Detailed information NTG0323047

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: EB817_RS00335
• Genome accession: NZ_CP033336
• Coordinates: 53176..54087 (+)
• Length: 303 a.a.
• NCBI ID: WP_011888526.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain TSPY165
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48176..59087

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EB817_RS00315 (EB817_00315)	purE	48460..48951 (+)	492	WP_032463145.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
EB817_RS00320 (EB817_00320)	purK	48938..50011 (+)	1074	WP_164976410.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
EB817_RS00325 (EB817_00325)	-	50038..51735 (+)	1698	WP_129304353.1	AIPR family protein	-
EB817_RS00330 (EB817_00330)	purB	51753..53045 (+)	1293	WP_129304355.1	adenylosuccinate lyase	-
EB817_RS00335 (EB817_00335)	comR	53176..54087 (+)	912	WP_011888526.1	XRE family transcriptional regulator	Regulator
EB817_RS09375	comS	54178..54276 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
EB817_RS00340 (EB817_00340)	ruvB	54307..55305 (+)	999	WP_014407198.1	Holliday junction branch migration DNA helicase RuvB	-
EB817_RS00345 (EB817_00345)	-	55443..55880 (+)	438	WP_002994668.1	low molecular weight phosphotyrosine protein phosphatase	-
EB817_RS00350 (EB817_00350)	-	55903..56304 (+)	402	WP_012560369.1	MORN repeat-containing protein	-
EB817_RS00355 (EB817_00355)	-	56301..58076 (+)	1776	WP_129304357.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35915.59 Da
• Isoelectric Point: 4.9349

>NTDB_id=323047 EB817_RS00335 WP_011888526.1 53176..54087(+) (comR) [Streptococcus pyogenes strain TSPY165]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDVQFYEEITESMLKQHNNLSLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=323047 EB817_RS00335 WP_011888526.1 53176..54087(+) (comR) [Streptococcus pyogenes strain TSPY165]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTCTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGTACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTATCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTCCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.67	100	0.997
comR	Streptococcus pyogenes MGAS8232	58.472	99.34	0.581
comR	Streptococcus mutans UA159	47.157	98.68	0.465
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.374	98.02	0.366
comR	Streptococcus suis 05ZYH33	37.374	98.02	0.366