGAAATAGTATCACG
TTTTACAGATGCAAATTCTATTATTGATGCTTTGGCAAGCACAATTTTATCTATTTTCTTAGATGTCTCAGTCATCATTA
TTGTATCGATAGTGTTATTCTCTCAAAACATTAACCTCTTTTTCATTAGTTTATTAGCTTTACCAATTTATACTGTGATT
ATTCTTTCGTTCGTGAAACCTTTTGAGCGTATGAATCGGGAAACTATGGAAGCTAATGCTACCCTATCTTCTTCAATTAT
TGAAGATATCAATGGTATTGAGACCATTAAATCATTAACAAGTGAAAGGCAACGTTACCAAAAAATTGATAAAGAGTTTG
TTGATTACTTGAAAAAATCTTTTGCTTATGGTAAAGCTGAAAGTACTCAAAAAACATTGAAAAAATTAGCTCAATTGTTA
CTTAATGTAGCCGTTCTTTGGATGGGAGCTAATCTAGTTATGGATAATAAGATGTCACTTGGTCAATTGATTACTTATAA
CTCTTTACTAGCATACTTCACAAACCCATTAGAAAATCTTATAAACCTTCAGACAAAATTACAAACAGCTAAAGTTGCCA
ATAATCGTTTAAATGAAGTGTATCTTGTGAAATCAGAATTTGAGGAGATAAAAACAGTTAATGATTTAAGCAATTTTAAG
GGTCATTTATCGTTTAAAAATGTTACATATCGCTATGGATACGGAAAAGATGTCCTAACAGATATTGATTTAAGTATAAA
GCCTGGTAGTAAAGTATCTTTTGTTGGGATATCAGGCTCGGGAAAAACAACCTTGGCTAAAATGTTAGTCAATTTCTTTA
GTCCTACTAAGGGAGAGATATTATTGGATGATGTGAACTTAGAAGATATTGATAAAGAAAGTCTACGTCGTTATATCAAC
TATCTCCCACAACAGCCATATGTATTTAATGGAACAATTTTGGATAATCTTTTATTAGGTGCTAAAGAAGGAACAACCCA
AGAAGATATTTTAAAAGCTGTTCAGATTGCTGAAATTAAGTCAGATATCGAAGCTATGCCACTCAATTATCAAACAGAAT
TGACATCGGATGGTTCAGGTATATCAGGCGGGCAACGTCAACGTATTGCTTTGGCACGTGCTTTATTGACAGGTTCTCCA
ATTCTTATTCTAGATGAGGCAACAAGCAGCTTAGATGTTTTAACAGAAAAGAAAATTATTGATAATCTCATGGCGCTAGA
TAAAACATTGATATTCATTGCTCATAGACTAACGATTTCAGAGAGAACTGAACATATCGTGGTACTGGATAAAGGTAATA
TTATTGAAGAAGGGAACCACACGGAGTTGTTAGCTAAACAAGGTTTCTATGCCCATCTTGTCAATAGTTAG

Domains

Predicted by InterproScan.

ABC transporter transmembrane region (ABC_membrane)

(169-437)

Peptidase C39 family (Peptidase_C39)

(6-141)

ABC transporter (ABC_tran)

(499-649)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus mitis NCTC 12261

80.614

100

0.807
  comA Streptococcus mitis SK321

80.056

100

0.802
  comA Streptococcus pneumoniae Rx1

79.916

100

0.8
  comA Streptococcus pneumoniae D39

79.916

100

0.8
  comA Streptococcus pneumoniae R6

79.916

100

0.8
  comA Streptococcus pneumoniae TIGR4

79.637

100

0.797
  comA Streptococcus gordonii str. Challis substr. CH1

75.314

100

0.754
  comA/nlmT Streptococcus mutans UA159

63.04

100

0.631

Multiple sequence alignment