Detailed information NTG0302014

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: ETT60_RS02215
• Genome accession: NZ_CP035439
• Coordinates: 407133..409286 (-)
• Length: 717 a.a.
• NCBI ID: WP_129284363.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm77
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 402133..414286

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT60_RS02195 (ETT60_02195)	comE/blpR	403324..404073 (+)	750	WP_030126108.1	response regulator transcription factor	Regulator
ETT60_RS02200 (ETT60_02200)	-	404074..405408 (+)	1335	WP_063631787.1	sensor histidine kinase	-
ETT60_RS02205 (ETT60_02205)	-	405556..405681 (-)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
ETT60_RS02210 (ETT60_02210)	-	405758..407122 (-)	1365	WP_129284364.1	bacteriocin secretion accessory protein	-
ETT60_RS02215 (ETT60_02215)	comA/nlmT	407133..409286 (-)	2154	WP_129284363.1	peptide cleavage/export ABC transporter	Regulator
ETT60_RS02225 (ETT60_02225)	-	409737..410422 (+)	686	Protein_374	transposase	-
ETT60_RS02230 (ETT60_02230)	-	410609..410854 (+)	246	WP_002994504.1	Blp family class II bacteriocin	-
ETT60_RS02235 (ETT60_02235)	-	410869..411051 (+)	183	WP_002987564.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
ETT60_RS02240 (ETT60_02240)	-	411271..411956 (-)	686	Protein_377	transposase	-
ETT60_RS02245 (ETT60_02245)	-	412274..412501 (+)	228	WP_002992018.1	Blp family class II bacteriocin	-
ETT60_RS02250 (ETT60_02250)	-	412514..412714 (+)	201	WP_003060803.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
ETT60_RS02260 (ETT60_02260)	-	413008..413202 (+)	195	WP_002990768.1	hypothetical protein	-
ETT60_RS02265 (ETT60_02265)	-	413252..413533 (+)	282	WP_111705488.1	hypothetical protein	-
ETT60_RS02270 (ETT60_02270)	-	413727..414137 (+)	411	WP_129284149.1	hypothetical protein	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80562.50 Da
• Isoelectric Point: 7.0109

>NTDB_id=302014 ETT60_RS02215 WP_129284363.1 407133..409286(-) (comA/nlmT) [Streptococcus pyogenes strain emm77]
MISYRKTFVAQIDARDCGVAALASIAKYYGSDYSLAHLRELAKTNKEGTTALGIVKAAKLMGFETRAIQADMTLFDIEDV
PYPFIVHVNKEGKFQHYYVIYQNKKNYLIIGDPDSTVKVTKMTKERFTSEWTGVAIFLAPEPSYKPHKDKKNGLISFLPL
IFKQRSLIFYIILASLLVTLINIVGSYYLQGILDDYIPNQLKSTLGIISIGLIITYILQQMMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANAIIDALASTILSLFLDVSILTIVGTVLLVQNTNLFLLSLVSVPLYIV
IIFIFMHPFEKMNNDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQKIDSEFVDYLDKSFKLSKYSILQSSLKQGAQL
ILNVIVLWFGAKLVMGGKISVGQLITFNTLLSYFTNPLENIINLQTKLQSAKVANNRLNEVYLVDSEFQEAGTLVNQELL
HGDIQFEELSYKYGFGRDTLSNINLTIKQGDKVSLVGISGSGKTTLAKMIVNFFEPYNGRITINHNDLKMIDKKSLRQHI
NYLPQQAYIFNGSILENLTLGANDCTSHEDILRACEVAEIRQDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKRVIDNLLAMTDKTIIFVAHRLSISARTNQVIVLDEGKIIEIGSHQELMTKQGFYHHLFSS

Nucleotide

• Length: 2154 bp

>NTDB_id=302014 ETT60_RS02215 WP_129284363.1 407133..409286(-) (comA/nlmT) [Streptococcus pyogenes strain emm77]
ATGATATCCTATCGAAAAACATTTGTTGCTCAGATTGATGCTAGAGACTGTGGTGTGGCTGCTCTTGCTTCCATCGCTAA
ATATTACGGTTCAGACTACTCTTTAGCTCATTTAAGAGAGTTAGCTAAAACAAATAAAGAGGGAACAACAGCGCTTGGCA
TCGTCAAAGCTGCCAAATTAATGGGATTTGAAACAAGAGCTATTCAAGCAGACATGACCCTCTTTGATATAGAAGATGTC
CCTTATCCTTTTATTGTTCATGTTAATAAAGAAGGTAAATTCCAACACTACTATGTCATCTATCAAAACAAAAAAAATTA
TCTGATAATCGGCGACCCTGACTCGACAGTAAAAGTCACTAAGATGACAAAGGAGCGATTTACTTCTGAATGGACGGGTG
TCGCTATTTTTCTAGCACCCGAGCCCAGCTACAAGCCTCATAAGGACAAAAAGAACGGTCTAATAAGCTTTTTACCTCTC
ATTTTTAAACAGCGATCTCTGATTTTCTATATCATATTAGCTAGCCTACTCGTTACTCTGATTAATATTGTAGGTTCTTA
TTACCTACAAGGTATATTAGATGACTATATTCCAAATCAACTGAAATCAACACTCGGCATTATTTCAATTGGTCTTATCA
TTACCTATATCCTCCAACAGATGATGAGTTTTTCGCGAGATTATCTCCTGACTGTACTGAGTCAGCGATTAAGCATTGAT
GTTATTTTATCCTATATTCGTCATATTTTTGAGCTTCCCATGTCTTTTTTTGCAACTCGCAGAACAGGAGAAATCATCTC
ACGTTTTACAGATGCTAATGCTATTATTGATGCACTCGCTTCTACTATTTTGTCTCTTTTTCTTGATGTCAGTATTTTAA
CTATCGTAGGGACAGTCCTGTTAGTGCAAAATACCAATCTTTTTCTTCTATCTCTGGTTTCAGTCCCTCTATATATTGTT
ATTATCTTTATATTTATGCACCCATTTGAAAAGATGAATAATGATGTCATGCAGAGTAACTCTATGGTTAGCTCAGCCAT
TATCGAAGATATCAATGGCATTGAAACTATTAAATCACTGACCAGTGAAGAAAATCGTTATCAGAAAATTGATAGTGAAT
TTGTGGACTATCTGGATAAATCCTTCAAGTTAAGTAAGTACTCTATTTTACAAAGCAGTCTCAAACAAGGGGCGCAACTA
ATCCTTAACGTGATAGTCTTATGGTTTGGGGCCAAATTAGTTATGGGAGGAAAAATTTCTGTTGGTCAGTTGATTACGTT
TAATACTCTCTTATCTTATTTTACCAATCCTTTAGAAAATATCATTAATCTTCAAACTAAACTGCAATCAGCCAAGGTAG
CTAATAATCGTCTCAATGAAGTTTACCTAGTCGATTCTGAGTTTCAAGAGGCTGGGACATTAGTCAATCAAGAATTATTA
CACGGAGACATTCAATTTGAAGAGTTATCCTATAAATATGGCTTTGGACGCGATACTCTATCAAATATTAATCTCACTAT
TAAGCAAGGGGACAAAGTTAGCCTTGTTGGTATTAGTGGATCTGGTAAAACGACTCTAGCTAAAATGATTGTTAATTTTT
TTGAGCCTTATAACGGCCGAATTACCATTAATCATAATGACTTAAAAATGATTGATAAAAAAAGTCTTCGCCAACATATT
AATTATCTCCCCCAACAAGCCTATATTTTTAATGGTTCTATTTTAGAAAATTTAACCTTAGGTGCTAATGACTGTACTAG
TCATGAAGATATTCTAAGAGCTTGTGAGGTTGCAGAAATTCGACAAGATATTGAACAAATGCCTATGGGCTATCAAACAG
AGCTTTCTGATGGTGCCGGACTCTCAGGAGGCCAAAAGCAACGAATTGCACTTGCCAGAGCTCTCCTAACCAAGGCGCCT
GTGCTTATTCTAGATGAGGCTACAAGCGGTCTTGACGTACTAACTGAAAAGAGGGTTATTGATAATCTTTTGGCTATGAC
GGATAAAACTATTATTTTCGTAGCTCATCGTCTCAGCATTTCAGCGCGGACCAATCAAGTCATTGTGCTTGATGAGGGTA
AAATTATTGAAATAGGATCTCATCAAGAATTAATGACTAAACAAGGTTTCTATCATCATTTATTTAGTAGTTAA

Domains

Predicted by InterProScan.

• ABC transporter transmembrane region (ABC_membrane) (168-438)

• ABC transporter (ABC_tran) (500-649)

• Peptidase C39 family (Peptidase_C39) (7-142)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	72.587	99.721	0.724
comA	Streptococcus mitis NCTC 12261	67.367	99.582	0.671
comA	Streptococcus mitis SK321	66.947	99.582	0.667
comA	Streptococcus pneumoniae Rx1	66.947	99.582	0.667
comA	Streptococcus pneumoniae D39	66.947	99.582	0.667
comA	Streptococcus pneumoniae R6	66.947	99.582	0.667
comA	Streptococcus pneumoniae TIGR4	66.667	99.582	0.664
comA	Streptococcus gordonii str. Challis substr. CH1	65.738	100	0.658