Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   D7D53_RS03260 Genome accession   NZ_CP032621
Coordinates   652788..654122 (+) Length   444 a.a.
NCBI ID   WP_120770108.1    Uniprot ID   A0A387B2S9
Organism   Streptococcus gwangjuensis strain KCOM 1679 (=ChDC B345)     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 647788..659122
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  D7D53_RS10170 - 647957..648085 (+) 129 Protein_616 NUDIX hydrolase -
  D7D53_RS03240 (D7D53_03240) - 648063..648947 (+) 885 WP_120770105.1 putative PEP-binding protein -
  D7D53_RS03245 (D7D53_03245) - 648907..649347 (+) 441 WP_120770106.1 ASCH domain-containing protein -
  D7D53_RS03250 (D7D53_03250) - 649470..652016 (+) 2547 WP_120770107.1 M1 family metallopeptidase -
  D7D53_RS03255 (D7D53_03255) ciaR 652124..652798 (+) 675 WP_000590639.1 two-component system response regulator CiaR Regulator
  D7D53_RS03260 (D7D53_03260) ciaH 652788..654122 (+) 1335 WP_120770108.1 two-component system sensor histidine kinase CiaH Regulator
  D7D53_RS03265 (D7D53_03265) - 654156..654443 (-) 288 WP_004259451.1 DUF3270 domain-containing protein -
  D7D53_RS03270 (D7D53_03270) - 654583..655512 (+) 930 WP_004259456.1 peptidase U32 family protein -
  D7D53_RS03275 (D7D53_03275) rpiA 655618..656301 (+) 684 WP_120770109.1 ribose-5-phosphate isomerase RpiA -
  D7D53_RS03280 (D7D53_03280) - 656325..657536 (+) 1212 WP_120770110.1 phosphopentomutase -
  D7D53_RS03285 (D7D53_03285) - 657538..658098 (+) 561 WP_120770111.1 DUF1697 domain-containing protein -
  D7D53_RS03290 (D7D53_03290) - 658095..658904 (+) 810 WP_120770112.1 purine-nucleoside phosphorylase -

Sequence

Protein


Download         Length: 444 a.a.        Molecular weight: 50632.31 Da        Isoelectric Point: 9.1616

>NTDB_id=317183 D7D53_RS03260 WP_120770108.1 652788..654122(+) (ciaH) [Streptococcus gwangjuensis strain KCOM 1679 (=ChDC B345)]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAVNRATEEIKDLENAA
TDSSKTEVKPNVSSNTEVILFDKNFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRMILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEKLIVVVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENDRVFRFENRI
HRTIVTDQLLLKQLMTILFDNAIKYTEEDGEIDFVISATDRNLYLLVSDNGVGISAEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGSITVKDNKPKGTIFEVKIAIHTPSKKKK

Nucleotide


Download         Length: 1335 bp        

>NTDB_id=317183 D7D53_RS03260 WP_120770108.1 652788..654122(+) (ciaH) [Streptococcus gwangjuensis strain KCOM 1679 (=ChDC B345)]
ATGTTCAGTAAACTAAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGTAACTTTGGTGTCTTCACTCTGAT
TTTTTCTACCATGACTCTGATTATTTTGCAGGTCATGCATTCGAGTCTCTATACTTCGGTGGATGATAAGCTTCATGGAC
TGAGTGAAAATCCTCAGGCAGTTATTCAGCTGGCAGTAAATAGGGCAACAGAAGAGATTAAAGATTTGGAGAATGCTGCT
ACAGATTCTAGCAAGACTGAGGTGAAACCCAATGTCAGCTCCAATACGGAGGTTATTCTTTTTGATAAGAATTTTACCCA
GCTCCTTTCTGGAAATCGATTTTTGGGCTTGGATAAGATTAAGTTAGAGAAGAAAGAACTAGGCCATATCTATCAGATTC
AGGTTTTTAATAGTTATGGACAGGAAGAAATCTATCGCATGATTTTGATGGAAACGAATATTAGTTCGGTTTCAACCAAT
ATCAAGTATGCAGCTGTCTTGATTAATACCAGTCAGTTGGAGCAGGCTAGTCAAAAGCACGAGAAATTGATTGTGGTCGT
GATGGCAAGTTTCTGGATTTTGTCTTTACTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTCGTCCTCTGCTTGAGAGCA
TGCAGAAGCAGCAGTCCTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCACTCGCAGTTTTGCAAAATCGCTTAGAG
ACCCTTTTCCGTAAGCCAGAAGCTACCATTATGGATGTGAGCGAAAGCATTGCATCGAGTTTGGAAGAAGTCCGAAATAT
GCGGTTTTTGACGACGAACTTGTTGAATTTAGCTCGTAGAGATGATGGGATTAAGCCGGAACTTGCAGAAGTTCCAACCA
GTTTTTTCAATACGACTTTCACAAACTATGAAATGATTGCTTCAGAAAATGACCGTGTCTTCCGTTTTGAAAATCGCATC
CATCGAACAATTGTCACAGATCAACTTCTTTTGAAACAACTGATGACCATCCTATTTGATAATGCTATCAAATATACTGA
AGAGGATGGTGAAATTGATTTTGTGATTTCAGCGACCGATCGCAATCTGTATTTACTTGTTTCTGATAATGGAGTCGGTA
TTTCCGCAGAAGATAAGAAGAAAATATTTGACCGCTTTTATCGAGTGGACAAAGCTAGAACTCGTCAAAAAGGTGGTTTT
GGTTTAGGTTTATCCCTAGCCAAGCAAATTGTAGATGCCCTAAAAGGAAGCATTACTGTTAAAGATAATAAACCAAAAGG
AACAATCTTTGAAGTGAAAATTGCCATCCACACACCATCTAAAAAGAAAAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(217-283)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A387B2S9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

95.946

100

0.959
  ciaH Streptococcus pneumoniae D39

95.946

100

0.959
  ciaH Streptococcus pneumoniae R6

95.946

100

0.959
  ciaH Streptococcus pneumoniae TIGR4

95.946

100

0.959
  ciaH Streptococcus mutans UA159

55.53

97.748

0.543

Multiple sequence alignment