Detailed information NTG0317182

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: D7D53_RS03255
• Genome accession: NZ_CP032621
• Coordinates: 652124..652798 (+)
• Length: 224 a.a.
• NCBI ID: WP_000590639.1
• Uniprot ID: A0A419RXM2
• Organism: Streptococcus gwangjuensis strain KCOM 1679 (=ChDC B345)
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 647124..657798

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
D7D53_RS03235 (D7D53_03235)	-	647238..647936 (+)	699	WP_120770104.1	3-oxoacyl-ACP reductase	-
D7D53_RS10170	-	647957..648085 (+)	129	Protein_616	NUDIX hydrolase	-
D7D53_RS03240 (D7D53_03240)	-	648063..648947 (+)	885	WP_120770105.1	putative PEP-binding protein	-
D7D53_RS03245 (D7D53_03245)	-	648907..649347 (+)	441	WP_120770106.1	ASCH domain-containing protein	-
D7D53_RS03250 (D7D53_03250)	-	649470..652016 (+)	2547	WP_120770107.1	M1 family metallopeptidase	-
D7D53_RS03255 (D7D53_03255)	ciaR	652124..652798 (+)	675	WP_000590639.1	two-component system response regulator CiaR	Regulator
D7D53_RS03260 (D7D53_03260)	ciaH	652788..654122 (+)	1335	WP_120770108.1	two-component system sensor histidine kinase CiaH	Regulator
D7D53_RS03265 (D7D53_03265)	-	654156..654443 (-)	288	WP_004259451.1	DUF3270 domain-containing protein	-
D7D53_RS03270 (D7D53_03270)	-	654583..655512 (+)	930	WP_004259456.1	peptidase U32 family protein	-
D7D53_RS03275 (D7D53_03275)	rpiA	655618..656301 (+)	684	WP_120770109.1	ribose-5-phosphate isomerase RpiA	-
D7D53_RS03280 (D7D53_03280)	-	656325..657536 (+)	1212	WP_120770110.1	phosphopentomutase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25466.29 Da
• Isoelectric Point: 4.3283

>NTDB_id=317182 D7D53_RS03255 WP_000590639.1 652124..652798(+) (ciaR) [Streptococcus gwangjuensis strain KCOM 1679 (=ChDC B345)]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGYILKDVQ

Nucleotide

• Length: 675 bp

>NTDB_id=317182 D7D53_RS03255 WP_000590639.1 652124..652798(+) (ciaR) [Streptococcus gwangjuensis strain KCOM 1679 (=ChDC B345)]
ATGATAAAAATCTTATTGGTTGAGGATGACCTAGGCCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCAGATGT
CATGCAGGTGTTTGATGGGGAAGAGGGTCTCTACGAAGCTGAGAGTGGTGTCTATGACTTGATTTTGCTCGATTTGATGC
TGCCTGAAAAAAATGGCTTCCAAGTCTTGAAAGAATTGCGTGAAAAGGGAATTACGACACCAGTTCTGATTATGACTGCC
AAGGAAAGTTTGGATGACAAGGGACATGGATTTGAACTGGGAGCGGATGATTATCTGACTAAACCTTTCTATTTAGAAGA
ACTCAAAATGAGGATTCAAGCCCTTCTCAAACGTTCAGGCAAGTTTAATGAAAACACCTTGACTTATGGAAATATTGTAG
TTAATTTGTCAACCAATACCGTTAAGGTTGAAGATACTCCTGTCGAATTGTTGGGGAAAGAGTTCGATTTACTAGTTTAT
TTCCTTCAAAATCAAAATGTTATTTTGCCTAAGACTCAGATTTTTGATCGTCTATGGGGATTTGATAGTGATACAACGAT
TTCGGTTGTCGAAGTCTATGTTTCAAAAGTCCGTAAGAAATTAAAAGGAACCACTTTTGCAGAGAATTTGCAAACCTTGC
GCAGTGTTGGGTATATTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

3D structure

• AlphaFold DB: A0A419RXM2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	99.554	100	0.996
ciaR	Streptococcus pneumoniae D39	99.554	100	0.996
ciaR	Streptococcus pneumoniae R6	99.554	100	0.996
ciaR	Streptococcus pneumoniae TIGR4	99.554	100	0.996
ciaR	Streptococcus mutans UA159	88.839	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	36.726	100	0.371
vicR	Streptococcus mutans UA159	35.622	100	0.371