Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Machinery gene
Locus tag   DV365_RS00590 Genome accession   NZ_CP031237
Coordinates   114335..115672 (+) Length   445 a.a.
NCBI ID   WP_114890069.1    Uniprot ID   -
Organism   Haemophilus influenzae strain M12125     
Function   type IV pilus biogenesis and function (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 109335..120672
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DV365_RS00565 - 109400..111994 (-) 2595 WP_114890066.1 penicillin-binding protein 1A -
  DV365_RS00570 comA 112093..112890 (+) 798 WP_114890067.1 competence protein ComA Machinery gene
  DV365_RS00575 comB 112891..113397 (+) 507 WP_114890068.1 competence protein ComB Machinery gene
  DV365_RS00580 comC 113394..113915 (+) 522 WP_048951462.1 competence protein ComC Machinery gene
  DV365_RS00585 comD 113912..114325 (+) 414 WP_005693727.1 pilus assembly protein PilP Machinery gene
  DV365_RS00590 comE 114335..115672 (+) 1338 WP_114890069.1 type IV pilus secretin PilQ family protein Machinery gene
  DV365_RS00595 - 115685..116371 (+) 687 WP_032823982.1 ComF family protein -
  DV365_RS00600 nfuA 116447..117043 (+) 597 WP_005649300.1 Fe-S biogenesis protein NfuA -
  DV365_RS00605 nudC 117110..117904 (+) 795 WP_114890070.1 NAD(+) diphosphatase -
  DV365_RS00610 - 117940..118530 (+) 591 WP_005652133.1 YjaG family protein -
  DV365_RS00615 - 118670..118942 (+) 273 WP_114890071.1 HU family DNA-binding protein -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 49111.38 Da        Isoelectric Point: 7.8654

>NTDB_id=304352 DV365_RS00590 WP_114890069.1 114335..115672(+) (comE) [Haemophilus influenzae strain M12125]
MKKYFLKCGYFLVCFCLPLIVFANPKTDNERFFIRLSQAPLAQTLEQLAFQQDVNLVMGERLEGNISLKLDNIDMPRLLK
IIAKSKHLTLNKDDGVYYLNGSQSGKGQVAGNLTTNEPHLVSHTVKLHFAKASELMKSLTTGSGSLLSPAGSITFDDRSN
LLVIQDEPRSVQNIKKLIAEMDKPIEQIAIEARIVTITDESLKELGVRWGIFNPTENARRVAGSLTGNSFENIADNLNVN
FATTTTPAGSIALQVAKINGRLLDLELSALERENNVEIIASPRLLTTNKKSASIKQGAEIPYIVSNTRNDTQSVEFREAV
LGLEVTPHISKDNNILLDLLVSQNSPGSRVAYGQNEVVSIDKQEINTQVFAKDGETIVLGGVFHDTITKSEDKVPLLGDI
PVIKRLFSKESERHQKRELVIFVTPHILKAGETLEALKQKSAGKK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=304352 DV365_RS00590 WP_114890069.1 114335..115672(+) (comE) [Haemophilus influenzae strain M12125]
ATGAAGAAATATTTTTTAAAGTGCGGTTATTTTTTAGTGTGTTTTTGTTTGCCATTAATCGTTTTTGCTAATCCTAAAAC
AGATAACGAACGTTTTTTTATTCGTTTATCGCAAGCACCTTTAGCTCAAACACTGGAGCAATTAGCTTTTCAACAAGATG
TGAATTTAGTGATGGGTGAGAGGTTAGAAGGCAATATTTCTTTGAAATTAGATAATATTGATATGCCACGTTTGCTAAAA
ATAATCGCAAAAAGTAAGCATCTTACTTTGAATAAAGATGATGGGGTTTATTATTTAAACGGCAGTCAATCTGGCAAAGG
TCAAGTTGCAGGAAATCTTACGACAAATGAACCGCACTTAGTCAGCCACACGGTAAAACTTCATTTTGCTAAAGCCTCTG
AATTAATGAAATCCTTAACAACAGGAAGTGGATCTTTGCTTTCTCCCGCTGGGAGCATTACCTTTGATGATCGCAGTAAT
TTGCTGGTTATTCAGGATGAACCTCGTTCTGTGCAAAATATCAAAAAACTGATTGCTGAAATGGATAAGCCTATTGAACA
GATCGCTATTGAAGCGCGAATTGTGACAATTACGGATGAGAGTTTGAAAGAACTTGGCGTTCGGTGGGGGATTTTTAATC
CAACTGAAAATGCAAGACGAGTTGCGGGCAGCCTTACAGGCAATAGCTTTGAAAATATTGCGGATAATCTTAATGTAAAT
TTTGCGACAACGACGACACCTGCTGGCTCTATAGCATTACAAGTCGCGAAAATTAATGGGCGATTGCTTGATTTAGAATT
GAGTGCGTTGGAGCGTGAAAATAATGTAGAAATTATTGCAAGTCCTCGCTTACTCACTACCAATAAGAAAAGTGCGAGCA
TTAAACAGGGGGCAGAAATTCCTTACATCGTGAGTAATACTCGTAACGATACGCAATCTGTGGAATTTCGTGAGGCAGTA
CTTGGTTTGGAAGTGACGCCACATATTTCTAAAGATAACAATATCTTACTTGATTTATTGGTAAGTCAAAATTCCCCTGG
TTCTCGTGTCGCTTATGGACAAAATGAGGTGGTTTCTATTGATAAGCAAGAAATTAATACTCAGGTTTTTGCCAAAGATG
GGGAAACCATTGTGCTTGGCGGCGTATTTCACGACACAATCACGAAAAGCGAAGATAAAGTGCCATTGCTTGGCGATATA
CCCGTTATTAAACGATTATTTAGCAAAGAAAGTGAACGACATCAAAAACGTGAGCTAGTGATTTTCGTGACGCCACATAT
TTTAAAAGCAGGAGAAACGTTAGAGGCGTTGAAACAAAAAAGTGCGGGGAAAAAATAA

Domains

Predicted by InterproScan.

Bacterial type II and III secretion system protein (Secretin)

(269-429)

Bacterial type II/III secretion system short domain (Secretin_N)

(123-187)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Haemophilus influenzae 86-028NP

98.876

100

0.989
  comE Haemophilus influenzae Rd KW20

97.753

100

0.978
  comE Glaesserella parasuis strain SC1401

52

95.506

0.497
  pilQ Vibrio campbellii strain DS40M4

42.959

94.157

0.404
  pilQ Vibrio cholerae O1 biovar El Tor strain E7946

42.233

92.584

0.391
  pilQ Vibrio cholerae strain A1552

42.233

92.584

0.391

Multiple sequence alignment