Detailed information    

insolico Bioinformatically predicted

Overview

Name   stkP   Type   Regulator
Locus tag   DK877_RS02250 Genome accession   NZ_CP030023
Coordinates   432160..434154 (+) Length   664 a.a.
NCBI ID   WP_009909429.1    Uniprot ID   -
Organism   Streptococcus suis strain ISU2414     
Function   require for competence development; phosphorylate ComE (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 432160..462923 432160..434154 within 0


Gene organization within MGE regions


Location: 432160..462923
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DK877_RS02250 (DK877_02315) stkP 432160..434154 (+) 1995 WP_009909429.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  DK877_RS02255 (DK877_02320) liaF 434611..435270 (+) 660 WP_226964025.1 cell wall-active antibiotics response protein LiaF -
  DK877_RS02260 (DK877_02325) - 435267..436283 (+) 1017 WP_002937028.1 sensor histidine kinase -
  DK877_RS02265 (DK877_02330) - 436255..436896 (+) 642 WP_002937025.1 response regulator transcription factor -
  DK877_RS02270 (DK877_02335) - 436946..438346 (+) 1401 WP_002937018.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  DK877_RS02275 (DK877_02340) - 438348..438719 (+) 372 WP_002937017.1 S1 RNA-binding domain-containing protein -
  DK877_RS02280 (DK877_02345) cysK 438746..439672 (-) 927 WP_002937015.1 cysteine synthase A -
  DK877_RS02285 (DK877_02350) - 439902..441059 (-) 1158 WP_024409220.1 site-specific integrase -
  DK877_RS02290 (DK877_02355) - 441256..441987 (-) 732 WP_013730164.1 hypothetical protein -
  DK877_RS02295 (DK877_02360) - 442035..442418 (-) 384 WP_013730165.1 ImmA/IrrE family metallo-endopeptidase -
  DK877_RS02300 (DK877_02365) - 442425..442973 (-) 549 WP_236685406.1 helix-turn-helix domain-containing protein -
  DK877_RS02305 (DK877_02370) - 442990..443190 (+) 201 WP_002937001.1 helix-turn-helix domain-containing protein -
  DK877_RS02310 (DK877_02375) - 443260..443586 (+) 327 WP_013730166.1 hypothetical protein -
  DK877_RS02315 (DK877_02380) - 443660..443914 (+) 255 WP_013730167.1 hypothetical protein -
  DK877_RS02320 (DK877_02385) - 443970..444203 (+) 234 WP_226960628.1 hypothetical protein -
  DK877_RS02325 - 444193..444345 (+) 153 WP_022540561.1 hypothetical protein -
  DK877_RS02330 (DK877_02390) - 444350..444691 (+) 342 WP_013730169.1 hypothetical protein -
  DK877_RS02335 (DK877_02395) - 444691..445170 (+) 480 WP_013730170.1 siphovirus Gp157 family protein -
  DK877_RS02340 (DK877_02400) - 445167..445412 (+) 246 WP_013730171.1 hypothetical protein -
  DK877_RS02345 (DK877_02405) - 445393..445857 (+) 465 WP_013730172.1 hypothetical protein -
  DK877_RS02350 (DK877_02410) - 445826..446998 (+) 1173 WP_013730173.1 DEAD/DEAH box helicase family protein -
  DK877_RS02355 (DK877_02415) - 447072..447338 (+) 267 WP_226960629.1 hypothetical protein -
  DK877_RS02360 (DK877_02420) - 447348..448046 (+) 699 WP_013730175.1 ERF family protein -
  DK877_RS02365 (DK877_02425) - 448046..448342 (+) 297 WP_022540564.1 hypothetical protein -
  DK877_RS02370 (DK877_02430) ssbA 448339..448737 (+) 399 WP_022540565.1 single-stranded DNA-binding protein Machinery gene
  DK877_RS02375 (DK877_02435) - 448748..449575 (+) 828 WP_013730177.1 bifunctional DNA primase/polymerase -
  DK877_RS02380 (DK877_02440) - 449559..450938 (+) 1380 WP_079253058.1 virulence-associated E family protein -
  DK877_RS02385 - 451295..451450 (+) 156 WP_013730179.1 hypothetical protein -
  DK877_RS02390 (DK877_02445) - 451447..451755 (+) 309 WP_013730180.1 DUF1372 family protein -
  DK877_RS02395 (DK877_02450) - 451757..451972 (+) 216 WP_013730181.1 hypothetical protein -
  DK877_RS02400 (DK877_02455) - 452161..452475 (+) 315 WP_013730182.1 hypothetical protein -
  DK877_RS02405 (DK877_02460) - 452548..452982 (+) 435 WP_002937915.1 DUF1492 domain-containing protein -
  DK877_RS02410 (DK877_02465) - 453079..453426 (+) 348 WP_013730183.1 HNH endonuclease -
  DK877_RS02415 (DK877_02470) - 453515..453877 (+) 363 WP_105203945.1 hypothetical protein -
  DK877_RS02420 (DK877_02475) - 453874..455139 (+) 1266 WP_013730185.1 phage portal protein -
  DK877_RS02425 - 455132..456352 (+) 1221 WP_013730186.1 hypothetical protein -
  DK877_RS02430 (DK877_02485) - 456357..456590 (+) 234 WP_022540567.1 hypothetical protein -
  DK877_RS02435 (DK877_02490) - 456792..457994 (-) 1203 WP_308457548.1 IS110 family transposase -
  DK877_RS11100 (DK877_02495) - 458334..458589 (-) 256 Protein_444 IS110 family transposase -
  DK877_RS11105 - 458898..459185 (+) 288 Protein_445 ISL3 family transposase -
  DK877_RS02440 (DK877_02500) - 459709..460347 (-) 639 WP_009909540.1 MBL fold metallo-hydrolase -
  DK877_RS02445 (DK877_02505) - 460455..462923 (+) 2469 WP_009909541.1 bifunctional DnaQ family exonuclease/ATP-dependent helicase -

Sequence

Protein


Download         Length: 664 a.a.        Molecular weight: 71226.76 Da        Isoelectric Point: 6.5350

>NTDB_id=298472 DK877_RS02250 WP_009909429.1 432160..434154(+) (stkP) [Streptococcus suis strain ISU2414]
MIQIGKIFAGRYRIVRQIGRGGMADVYLARDLILDGEEVAVKVLRTNYQTDQIAIQRFQREARAMAELDHPNIVRISDIG
EEDGQQYLAMEYVNGLDLKRYIKENAPLSNDVAVRIMGQILLAMRMAHTRGIVHRDLKPQNVLLTSNGVAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIILFEMLTGRIPYDGDSAVTIALQHFQKPLPSVREENANVP
QALENVVLKATAKKLNERYKSVAEMYADLASALSMDRQNEPRVELEGNKVDTKTLPKLSQANVETKVPHTNSSAQVSATD
KGSGKKEVAKSGNKPVSKPRPGIRTRYKVLIGAILLTVIAAGLMFFNAPRTVTVPDVSGQTVEKATEMIEVAGLEVGNIT
EEATATVDEGLVIRTSPAAKTTRRQGSKIDIVVATAALASIPDVVDKESDTARQELEALGFQVTIKEEYSEKVAQGLVIK
TDPGANSSAEKGAKITLYVSKGVAPQVVPNVVGKSQENATQILQTAGFSIGTITQEYSSSVTAGQVISTDPVANTELAKG
SIINLVISKGKELIMPDLTSGNYTYSQARSQLQALGVNAESIEKQEDRSYYSTTSDIVIGQYPAAGATIDGTVTLYVSVA
STRTSSDSSAGSSTSTSTSTGSGQ

Nucleotide


Download         Length: 1995 bp        

>NTDB_id=298472 DK877_RS02250 WP_009909429.1 432160..434154(+) (stkP) [Streptococcus suis strain ISU2414]
ATGATTCAAATCGGTAAGATCTTTGCCGGTCGGTATCGAATCGTTCGGCAAATTGGTCGAGGCGGTATGGCAGATGTTTA
CCTAGCAAGAGATTTGATTTTAGATGGAGAAGAGGTTGCTGTTAAAGTTCTTCGGACCAACTATCAGACAGATCAAATTG
CTATCCAGCGTTTTCAACGTGAAGCGCGTGCCATGGCAGAACTTGACCATCCCAATATCGTTCGTATTTCGGACATCGGT
GAAGAAGATGGTCAACAGTATCTGGCTATGGAATATGTCAATGGCCTCGATTTAAAACGTTATATAAAAGAAAATGCACC
ACTTTCCAACGATGTTGCGGTGCGAATTATGGGACAGATTCTCCTTGCTATGCGCATGGCGCACACGAGAGGAATTGTCC
ATCGAGATTTGAAACCTCAGAACGTCCTTTTGACTTCCAATGGAGTCGCTAAAGTAACAGACTTTGGTATTGCAGTTGCC
TTTGCTGAAACGAGTTTGACACAAACCAACTCCATGTTGGGTTCTGTTCACTATCTTTCACCTGAGCAGGCGCGTGGTTC
GAAAGCGACCATTCAAAGTGATATTTATGCGATGGGAATCATCCTTTTTGAAATGTTGACGGGTCGCATTCCCTATGATG
GAGACAGTGCTGTGACGATCGCTCTTCAGCATTTCCAAAAACCTCTCCCATCTGTTAGAGAAGAGAATGCCAACGTACCT
CAGGCCTTAGAAAATGTTGTACTAAAAGCAACGGCAAAAAAATTAAACGAGCGCTATAAGTCGGTTGCAGAAATGTATGC
AGATTTAGCTTCGGCTCTATCCATGGATCGTCAGAATGAACCCAGGGTTGAACTAGAAGGGAACAAGGTTGATACAAAAA
CCTTGCCGAAACTCTCCCAAGCCAATGTTGAAACGAAAGTACCGCATACAAACAGTTCTGCTCAAGTTTCTGCGACGGAT
AAGGGGTCTGGTAAGAAAGAAGTGGCGAAGTCGGGAAATAAGCCTGTTTCAAAACCAAGGCCAGGCATACGTACACGCTA
CAAAGTCTTGATAGGAGCTATTTTGTTAACAGTCATAGCGGCTGGACTCATGTTTTTCAACGCTCCACGAACAGTTACAG
TCCCTGATGTATCTGGTCAAACCGTTGAAAAAGCTACAGAAATGATTGAAGTGGCAGGATTGGAAGTTGGAAATATCACA
GAAGAAGCGACAGCGACTGTAGATGAAGGCTTGGTAATACGGACCTCTCCGGCTGCAAAGACGACCAGACGTCAAGGGAG
TAAGATTGATATTGTAGTAGCAACGGCTGCGCTGGCATCTATTCCAGATGTGGTGGATAAGGAGTCTGATACTGCGCGGC
AGGAATTGGAGGCCCTTGGTTTCCAAGTGACAATAAAAGAAGAATATAGCGAAAAAGTTGCCCAAGGACTCGTTATCAAA
ACAGATCCAGGAGCAAATAGTTCTGCTGAGAAGGGTGCAAAAATTACCCTTTACGTTTCCAAAGGAGTGGCGCCACAAGT
TGTTCCAAACGTTGTTGGAAAAAGTCAGGAGAATGCTACTCAAATTCTTCAGACAGCAGGCTTCAGCATTGGAACCATTA
CTCAGGAATATAGCTCATCTGTTACTGCAGGTCAGGTTATCAGCACAGATCCCGTTGCCAATACAGAGTTGGCAAAAGGT
TCTATCATCAATCTAGTTATTTCAAAAGGAAAAGAATTGATTATGCCTGATTTAACATCTGGCAATTACACCTATTCACA
GGCGCGTAGTCAATTACAAGCCTTGGGTGTCAATGCGGAAAGTATTGAAAAACAAGAAGATAGAAGCTATTATTCAACGA
CAAGTGACATCGTCATTGGACAATATCCTGCTGCTGGAGCAACAATTGATGGAACAGTTACCTTGTATGTCTCTGTTGCA
TCAACCAGAACCAGTAGCGATTCTTCAGCAGGAAGTTCCACAAGTACAAGTACTTCAACAGGTAGCGGACAATAA

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(574-638)

PASTA domain (PASTA)

(372-434)

PASTA domain (PASTA)

(507-569)

PASTA domain (PASTA)

(441-501)

Protein kinase domain (Pkinase)

(12-240)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  stkP Streptococcus pneumoniae TIGR4

52.03

100

0.521
  stkP Streptococcus pneumoniae D39

52.03

100

0.521
  stkP Streptococcus pneumoniae R6

52.03

100

0.521
  stkP Streptococcus pneumoniae Rx1

51.88

100

0.52
  stkP/pknB Streptococcus salivarius strain HSISS4

51.171

90.06

0.461
  pknB Streptococcus mutans UA159

54.529

81.476

0.444

Multiple sequence alignment