Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   DK181_RS10740 Genome accession   NZ_CP029490
Coordinates   2196100..2197308 (+) Length   402 a.a.
NCBI ID   WP_002960389.1    Uniprot ID   U2IRH3
Organism   Streptococcus sobrinus strain SL1     
Function   require for competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2191100..2202308
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DK181_RS10720 (DK182_10720) - 2192162..2194774 (+) 2613 WP_002962171.1 YfhO family protein -
  DK181_RS10735 (DK182_10735) rlmH 2195425..2195904 (-) 480 WP_028798461.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  DK181_RS10740 (DK182_10740) htrA 2196100..2197308 (+) 1209 WP_002960389.1 S1C family serine protease Regulator
  DK181_RS10745 (DK182_10745) spo0J 2197368..2198135 (+) 768 WP_002960391.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 402 a.a.        Molecular weight: 42296.03 Da        Isoelectric Point: 7.3136

>NTDB_id=293188 DK181_RS10740 WP_002960389.1 2196100..2197308(+) (htrA) [Streptococcus sobrinus strain SL1]
MKKVKKISWKKILKPFLMLLIGFLGGLLATFVMLKMSGINTSLGKNVVSHTQYNNSSDVTKAVDKVKDAVVTVNNYQELS
DSQAKAADEAGLEKDKDGLTPVAQGSGVIYKKDGKSAYVVTNAHVVSGAKKLTLMLGGETDRSKAIKGELIGSDTYSDIA
VIKISSDKVTKVAEFADSSSVKVGETAIAIGSPLDKKFANTVTQGIISALDRTVTLTAEDGTTIQTKAFQTDAAINPGNS
GGALINIEGQVIGINSSKISLEGAEGLGFAIPSNDVVSTINQLEKNGKVSRPALGITMGDLSSASSSVKDKVDVPSDVTK
GVVVGSVQSDMPADGKLKEYDVITKIDDKDVSSVAELQEELYKHKLGDTVTLTFYRDGSKKTADIKLNKSSDDLDSSSSS
SK

Nucleotide


Download         Length: 1209 bp        

>NTDB_id=293188 DK181_RS10740 WP_002960389.1 2196100..2197308(+) (htrA) [Streptococcus sobrinus strain SL1]
TTGAAAAAAGTTAAAAAGATTTCTTGGAAAAAAATCCTAAAACCTTTCTTGATGCTACTGATTGGTTTTCTAGGTGGCTT
ATTGGCAACCTTCGTCATGCTAAAAATGAGTGGTATCAATACATCTCTGGGCAAAAATGTCGTCAGCCATACCCAATACA
ATAATTCATCTGACGTCACAAAGGCTGTAGATAAGGTTAAGGATGCTGTTGTCACAGTTAATAATTACCAAGAGCTGTCT
GATTCTCAAGCCAAGGCTGCTGATGAAGCTGGTTTGGAAAAGGATAAGGATGGCTTGACTCCAGTTGCTCAAGGTTCTGG
GGTTATCTATAAAAAAGATGGAAAAAGTGCCTATGTCGTTACTAATGCCCATGTTGTTAGTGGCGCTAAGAAACTAACTC
TCATGTTGGGTGGTGAAACTGATCGCAGTAAAGCCATCAAAGGGGAATTAATCGGTTCAGATACTTATTCCGATATTGCT
GTTATCAAGATTTCCTCTGATAAGGTGACTAAGGTAGCTGAGTTTGCTGACTCGTCATCTGTTAAGGTTGGTGAAACAGC
CATTGCTATCGGTAGCCCTTTAGACAAGAAATTTGCTAATACTGTTACTCAAGGTATTATTTCAGCTTTGGACCGAACAG
TAACTCTGACCGCTGAAGATGGAACAACAATCCAAACCAAAGCCTTCCAAACCGATGCGGCTATCAACCCTGGTAACTCA
GGCGGTGCCCTTATCAATATTGAAGGTCAAGTTATCGGTATCAATTCTAGTAAAATTTCTCTAGAGGGTGCTGAAGGTCT
CGGCTTTGCTATCCCTTCTAATGATGTTGTTTCTACTATTAATCAGTTAGAAAAGAATGGTAAGGTTAGCCGCCCAGCCC
TCGGCATTACCATGGGCGATTTAAGCAGCGCAAGCTCTTCCGTTAAGGACAAGGTTGATGTTCCTAGTGATGTTACCAAA
GGTGTTGTGGTTGGTTCTGTCCAATCCGATATGCCAGCTGATGGTAAGTTGAAAGAATACGATGTTATCACCAAGATAGA
TGATAAGGATGTTAGCTCTGTTGCTGAGTTACAAGAAGAACTTTACAAGCACAAACTTGGTGACACCGTCACCCTGACCT
TCTACCGCGACGGTAGCAAGAAGACAGCTGACATTAAATTGAATAAATCTAGCGATGATTTGGATTCATCCTCATCAAGC
AGTAAGTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(292-387)

Trypsin-like peptidase domain (Trypsin_2)

(105-254)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB U2IRH3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

56.511

100

0.572
  htrA Streptococcus gordonii str. Challis substr. CH1

54.156

98.756

0.535
  htrA Streptococcus pneumoniae D39

53.234

100

0.532
  htrA Streptococcus pneumoniae TIGR4

53.234

100

0.532
  htrA Streptococcus mitis NCTC 12261

53.234

100

0.532
  htrA Streptococcus pneumoniae R6

53.234

100

0.532
  htrA Streptococcus pneumoniae Rx1

53.234

100

0.532

Multiple sequence alignment