Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   DG474_RS05930 Genome accession   NZ_CP029257
Coordinates   1204145..1204819 (-) Length   224 a.a.
NCBI ID   WP_000590630.1    Uniprot ID   A0A4V0BT06
Organism   Streptococcus oralis strain CCUG 53468     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1199145..1209819
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DG474_RS05905 (DG474_06015) - 1199279..1200208 (-) 930 WP_255777651.1 peptidase U32 family protein -
  DG474_RS05910 (DG474_06020) - 1200334..1201014 (-) 681 WP_255777652.1 ABC transporter ATP-binding protein -
  DG474_RS05915 (DG474_06025) - 1201028..1202083 (-) 1056 WP_255777653.1 ABC transporter permease -
  DG474_RS05920 (DG474_06030) - 1202468..1202752 (+) 285 WP_255777655.1 DUF3270 domain-containing protein -
  DG474_RS05925 (DG474_06035) ciaH 1202818..1204155 (-) 1338 WP_042768396.1 cell wall metabolism sensor histidine kinase WalK Regulator
  DG474_RS05930 (DG474_06040) ciaR 1204145..1204819 (-) 675 WP_000590630.1 two-component system response regulator CiaR Regulator
  DG474_RS05935 (DG474_06045) - 1204929..1207475 (-) 2547 WP_255777657.1 M1 family metallopeptidase -
  DG474_RS05940 (DG474_06050) - 1207596..1208036 (-) 441 WP_125420935.1 ASCH domain-containing protein -
  DG474_RS05945 (DG474_06055) - 1208005..1208881 (-) 877 Protein_1121 putative PEP-binding protein -
  DG474_RS05950 (DG474_06060) - 1208859..1209359 (-) 501 WP_255777658.1 NUDIX hydrolase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25479.29 Da        Isoelectric Point: 4.2660

>NTDB_id=291422 DG474_RS05930 WP_000590630.1 1204145..1204819(-) (ciaR) [Streptococcus oralis strain CCUG 53468]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGDIVVNLSTNEVKVEDTPVELLGKEFELLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTAFAENLQTLRSVGYILKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=291422 DG474_RS05930 WP_000590630.1 1204145..1204819(-) (ciaR) [Streptococcus oralis strain CCUG 53468]
ATGATAAAAATCTTATTAGTAGAAGACGACCTAGGCCTGTCAAACTCAGTATTTGACTTTTTGGATGATTTTGCAGATGT
CATGCAGGTTTTTGATGGAGAAGAAGGTCTTTACGAAGCTGAAAGTGGCGTCTATGACTTGATTTTGCTTGACCTGATGT
TGCCTGAAAAAAATGGCTTCCAAGTTCTGAAAGAATTGCGTGAAAAAGGAATCACGACACCAGTCCTTATCATGACTGCC
AAAGAGAGTTTGGATGACAAGGGACACGGTTTTGAGCTTGGAGCGGATGACTACCTCACCAAACCTTTCTACCTTGAAGA
ACTCAAAATGCGGATCCAAGCCCTTCTCAAACGTTCAGGTAAGTTTAACGAAAACACCTTGACCTATGGAGATATTGTCG
TTAACCTTTCAACGAATGAAGTGAAGGTGGAAGATACTCCTGTGGAACTACTCGGAAAAGAGTTTGAGTTATTGGTTTAT
TTCCTTCAAAATCAAAATGTTATTCTTCCTAAGACGCAAATTTTTGACCGTCTATGGGGATTTGATAGCGATACGACGAT
TTCCGTTGTAGAAGTCTATGTCTCAAAAGTTCGTAAGAAATTGAAGGGAACAGCCTTTGCTGAAAATCTTCAAACCTTGC
GTAGTGTCGGGTATATTTTAAAAGATGTTCAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4V0BT06

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae TIGR4

97.768

100

0.978
  ciaR Streptococcus pneumoniae D39

97.768

100

0.978
  ciaR Streptococcus pneumoniae R6

97.768

100

0.978
  ciaR Streptococcus pneumoniae Rx1

97.768

100

0.978
  ciaR Streptococcus mutans UA159

87.5

100

0.875
  vicR Streptococcus mutans UA159

36.481

100

0.379
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.283

100

0.366

Multiple sequence alignment