Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   DG474_RS04685 Genome accession   NZ_CP029257
Coordinates   949835..950542 (+) Length   235 a.a.
NCBI ID   WP_000722056.1    Uniprot ID   A0A3R9IRL2
Organism   Streptococcus oralis strain CCUG 53468     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 944835..955542
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DG474_RS04660 (DG474_04760) - 945133..945804 (+) 672 WP_000151555.1 GTP pyrophosphokinase family protein -
  DG474_RS04665 (DG474_04765) - 945788..946606 (+) 819 WP_000799063.1 NAD kinase -
  DG474_RS04670 (DG474_04770) - 946603..947499 (+) 897 WP_255778924.1 RluA family pseudouridine synthase -
  DG474_RS04675 (DG474_04775) pta 947543..948517 (+) 975 WP_049484120.1 phosphate acetyltransferase -
  DG474_RS04680 (DG474_04780) mutY 948600..949778 (+) 1179 WP_255778925.1 A/G-specific adenine glycosylase -
  DG474_RS04685 (DG474_04785) micA 949835..950542 (+) 708 WP_000722056.1 response regulator YycF Regulator
  DG474_RS04690 (DG474_04790) micB 950535..951884 (+) 1350 WP_000568720.1 cell wall metabolism sensor histidine kinase VicK Regulator
  DG474_RS04695 (DG474_04795) vicX 951886..952695 (+) 810 WP_001290606.1 MBL fold metallo-hydrolase Regulator
  DG474_RS04700 (DG474_04800) - 952783..953556 (+) 774 WP_000824597.1 potassium channel family protein -
  DG474_RS04705 (DG474_04805) - 953593..953940 (-) 348 WP_070800487.1 PedC/BrcD family bacteriocin maturation disulfide isomerase -

Sequence

Protein


Download         Length: 235 a.a.        Molecular weight: 27032.88 Da        Isoelectric Point: 4.6177

>NTDB_id=291415 DG474_RS04685 WP_000722056.1 949835..950542(+) (micA) [Streptococcus oralis strain CCUG 53468]
MKKILIVDDEKPISDIIKFNMAKEGYEVVTAFNGREAIELFEAEQPDIIILDLMLPEIDGLEVAKAIRKTSSVPIIMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRTDLVSVDNQESDEKKTQPLQIGDLEIVPDAYVAKKYGEELDL
THREFELLYHLASHIGQVITREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMRNND

Nucleotide


Download         Length: 708 bp        

>NTDB_id=291415 DG474_RS04685 WP_000722056.1 949835..950542(+) (micA) [Streptococcus oralis strain CCUG 53468]
ATGAAAAAAATATTAATTGTAGATGATGAGAAACCAATCTCAGATATTATTAAGTTTAATATGGCCAAGGAAGGTTATGA
AGTTGTAACAGCCTTCAATGGTCGTGAGGCAATCGAGCTATTTGAAGCTGAGCAACCGGATATTATTATCCTCGACTTGA
TGCTACCTGAAATTGATGGTTTAGAAGTTGCTAAAGCTATTCGTAAGACTAGTAGCGTGCCGATTATCATGCTATCAGCT
AAGGATAGCGAATTTGACAAGGTTATTGGTTTAGAGTTAGGTGCAGATGATTATGTTACAAAACCTTTCTCAAACCGTGA
GTTGCAGGCTCGTGTTAAGGCCCTTCTTCGTCGTACCGATCTAGTTTCAGTAGATAACCAAGAGTCTGATGAGAAGAAGA
CGCAACCTTTACAAATTGGTGATTTGGAAATCGTTCCAGATGCTTACGTGGCAAAGAAATATGGTGAGGAATTAGATTTA
ACCCACCGTGAGTTTGAACTCTTGTATCACTTGGCGTCTCATATTGGTCAAGTGATTACACGTGAACACTTGCTTGAGAC
TGTATGGGGTTATGACTATTTTGGTGATGTTCGTACTGTGGACGTGACCATTAGACGCTTGCGTGAGAAAATAGAAGATA
CTCCAAGTCGTCCAGAGTACATTCTCACACGTCGTGGTGTTGGATACTATATGAGAAATAATGATTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(155-230)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A3R9IRL2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

92.308

99.574

0.919
  vicR Streptococcus mutans UA159

77.447

100

0.774
  covR Streptococcus salivarius strain HSISS4

44.156

98.298

0.434
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.29

98.298

0.426
  scnR Streptococcus mutans UA159

37.179

99.574

0.37

Multiple sequence alignment