Detailed information NTG0311110

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: D1F63_RS05390
• Genome accession: NZ_CP031770
• Coordinates: 1005506..1006342 (+)
• Length: 278 a.a.
• NCBI ID: WP_011017772.1
• Uniprot ID: A0A660A2Q7
• Organism: Streptococcus pyogenes strain SASM4-Duke
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 1000506..1011342

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
D1F63_RS05360 (D1F63_05360)	-	1000994..1001428 (+)	435	WP_021299262.1	hypothetical protein	-
D1F63_RS05365 (D1F63_05365)	-	1001478..1002389 (-)	912	WP_011528643.1	diacylglycerol kinase family protein	-
D1F63_RS05370 (D1F63_05370)	-	1002506..1003156 (-)	651	WP_002984629.1	hemolysin III family protein	-
D1F63_RS05375 (D1F63_05375)	-	1003153..1003593 (-)	441	WP_011017769.1	DUF1836 domain-containing protein	-
D1F63_RS05380 (D1F63_05380)	ylqF	1003812..1004660 (+)	849	WP_011017770.1	ribosome biogenesis GTPase YlqF	-
D1F63_RS05385 (D1F63_05385)	-	1004650..1005441 (+)	792	WP_011017771.1	ribonuclease HII	-
D1F63_RS05390 (D1F63_05390)	dprA	1005506..1006342 (+)	837	WP_011017772.1	DNA-processing protein DprA	Machinery gene
D1F63_RS05395 (D1F63_05395)	topA	1006449..1008578 (+)	2130	WP_011528644.1	type I DNA topoisomerase	-
D1F63_RS09905	-	1008654..1009538 (-)	885	Protein_995	LysR family transcriptional regulator	-
D1F63_RS05410 (D1F63_05410)	-	1009551..1010117 (+)	567	Protein_996	PTS sugar transporter subunit IIC	-
D1F63_RS05415 (D1F63_05415)	-	1010132..1011124 (+)	993	WP_021299266.1	D-lactate dehydrogenase	-

Sequence

Protein

• Length: 278 a.a.
• Molecular weight: 31088.08 Da
• Isoelectric Point: 9.0513

>NTDB_id=311110 D1F63_RS05390 WP_011017772.1 1005506..1006342(+) (dprA) [Streptococcus pyogenes strain SASM4-Duke]
MNHFELYKLKKAGLTNKNILNILDYQEHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPREEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGATCVTSGMDILSEY

Nucleotide

• Length: 837 bp

>NTDB_id=311110 D1F63_RS05390 WP_011017772.1 1005506..1006342(+) (dprA) [Streptococcus pyogenes strain SASM4-Duke]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCCGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTTGGCTCCAGACGCTCAAGCGATACCGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAACCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACCATC
GCTATTATTGGAACAGGGTTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAAGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAACATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (68-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: A0A660A2Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	67.626	100	0.676
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae D39	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae R6	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis SK321	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	60.072	100	0.601
dprA	Lactococcus lactis subsp. cremoris KW2	57.194	100	0.572
dprA	Legionella pneumophila strain ERS1305867	42.857	85.612	0.367