Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   DG474_RS05925 Genome accession   NZ_CP029257
Coordinates   1202818..1204155 (-) Length   445 a.a.
NCBI ID   WP_042768396.1    Uniprot ID   A0A1X1I0U4
Organism   Streptococcus oralis strain CCUG 53468     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1197818..1209155
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DG474_RS05900 (DG474_06010) rpiA 1198490..1199173 (-) 684 WP_049505712.1 ribose-5-phosphate isomerase RpiA -
  DG474_RS05905 (DG474_06015) - 1199279..1200208 (-) 930 WP_255777651.1 peptidase U32 family protein -
  DG474_RS05910 (DG474_06020) - 1200334..1201014 (-) 681 WP_255777652.1 ABC transporter ATP-binding protein -
  DG474_RS05915 (DG474_06025) - 1201028..1202083 (-) 1056 WP_255777653.1 ABC transporter permease -
  DG474_RS05920 (DG474_06030) - 1202468..1202752 (+) 285 WP_255777655.1 DUF3270 domain-containing protein -
  DG474_RS05925 (DG474_06035) ciaH 1202818..1204155 (-) 1338 WP_042768396.1 cell wall metabolism sensor histidine kinase WalK Regulator
  DG474_RS05930 (DG474_06040) ciaR 1204145..1204819 (-) 675 WP_000590630.1 two-component system response regulator CiaR Regulator
  DG474_RS05935 (DG474_06045) - 1204929..1207475 (-) 2547 WP_255777657.1 M1 family metallopeptidase -
  DG474_RS05940 (DG474_06050) - 1207596..1208036 (-) 441 WP_125420935.1 ASCH domain-containing protein -
  DG474_RS05945 (DG474_06055) - 1208005..1208881 (-) 877 Protein_1121 putative PEP-binding protein -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 50817.50 Da        Isoelectric Point: 9.5838

>NTDB_id=291421 DG474_RS05925 WP_042768396.1 1202818..1204155(-) (ciaH) [Streptococcus oralis strain CCUG 53468]
MFNKLKKTWYADDFSYFIRNFGVFTLIFSAMTLIILQVMHSSLYTSVDEKLQALSSSPQAVIQLALNRATEEVKDIQPAT
ADANKAEIKPNVSSNTEVLLFDKDFNQLLLGNRFLGLDKIKLDKKELNHIRQIQVVNSYGQEETYRMILMETNSSSVSSN
VKYAAVLINTSQLEQISQNHEHLIVVVMASFWLLSLIASVYLARVSVKPLLESMQKQKSFVENASHELRTPLAVLQNRLE
NLFRKPEATIMESSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPEIAEVSPQFFKTTFANYELIASENDRIFEYENRI
YRPFMTDQLLLKQLMTILFDNAIKYTEEDGKIEFVVHATDRHLYLTVTDNGIGISAADKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALRGTISVKDNKPRGTIFEVKIAIQSPSKRKNK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=291421 DG474_RS05925 WP_042768396.1 1202818..1204155(-) (ciaH) [Streptococcus oralis strain CCUG 53468]
ATGTTCAATAAACTAAAAAAAACATGGTATGCGGATGATTTCAGCTATTTCATTCGAAACTTTGGAGTGTTCACCCTGAT
CTTCTCTGCTATGACCTTGATTATCCTCCAGGTCATGCACTCGAGTCTCTATACTTCTGTAGATGAAAAACTCCAAGCCC
TTAGTAGCAGTCCCCAAGCGGTTATCCAGTTAGCCTTGAATCGGGCGACTGAAGAGGTCAAGGATATTCAACCAGCAACA
GCGGATGCCAACAAGGCTGAAATCAAGCCCAATGTCAGCTCCAATACGGAAGTCTTGCTCTTTGACAAGGATTTTAACCA
ACTCTTATTGGGGAATCGCTTTTTAGGTTTGGACAAGATCAAGCTGGACAAAAAGGAGTTGAATCACATTCGCCAAATCC
AAGTTGTCAATAGCTACGGTCAGGAAGAAACCTATCGGATGATTTTGATGGAAACCAACTCTTCCTCGGTATCAAGTAAC
GTCAAGTATGCGGCGGTTTTAATCAATACCAGCCAGCTCGAGCAAATCAGCCAAAATCACGAGCATTTAATTGTTGTAGT
CATGGCTAGTTTCTGGCTCCTGTCTTTAATTGCCAGTGTTTACCTAGCACGTGTCAGTGTCAAACCCTTGCTGGAAAGTA
TGCAAAAGCAGAAGTCCTTTGTTGAAAATGCAAGTCACGAACTGAGAACGCCTTTGGCCGTTTTACAAAATCGTTTAGAA
AATCTCTTTCGAAAACCAGAGGCAACGATTATGGAATCCAGCGAAAGTATCGCTTCGAGTCTTGAAGAAGTTCGCAACAT
GCGCTTCCTTACGACCAATCTTCTCAACCTTGCACGTCGAGATGATGGAATCAAACCAGAAATAGCAGAAGTATCACCAC
AGTTCTTTAAGACGACTTTTGCTAACTATGAGTTGATTGCTTCTGAAAATGATCGTATTTTTGAGTATGAAAATCGGATT
TATCGTCCCTTCATGACCGATCAGTTGCTCCTAAAACAGCTCATGACCATCTTATTTGACAATGCCATCAAGTATACTGA
AGAAGATGGGAAAATTGAGTTTGTAGTTCATGCTACAGATCGCCACCTCTATCTAACAGTAACGGATAACGGAATTGGAA
TCTCAGCTGCTGACAAGAAGAAAATCTTTGACCGATTTTACCGTGTGGACAAGGCGAGAACCCGTCAGAAAGGTGGCTTT
GGTCTTGGACTATCTTTAGCCAAGCAGATCGTAGATGCATTAAGAGGAACGATTAGCGTAAAAGATAACAAACCTAGAGG
AACAATTTTTGAAGTTAAGATCGCTATTCAATCGCCTTCAAAACGTAAGAATAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)

His Kinase A (phospho-acceptor) domain (HisKA)

(218-283)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1X1I0U4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

83.973

99.551

0.836
  ciaH Streptococcus pneumoniae D39

83.973

99.551

0.836
  ciaH Streptococcus pneumoniae R6

83.973

99.551

0.836
  ciaH Streptococcus pneumoniae TIGR4

83.973

99.551

0.836
  ciaH Streptococcus mutans UA159

54.795

98.427

0.539

Multiple sequence alignment