Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEA/celA/cilE   Type   Machinery gene
Locus tag   DV129_RS03240 Genome accession   NZ_CP031247
Coordinates   606354..607004 (-) Length   216 a.a.
NCBI ID   WP_000387352.1    Uniprot ID   A0A4J1SCX2
Organism   Streptococcus pneumoniae strain M23734     
Function   dsDNA binding to the cell surface (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 601354..612004
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DV129_RS03220 - 601955..603139 (-) 1185 WP_000655953.1 hypothetical protein -
  DV129_RS03225 - 603143..603730 (-) 588 WP_000939895.1 ABC transporter ATP-binding protein -
  DV129_RS03230 - 603763..603951 (-) 189 WP_001812421.1 hypothetical protein -
  DV129_RS03235 comEC/celB 604130..606370 (-) 2241 WP_114865969.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  DV129_RS03240 comEA/celA/cilE 606354..607004 (-) 651 WP_000387352.1 helix-hairpin-helix domain-containing protein Machinery gene
  DV129_RS03245 - 607072..607641 (-) 570 WP_000443745.1 GNAT family N-acetyltransferase -
  DV129_RS03250 ald 607818..608929 (+) 1112 Protein_620 alanine dehydrogenase -
  DV129_RS03255 - 609230..609556 (-) 327 Protein_621 TfoX/Sxy family protein -
  DV129_RS03260 - 609559..610059 (-) 501 WP_000566988.1 GNAT family N-acetyltransferase -
  DV129_RS03265 - 610239..611207 (-) 969 WP_000658180.1 PhoH family protein -
  DV129_RS03270 - 611293..611508 (-) 216 WP_001232078.1 YozE family protein -

Sequence

Protein


Download         Length: 216 a.a.        Molecular weight: 23085.30 Da        Isoelectric Point: 6.0661

>NTDB_id=304754 DV129_RS03240 WP_000387352.1 606354..607004(-) (comEA/celA/cilE) [Streptococcus pneumoniae strain M23734]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTSVKETNLQAEVAAVSKDSSTGKEVNKEEKEEPVEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGSGTASSTSKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGAKTIEKLKDYVTVD

Nucleotide


Download         Length: 651 bp        

>NTDB_id=304754 DV129_RS03240 WP_000387352.1 606354..607004(-) (comEA/celA/cilE) [Streptococcus pneumoniae strain M23734]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGCGGATT
TTTCCTGCTAAAGCCAGCTCCACAAACATCTGTCAAAGAGACGAATTTGCAGGCTGAAGTTGCAGCTGTTTCCAAGGACT
CATCGACCGGAAAGGAAGTGAACAAGGAAGAGAAGGAAGAACCAGTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGTCAACAGACTGGTTCGGGGACAGCTTCTTCAACAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATTGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGCCAAGACCATAGAAAAACTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

Helix-hairpin-helix motif (HHH_3)

(151-214)

SLBB domain (SLBB)

(76-126)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4J1SCX2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEA/celA/cilE Streptococcus pneumoniae TIGR4

97.685

100

0.977
  comEA/celA/cilE Streptococcus pneumoniae Rx1

95.833

100

0.958
  comEA/celA/cilE Streptococcus pneumoniae D39

95.833

100

0.958
  comEA/celA/cilE Streptococcus pneumoniae R6

95.833

100

0.958
  comEA/celA/cilE Streptococcus mitis NCTC 12261

95.37

100

0.954
  comEA/celA/cilE Streptococcus mitis SK321

92.593

100

0.926
  comEA Lactococcus lactis subsp. cremoris KW2

44.053

100

0.463
  comEA Latilactobacillus sakei subsp. sakei 23K

34.335

100

0.37

Multiple sequence alignment