Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Machinery gene
Locus tag   DV389_RS04140 Genome accession   NZ_CP031250
Coordinates   840165..841502 (-) Length   445 a.a.
NCBI ID   WP_114893182.1    Uniprot ID   -
Organism   Haemophilus influenzae strain M21384     
Function   type IV pilus biogenesis and function (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 835165..846502
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DV389_RS04115 (DV389_04115) - 836895..837167 (-) 273 WP_005630954.1 HU family DNA-binding protein -
  DV389_RS04120 (DV389_04120) - 837306..837896 (-) 591 WP_114893178.1 DUF416 family protein -
  DV389_RS04125 (DV389_04125) nudC 837932..838726 (-) 795 WP_114893179.1 NAD(+) diphosphatase -
  DV389_RS04130 (DV389_04130) nfuA 838794..839390 (-) 597 WP_114893180.1 Fe-S biogenesis protein NfuA -
  DV389_RS04135 (DV389_04135) - 839466..840152 (-) 687 WP_162816767.1 ComF family protein -
  DV389_RS04140 (DV389_04140) comE 840165..841502 (-) 1338 WP_114893182.1 type IV pilus secretin PilQ Machinery gene
  DV389_RS04145 (DV389_04145) comD 841512..841925 (-) 414 WP_114893183.1 pilus assembly protein PilP Machinery gene
  DV389_RS04150 (DV389_04150) comC 841943..842443 (-) 501 WP_114893184.1 competence protein ComC Machinery gene
  DV389_RS04155 (DV389_04155) comB 842440..842946 (-) 507 WP_114893185.1 competence protein B Machinery gene
  DV389_RS04160 (DV389_04160) comA 842947..843744 (-) 798 WP_114893186.1 pilus assembly protein PilM Machinery gene
  DV389_RS04165 (DV389_04165) - 843843..846443 (+) 2601 WP_114893187.1 penicillin-binding protein 1A -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 49044.36 Da        Isoelectric Point: 8.2552

>NTDB_id=304949 DV389_RS04140 WP_114893182.1 840165..841502(-) (comE) [Haemophilus influenzae strain M21384]
MKKYFLKCGYFLVCFCLPLIVFANPKTDNERFFIRLSQAPLAQTLEQLAFQQDVNLVIGDTLENKISLKLNNIDMPRLLQ
IIAKSKKLTLNKDEGIYYLNGGLSGKGQVAGNLTTNEPHLVSHTVKLHFAKASELMKSLTTGSGSLLSSAGSITFDDRSN
LLVIQDEPRSVQNIKKLIAEMDKPIEQIAIEARIVTITDESLKELGVRWGIFNPTENARRVAGSLAGNSFENIADNLNVN
FATTATPAGSIALQVAKINGRLLDLELSALERENNVEIIASPRLLTTNKKSASIKQGTEIPYVVSNTRNDTQSVEFREAV
LGLEVTPHISKDNNILLDLLVSQNSPGSRVSYGQNEVVSIDKQEINTQVFAKDGETIVLGGVFHDTITKSEDKVPLLGDI
PVIKRLFSKESERHQKRELVIFVTPHILKAGETLDVLKQKSAGKK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=304949 DV389_RS04140 WP_114893182.1 840165..841502(-) (comE) [Haemophilus influenzae strain M21384]
ATGAAGAAATATTTTTTAAAGTGCGGTTATTTTCTAGTGTGTTTTTGTTTGCCATTAATCGTTTTTGCTAATCCCAAAAC
TGATAACGAACGTTTTTTTATTCGTTTATCGCAAGCACCTTTAGCCCAAACATTGGAACAGTTGGCTTTTCAACAAGATG
TGAATTTAGTGATTGGAGATACATTGGAAAACAAGATCTCTTTGAAATTAAACAATATTGATATGCCACGTTTGCTACAA
ATAATCGCTAAAAGTAAGAAGCTTACTTTGAATAAAGATGAGGGCATTTACTATCTGAATGGAGGGCTATCAGGCAAAGG
GCAAGTTGCAGGAAATCTTACTACAAATGAACCGCACTTAGTGAGTCACACGGTAAAACTCCATTTTGCTAAAGCCTCTG
AATTAATGAAGTCCTTAACAACAGGAAGTGGCTCTTTGCTTTCATCAGCTGGGAGCATTACCTTTGATGATCGTAGTAAT
TTGCTCGTGATTCAAGATGAACCTCGTTCTGTGCAAAATATTAAAAAACTAATTGCTGAAATGGATAAACCTATTGAGCA
GATTGCTATTGAAGCACGTATTGTGACAATTACGGATGAAAGTTTGAAAGAACTTGGCGTTCGGTGGGGGATTTTTAATC
CAACGGAAAATGCAAGACGAGTTGCGGGCAGTCTTGCAGGCAATAGCTTTGAAAATATTGCGGATAATCTTAATGTAAAT
TTTGCGACAACGGCGACACCTGCTGGCTCGATAGCATTACAAGTCGCGAAAATTAATGGGCGATTGCTCGATTTAGAATT
AAGCGCGTTAGAGCGTGAAAATAATGTGGAAATTATCGCAAGTCCTCGCTTACTCACTACCAATAAGAAAAGTGCGAGCA
TTAAACAGGGTACAGAAATTCCTTATGTTGTGAGCAATACTCGTAATGATACACAATCTGTGGAATTTCGCGAGGCGGTG
CTTGGTTTGGAAGTCACTCCACATATTTCTAAAGATAACAATATCTTGCTTGATTTATTAGTGAGCCAAAATTCTCCCGG
TTCTCGAGTTTCTTATGGACAAAACGAGGTGGTTTCTATTGATAAGCAAGAAATTAATACTCAGGTTTTTGCCAAAGATG
GGGAAACCATTGTACTTGGCGGTGTATTCCACGACACAATCACGAAAAGCGAAGATAAAGTGCCATTACTTGGCGATATA
CCCGTTATTAAACGATTATTCAGCAAAGAAAGCGAACGACATCAAAAACGTGAGTTAGTGATTTTTGTCACTCCGCATAT
TTTAAAAGCAGGAGAAACGTTAGATGTTTTGAAACAAAAAAGTGCGGGCAAAAAATAA

Domains

Predicted by InterproScan.

Bacterial type II and III secretion system protein (Secretin)

(269-429)

Bacterial type II/III secretion system short domain (Secretin_N)

(123-187)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Haemophilus influenzae Rd KW20

97.079

100

0.971
  comE Haemophilus influenzae 86-028NP

95.73

100

0.957
  comE Glaesserella parasuis strain SC1401

52.471

95.506

0.501
  pilQ Vibrio campbellii strain DS40M4

42.721

94.157

0.402
  pilQ Vibrio cholerae O1 biovar El Tor strain E7946

42.233

92.584

0.391
  pilQ Vibrio cholerae strain A1552

42.233

92.584

0.391

Multiple sequence alignment