Detailed information NTG0317222

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: D7D53_RS08850
• Genome accession: NZ_CP032621
• Coordinates: 1756401..1758554 (-)
• Length: 717 a.a.
• NCBI ID: WP_120770736.1
• Uniprot ID: A0A387B2A8
• Organism: Streptococcus gwangjuensis strain KCOM 1679 (=ChDC B345)
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1751401..1763554

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
D7D53_RS10320 (D7D53_08835)	-	1754016..1754159 (-)	144	WP_120770879.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
D7D53_RS08840 (D7D53_08840)	purC	1754161..1754868 (-)	708	WP_000043282.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
D7D53_RS08845 (D7D53_08845)	comB	1755039..1756388 (-)	1350	WP_120770735.1	competence pheromone export protein ComB	Regulator
D7D53_RS08850 (D7D53_08850)	comA	1756401..1758554 (-)	2154	WP_120770736.1	peptide cleavage/export ABC transporter ComA	Regulator
D7D53_RS08855 (D7D53_08855)	-	1758987..1759166 (-)	180	WP_050219186.1	hypothetical protein	-
D7D53_RS10250 (D7D53_08860)	-	1759247..1759450 (-)	204	WP_120770737.1	bacteriocin immunity protein	-
D7D53_RS08865 (D7D53_08865)	-	1759454..1759621 (-)	168	WP_001047583.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
D7D53_RS08875 (D7D53_08875)	-	1760117..1760296 (-)	180	WP_120770739.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
D7D53_RS08885 (D7D53_08885)	-	1760505..1760693 (-)	189	WP_120770741.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
D7D53_RS08890 (D7D53_08890)	-	1761137..1761373 (-)	237	WP_000136444.1	acyl carrier protein	-
D7D53_RS08895 (D7D53_08895)	plsX	1761379..1762371 (-)	993	WP_020900475.1	phosphate acyltransferase PlsX	-
D7D53_RS08900 (D7D53_08900)	recO	1762368..1763138 (-)	771	WP_120770742.1	DNA repair protein RecO	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80405.47 Da
• Isoelectric Point: 6.3886

>NTDB_id=317222 D7D53_RS08850 WP_120770736.1 1756401..1758554(-) (comA) [Streptococcus gwangjuensis strain KCOM 1679 (=ChDC B345)]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYSLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPRVKLTKLPRERFAEEWTGVTLFMAPSPDYKPHKDQKNSLLSFIPI
LVKQRGLIANIVLATLLVTLINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYIFQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLIASEFEEKKTVEDLSLM
KGDMTFKQVSYKYGYGRDVLSDINLTIPQGAKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILWAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS

Nucleotide

• Length: 2154 bp

>NTDB_id=317222 D7D53_RS08850 WP_120770736.1 1756401..1758554(-) (comA) [Streptococcus gwangjuensis strain KCOM 1679 (=ChDC B345)]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAAGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTATGGTAGTTATTATTCTTTGGCACACCTGCGAGAATTAGCCAAGACAACCATGGATGGGACAACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGCTTTGAGACACGGGCCATTAAGGCAGATATGACGCTCTTTGACTTGCCAGATTTG
ACTTTTCCTTTTGTTGCCCATGTGCTTAAGGAAGGGAAATTGCTCCACTACTATGTGGTGACTGGGCAGGATAAGGATAG
CATTCATATTGCCGATCCAGATCCTAGGGTGAAATTGACCAAACTGCCACGTGAGCGTTTTGCGGAAGAATGGACAGGGG
TGACTCTGTTTATGGCACCTAGTCCAGACTATAAGCCTCATAAGGATCAAAAGAATAGTCTGCTCTCTTTTATTCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCTAATATCGTTTTGGCGACACTCTTGGTAACCTTGATTAATATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACGCTGGGGATTATTTCTATTGGGCTGGTCA
TCGTCTATATCTTCCAGCAGATCTTGTCTTACGCTCAGGAGTATCTCTTGCTTGTTTTGGGGCAACGCTTGTCGATTGAT
GTAATTTTATCCTACATCAAGCACGTCTTTCACCTGCCTATGTCCTTTTTTGCGACACGCAGGACAGGGGAAATCGTCTC
TCGTTTTACAGATGCTAACAGTATCATCGATGCACTGGCTTCAACCATTCTTTCGATTTTCCTAGATGTGTCAACGGTTG
TCATTATTTCCCTTGTTTTATTTTCACAAAATACCAATCTCTTTTTTATGACTTTACTGGCGCTTCCTATCTACACAGTG
ATTATCTTTGCCTTTATGAAGCCATTTGAAAAGATGAATCGAGACACCATGGAAGCCAATGCGGTTCTGTCTTCTTCTAT
CATCGAGGACATCAATGGTATTGAGACTATTAAGTCCTTGACCAGTGAGAGTCAGCGTTACCAAAAAATTGACAAGGAAT
TTGTGGATTATCTGAAAAAATCTTTTACCTATAGTCGGGCAGAGAGTCAGCAAAAGGCTCTGAAAAAAGTTGCCCATCTC
TTGCTCAATGTCGGCATTCTCTGGATGGGGGCTGTTCTGGTCATGGATGGCAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTGCTTGTTTATTTTACCAATCCTTTGGAAAATATCATCAATCTGCAAACCAAGCTTCAGACAGCGCAGGTTG
CCAATAACCGTCTGAATGAGGTTTATTTGATAGCTTCTGAGTTTGAGGAGAAGAAAACAGTTGAGGATCTGAGCTTGATG
AAGGGAGATATGACCTTCAAGCAGGTTTCCTACAAGTATGGCTATGGTCGAGACGTCTTGTCGGATATCAATTTGACCAT
TCCCCAAGGGGCTAAGGTGGCTTTTGTGGGGATTTCAGGGTCAGGTAAGACGACCTTGGCCAAGATGATGGTTAATTTTT
ACGACCCAAGTCAGGGAGAGATTAGTCTGGGTGGTGTTAATCTTAATCAGATTGATAAAAAAGCCCTGCGCCAGTACATC
AACTATCTACCTCAACAGCCCTATGTTTTTAACGGAACGATATTGGAGAATCTTCTCCTTGGAGCCAAGGAAGGGACGAC
TCAAGAGGATATCTTATGGGCGGTCGAATTGGCAGAGATTCGGGAGGACATTGAGCGCATGCCACTGAATTACCAGACAG
AGTTGACTTCAGATGGGGCAGGAATTTCAGGTGGTCAACGTCAGAGAATCGCTCTGGCGCGTGCTCTCTTGACAGATGCG
CCTGTCTTGATTTTAGATGAGGCAACTAGCAGTTTGGATATTTTGACAGAGAAGCGAATTGTTGATAATCTCATGGCTTT
AGACAAGACCTTGATTTTCATTGCTCACCGCTTGACCATTGCTGAGCGGACAGAGAAGGTTGTTGTCTTGGATCAGGGCA
AGATTGTCGAAGAAGGAAAGCATGCTGATTTGCTTGCACAAGGTGGCTTTTACGCCCATTTGGTGAATAGCTAG

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter (ABC_tran) (500-650)

• ABC transporter transmembrane region (ABC_membrane) (170-438)

3D structure

• AlphaFold DB: A0A387B2A8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	98.605	100	0.986
comA	Streptococcus mitis SK321	98.187	100	0.982
comA	Streptococcus pneumoniae Rx1	98.187	100	0.982
comA	Streptococcus pneumoniae D39	98.187	100	0.982
comA	Streptococcus pneumoniae R6	98.187	100	0.982
comA	Streptococcus pneumoniae TIGR4	98.047	100	0.98
comA	Streptococcus gordonii str. Challis substr. CH1	80.335	100	0.803
comA/nlmT	Streptococcus mutans UA159	64.854	100	0.649