Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SEZ_RS04540 Genome accession   NC_011134
Coordinates   961839..962513 (+) Length   224 a.a.
NCBI ID   WP_012515548.1    Uniprot ID   B4U2R0
Organism   Streptococcus equi subsp. zooepidemicus MGCS10565     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 956839..967513
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SEZ_RS04525 (Sez_0915) pstB 957159..957917 (+) 759 WP_012678019.1 phosphate ABC transporter ATP-binding protein PstB -
  SEZ_RS04530 (Sez_0916) phoU 957988..958641 (+) 654 WP_012515545.1 phosphate signaling complex protein PhoU -
  SEZ_RS04535 (Sez_0917) - 958875..961412 (+) 2538 WP_012515546.1 M1 family metallopeptidase -
  SEZ_RS04540 (Sez_0919) ciaR 961839..962513 (+) 675 WP_012515548.1 response regulator transcription factor Regulator
  SEZ_RS04545 (Sez_0920) ciaH 962506..963816 (+) 1311 WP_012515549.1 HAMP domain-containing sensor histidine kinase Regulator
  SEZ_RS04550 (Sez_0921) - 964202..964633 (+) 432 WP_012515550.1 hypothetical protein -
  SEZ_RS09865 (Sez_0922) - 964715..964891 (+) 177 WP_012515551.1 hypothetical protein -
  SEZ_RS04555 (Sez_0923) - 965064..965447 (+) 384 WP_012515552.1 hypothetical protein -
  SEZ_RS04560 (Sez_0924) - 965444..965704 (+) 261 WP_012515553.1 hypothetical protein -
  SEZ_RS04565 (Sez_0925) - 965723..966133 (+) 411 WP_111721677.1 hypothetical protein -
  SEZ_RS04575 (Sez_0926) - 966348..966743 (+) 396 WP_012515555.1 hypothetical protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25541.52 Da        Isoelectric Point: 4.5644

>NTDB_id=31371 SEZ_RS04540 WP_012515548.1 961839..962513(+) (ciaR) [Streptococcus equi subsp. zooepidemicus MGCS10565]
MIKLLLVEDDLSLSNSIFDFLDDFADVTQVFDGDEGLYEAESGIYDLILLDLMLPEKDGFQVLKALREKDIKIPVLIMTA
KESIDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRVGKFNDKSLKFGNLTVDTTRKEVQVNGQAIELLGKELDLLIY
ILQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTDFVNHLQTLRSVGYILKANE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=31371 SEZ_RS04540 WP_012515548.1 961839..962513(+) (ciaR) [Streptococcus equi subsp. zooepidemicus MGCS10565]
ATGATAAAACTATTATTAGTAGAAGACGATTTAAGCTTGTCAAATTCTATCTTTGATTTTTTAGATGACTTTGCTGATGT
GACGCAGGTTTTTGATGGTGACGAAGGACTCTATGAGGCAGAAAGCGGTATTTATGATTTGATTCTGTTAGATTTGATGC
TGCCTGAAAAGGATGGCTTTCAAGTGTTAAAAGCCTTACGTGAAAAAGACATCAAAATTCCCGTCTTGATCATGACTGCC
AAAGAAAGCATCGATGACAAAGGGCATGGCTTTGAGCTTGGTGCTGATGACTATTTAACCAAGCCCTTTTACCTAGAAGA
ATTAAAAATGCGGATTCAGGCCTTGCTTAAGCGCGTAGGAAAGTTTAATGATAAGAGCCTTAAATTTGGCAACTTGACTG
TAGATACTACCCGTAAAGAGGTACAGGTCAATGGGCAGGCCATAGAGCTATTAGGCAAGGAGCTTGATTTACTAATCTAT
ATCCTTCAAAATCAAAATGTTATTTTGCCAAAATCACAAATTTTTGATCGTATCTGGGGCTTTGATAGTGATACCACTAT
CTCTGTTGTAGAGGTCTATGTCTCTAAAATTCGTAAGAAGCTTAAGGGGACAGACTTTGTTAATCATCTTCAAACCTTGA
GAAGTGTAGGATATATCTTAAAAGCTAATGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B4U2R0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

84.615

98.661

0.835
  ciaR Streptococcus pneumoniae Rx1

80.543

98.661

0.795
  ciaR Streptococcus pneumoniae D39

80.543

98.661

0.795
  ciaR Streptococcus pneumoniae R6

80.543

98.661

0.795
  ciaR Streptococcus pneumoniae TIGR4

80.543

98.661

0.795
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.428

100

0.393
  covR Streptococcus salivarius strain HSISS4

35.841

100

0.362

Multiple sequence alignment