Detailed information NTG0299431

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: DP111_RS05905
• Genome accession: NZ_CP030124
• Coordinates: 1158291..1158962 (-)
• Length: 223 a.a.
• NCBI ID: WP_024385291.1
• Uniprot ID: A0A116K182
• Organism: Streptococcus suis strain SH1510
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1153291..1163962

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DP111_RS05880 (DP111_05880)	coaA	1153877..1154797 (+)	921	WP_024381359.1	type I pantothenate kinase	-
DP111_RS05885 (DP111_05885)	rpsT	1154856..1155104 (+)	249	WP_012027069.1	30S ribosomal protein S20	-
DP111_RS05890 (DP111_05890)	-	1155366..1156595 (-)	1230	WP_024394628.1	transglutaminase domain-containing protein	-
DP111_RS05900 (DP111_05900)	ciaH	1156919..1158298 (-)	1380	WP_024394629.1	HAMP domain-containing sensor histidine kinase	Regulator
DP111_RS05905 (DP111_05905)	ciaR	1158291..1158962 (-)	672	WP_024385291.1	response regulator transcription factor	Regulator
DP111_RS11440	-	1159156..1159344 (-)	189	WP_225533284.1	hypothetical protein	-
DP111_RS05915 (DP111_05915)	phoU	1159657..1160313 (-)	657	WP_024394630.1	phosphate signaling complex protein PhoU	-
DP111_RS05920 (DP111_05920)	pstB	1160342..1161100 (-)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
DP111_RS05925 (DP111_05925)	pstB	1161112..1161915 (-)	804	WP_002937615.1	phosphate ABC transporter ATP-binding protein PstB	-
DP111_RS05930 (DP111_05930)	pstA	1161940..1162827 (-)	888	WP_002937616.1	phosphate ABC transporter permease PstA	-
DP111_RS05935 (DP111_05935)	pstC	1162817..1163734 (-)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25231.80 Da
• Isoelectric Point: 4.2183

>NTDB_id=299431 DP111_RS05905 WP_024385291.1 1158291..1158962(-) (ciaR) [Streptococcus suis strain SH1510]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGVYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=299431 DP111_RS05905 WP_024385291.1 1158291..1158962(-) (ciaR) [Streptococcus suis strain SH1510]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGTCTATCAAATTCTGTTTTCGATTTCTTAGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGCGTTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTAATGT
TGCCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAATTACGTGAAAAAGGTGTTACGACACCTGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGGGCTGATGACTATTTGACGAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACTTATGGGGACGTGACCG
TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTAGTCTAC
TTCTTGCAAAATCAAAATGTTATCTTACCAAAAACTCAAATTTTTGACCGTATTTGGGGATTTGACAGTGACACTACTAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: A0A116K182

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.789	100	0.888
ciaR	Streptococcus pneumoniae D39	88.789	100	0.888
ciaR	Streptococcus pneumoniae R6	88.789	100	0.888
ciaR	Streptococcus pneumoniae TIGR4	88.789	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.053	100	0.386
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.368