Detailed information NTG0296912

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: EQH24_RS00475
• Genome accession: NZ_CP035256
• Coordinates: 79688..81841 (+)
• Length: 717 a.a.
• NCBI ID: WP_000668282.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain TVO_1901930
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 74688..86841

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH24_RS00445 (EQH24_00455)	-	75108..76277 (+)	1170	WP_023396089.1	pyridoxal phosphate-dependent aminotransferase	-
EQH24_RS00450 (EQH24_00460)	recO	76274..77044 (+)	771	WP_023396090.1	DNA repair protein RecO	Machinery gene
EQH24_RS00455 (EQH24_00465)	plsX	77041..78033 (+)	993	WP_023396091.1	phosphate acyltransferase PlsX	-
EQH24_RS00460 (EQH24_00470)	-	78039..78272 (+)	234	WP_000136446.1	acyl carrier protein	-
EQH24_RS00465 (EQH24_00475)	-	78309..78608 (+)	300	Protein_86	transposase family protein	-
EQH24_RS00470 (EQH24_00480)	cipB	78811..78969 (+)	159	WP_001093073.1	bacteriocin class II family protein	Regulator
EQH24_RS11575	-	78972..79097 (+)	126	WP_000346297.1	PncF family bacteriocin immunity protein	-
EQH24_RS00475 (EQH24_00485)	comA	79688..81841 (+)	2154	WP_000668282.1	peptide cleavage/export ABC transporter ComA	Regulator
EQH24_RS00480 (EQH24_00490)	comB	81854..83203 (+)	1350	WP_000801620.1	competence pheromone export protein ComB	Regulator
EQH24_RS00485 (EQH24_00495)	purC	83373..84080 (+)	708	WP_000043300.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
EQH24_RS11680 (EQH24_00500)	-	84091..84213 (+)	123	WP_023396093.1	hypothetical protein	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80354.38 Da
• Isoelectric Point: 6.3368

>NTDB_id=296912 EQH24_RS00475 WP_000668282.1 79688..81841(+) (comA) [Streptococcus pneumoniae strain TVO_1901930]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPHKDQKNGLLSFIPI
LVKQRGLIANIVLATLLVTLINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAALSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGEMTFKQVHYKYGYGRDVLSDINLTVPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS

Nucleotide

• Length: 2154 bp

>NTDB_id=296912 EQH24_RS00475 WP_000668282.1 79688..81841(+) (comA) [Streptococcus pneumoniae strain TVO_1901930]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAAGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTATGGTAGTTATTATTTTTTGGCTCACTTGCGAGAATTGGCTAAGACGACCATGGATGGGACGACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGCTTTGAGACACGAGCTATCAAGGCGGATATGACGCTTTTTGATTTGCCCGATTTG
ACTTTTCCTTTTGTTGCCCATGTGCTTAAGGAAGGGAAATTGCTCCACTACTATGTGGTGACTGGGCAGGATAAGGACAG
CATTCATATTGCCGATCCAGATCCTGGGGTGAAATTGACCAAACTGCCACGTGAGCGTTTTGAGGAAGAATGGACAGGAG
TGACTCTGTTTATGGCACCTAGTCCAGACTACAAGCCTCATAAGGATCAAAAGAATGGTCTGCTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCCAATATCGTTTTGGCAACACTCTTGGTAACCTTGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACGTTGGGGATTATTTCTATTGGGCTAGTCA
TCGTCTACATCCTCCAGCAAATCTTGTCTTACGCTCAGGAGTATCTCTTGCTTGTTTTGGGGCAACGCTTGTCGATTGAC
GTGATTTTGTCCTATATCAAGCATGTTTTTCACCTCCCTATGTCCTTCTTTGCGACACGCAGGACAGGGGAGATCGTGTC
TCGTTTTACAGATGCTAACAGTATCATCGATGCGCTGGCTTCGACCATCCTTTCGATTTTCCTAGATGTGTCAACGGTTG
TCATTATTTCCCTTGTTTTATTTTCACAAAATACCAATCTCTTTTTCATGACTTTATTGGCGCTTCCTATCTACACAGTG
ATTATCTTTGCCTTTATGAAGCCATTTGAAAAGATGAATCGGGACACCATGGAAGCCAATGCGGCTCTGTCTTCTTCTAT
CATTGAGGACATCAATGGTATTGAGACTATCAAGTCCTTGACCAGTGAAAGTCAGCGTTACCAAAAAATTGACAAGGAAT
TTGTGGATTATCTGAAGAAATCCTTTACCTATAGTCGAGCAGAGAGTCAGCAAAAGGCTCTGAAAAAGGTTGCCCATCTC
TTGCTTAATGTCGGCATTCTCTGGATGGGGGCTGTTCTGGTCATGGATGGCAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTGCTGGTTTACTTTACCAATCCTTTGGAAAATATCATCAATCTGCAAACCAAGCTTCAGACAGCGCAGGTTG
CCAATAACCGTCTAAATGAAGTGTATCTAGTAGCTTCTGAGTTTGAGGAGAAGAAAACAGTTGAGGATTTGAGCTTGATG
AAGGGAGAGATGACTTTCAAGCAGGTTCATTACAAGTATGGCTATGGTCGAGACGTCTTGTCGGATATCAATTTAACCGT
TCCCCAAGGGTCTAAGGTGGCTTTTGTGGGGATTTCAGGGTCAGGTAAGACGACTTTGGCCAAGATGATGGTTAATTTTT
ACGACCCAAGTCAAGGGGAGATTAGTCTGGGTGGTGTCAATCTCAATCAGATTGATAAAAAAGCCCTGCGCCAGTACATC
AACTATCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTGGAGAATCTTCTTTTGGGAGCCAAGGAGGGGACGAC
ACAGGAAGATATCTTACGGGCGGTCGAATTGGCAGAGATTCGAGAGGATATCGAGCGCATGCCACTGAATTATCAGACAG
AATTGACTTCGGATGGGGCAGGGATTTCAGGTGGTCAACGTCAGAGAATCGCTTTGGCGCGTGCTCTCTTGACAGATGCG
CCGGTCTTGATTTTGGATGAGGCGACTAGCAGTTTGGATATTTTGACAGAGAAGCGGATTGTCGATAATCTCATGGCTTT
GGACAAGACCTTGATTTTCATTGCTCACCGCTTGACTATTGCTGAGCGGACAGAGAAGGTAGTTGTCTTGGATCAGGGCA
AGATTGTCGAAGAAGGAAAGCATGCTGATTTGCTTGCACAGGGTGGCTTTTACGCCCATTTGGTCAATAGCTAG

Domains

Predicted by InterProScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter transmembrane region (ABC_membrane) (170-438)

• ABC transporter (ABC_tran) (500-650)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus pneumoniae Rx1	99.303	100	0.993
comA	Streptococcus pneumoniae D39	99.303	100	0.993
comA	Streptococcus pneumoniae R6	99.303	100	0.993
comA	Streptococcus pneumoniae TIGR4	98.884	100	0.989
comA	Streptococcus mitis SK321	98.605	100	0.986
comA	Streptococcus mitis NCTC 12261	98.605	100	0.986
comA	Streptococcus gordonii str. Challis substr. CH1	80.614	100	0.806
comA/nlmT	Streptococcus mutans UA159	64.714	100	0.647