Detailed information NTG0293136

Bioinformatically predicted

Overview

• Name: comR/comR1
• Type: Regulator
• Locus tag: DK181_RS00270
• Genome accession: NZ_CP029490
• Coordinates: 39843..40748 (+)
• Length: 301 a.a.
• NCBI ID: WP_002959603.1
• Uniprot ID: -
• Organism: Streptococcus sobrinus strain SL1
• Function: repress natural transformation (predicted from homology) Competence regulation

Genomic Context

Location: 34843..45748

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DK181_RS00240 (DK182_00240)	-	34878..35012 (+)	135	WP_021674295.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
DK181_RS11000	-	35042..35170 (+)	129	WP_019768929.1	hypothetical protein	-
DK181_RS10765	-	35225..35368 (+)	144	WP_002959617.1	hypothetical protein	-
DK181_RS00245 (DK182_00245)	-	35630..36451 (+)	822	WP_019768928.1	ABC transporter ATP-binding protein	-
DK181_RS00250 (DK182_00250)	-	36441..37160 (+)	720	WP_002959613.1	ABC transporter permease	-
DK181_RS11005	-	37402..37530 (+)	129	WP_019768926.1	hypothetical protein	-
DK181_RS00255 (DK182_00255)	-	37661..37891 (+)	231	WP_002959611.1	hypothetical protein	-
DK181_RS00260 (DK182_00260)	-	38155..39492 (+)	1338	WP_028798494.1	lipase	-
DK181_RS00265 (DK182_00265)	-	39518..39676 (+)	159	WP_002959605.1	bacteriocin	-
DK181_RS00270 (DK182_00270)	comR/comR1	39843..40748 (+)	906	WP_002959603.1	helix-turn-helix domain-containing protein	Regulator
DK181_RS00275 (DK182_00275)	comA	41008..43125 (+)	2118	WP_002959601.1	peptide cleavage/export ABC transporter	Regulator
DK181_RS00280 (DK182_00280)	-	43319..44221 (+)	903	Protein_36	helix-turn-helix domain-containing protein	-
DK181_RS00285 (DK182_00285)	-	44351..45223 (-)	873	WP_002959599.1	helix-turn-helix domain-containing protein	-

Sequence

Protein

• Length: 301 a.a.
• Molecular weight: 35500.52 Da
• Isoelectric Point: 4.3817

>NTDB_id=293136 DK181_RS00270 WP_002959603.1 39843..40748(+) (comR/comR1) [Streptococcus sobrinus strain SL1]
MTIKADLGRRIKAERNQKKISQSSFCGDEEKLTIRQLQRIEHGQSLPTLEKLEFIADRLDIKMSDLLEGRDIQLPDDYWE
MKARIVKFPTYGDEERIQQKQNLIDEIYDKYFDSLPEDELLFLDLSENILGGIHDKNIPDIEEIYDDAFDQVLKKERFDF
NDYLYLGYFLQQCRKDSDYDYKTFKKIEQKLLKQELLADDLYNIELLATVMDAATVYAFHDDYGNIMPLLEKLNRIIEKA
QLPTYKVGLLELEAKYYIKVVEDKEKAKELYQRALMLGDILDDPTIIADVKMEMKNDGIDE

Nucleotide

• Length: 906 bp

>NTDB_id=293136 DK181_RS00270 WP_002959603.1 39843..40748(+) (comR/comR1) [Streptococcus sobrinus strain SL1]
ATGACAATAAAAGCAGATTTAGGACGACGGATTAAGGCCGAAAGAAACCAGAAAAAAATATCGCAGAGTTCATTTTGCGG
GGACGAAGAAAAGCTAACGATTCGTCAGTTGCAGCGGATTGAGCATGGCCAATCCCTACCAACTCTAGAAAAGTTGGAAT
TTATCGCTGATCGTTTGGACATTAAAATGTCTGACCTTCTGGAAGGTAGGGATATCCAATTACCGGATGACTATTGGGAA
ATGAAAGCACGGATTGTTAAATTTCCTACCTATGGAGATGAGGAAAGAATCCAGCAAAAACAGAATCTCATTGATGAAAT
TTATGATAAATACTTTGACAGTCTACCTGAGGATGAACTGCTCTTTTTGGACCTTTCAGAAAATATTCTAGGGGGTATTC
ATGACAAGAATATTCCTGATATTGAAGAAATTTATGATGATGCCTTCGATCAGGTTCTTAAAAAGGAGAGGTTTGATTTT
AACGATTACCTTTATTTGGGCTATTTTTTGCAACAGTGTCGCAAGGATTCCGATTATGATTATAAGACTTTTAAAAAAAT
TGAGCAGAAATTACTAAAGCAGGAGCTATTGGCAGATGATCTCTATAATATTGAACTTTTAGCGACAGTAATGGATGCTG
CTACTGTCTATGCTTTTCATGATGATTATGGAAATATCATGCCCTTGTTAGAAAAGCTGAATCGTATTATTGAGAAAGCT
CAACTCCCCACCTACAAGGTAGGACTTTTAGAACTTGAGGCCAAGTACTATATTAAGGTTGTTGAAGATAAAGAAAAAGC
CAAAGAACTTTACCAGCGCGCTCTGATGCTGGGAGATATTCTAGATGATCCCACCATTATTGCTGATGTTAAGATGGAAA
TGAAAAATGATGGGATAGATGAATAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (11-66)

• ComR tetratricopeptide (ComR_TPR) (75-294)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR/comR1	Streptococcus sobrinus strain NIDR 6715-7	98.671	100	0.987
comR/comR2	Streptococcus sobrinus strain NIDR 6715-7	72.333	99.668	0.721
comR	Streptococcus thermophilus LMG 18311	41.806	99.336	0.415
comR	Streptococcus salivarius strain HSISS4	41.806	99.336	0.415
comR	Streptococcus thermophilus LMD-9	41.137	99.336	0.409
comR	Streptococcus salivarius SK126	41.137	99.336	0.409