Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   DG474_RS00200 Genome accession   NZ_CP029257
Coordinates   33093..35246 (+) Length   717 a.a.
NCBI ID   WP_255778243.1    Uniprot ID   -
Organism   Streptococcus oralis strain CCUG 53468     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 28093..40246
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DG474_RS00160 (DG474_00155) - 28485..29654 (+) 1170 WP_200370601.1 pyridoxal phosphate-dependent aminotransferase -
  DG474_RS00165 (DG474_00160) recO 29651..30421 (+) 771 WP_255778240.1 DNA repair protein RecO -
  DG474_RS00170 (DG474_00165) plsX 30418..31410 (+) 993 WP_255778241.1 phosphate acyltransferase PlsX -
  DG474_RS00175 (DG474_00170) - 31416..31652 (+) 237 WP_000136435.1 acyl carrier protein -
  DG474_RS00180 (DG474_00175) - 32088..32276 (+) 189 WP_049501355.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  DG474_RS00185 (DG474_00180) - 32294..32461 (+) 168 WP_255778242.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  DG474_RS00190 (DG474_00185) - 32471..32659 (+) 189 WP_000722238.1 hypothetical protein -
  DG474_RS00200 (DG474_00195) comA 33093..35246 (+) 2154 WP_255778243.1 peptide cleavage/export ABC transporter ComA Regulator
  DG474_RS00205 (DG474_00200) comB 35259..36608 (+) 1350 WP_255778244.1 competence pheromone export protein ComB Regulator
  DG474_RS00210 (DG474_00205) purC 36777..37484 (+) 708 WP_000043287.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80287.51 Da        Isoelectric Point: 6.7020

>NTDB_id=291385 DG474_RS00200 WP_255778243.1 33093..35246(+) (comA) [Streptococcus oralis strain CCUG 53468]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYSLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVIGQDKKHIHIADPDPGVKLTKISRERFAQEWTGVSLFMAPSPDYNPHKEKKQGLLSFLPI
LLKQRGLIANIVLATLLVTLINIVGSYYLQSIIDSYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLILGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTILIISLVLFSQNITLFFISLLALPIYTA
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVAYLKKSFAYSRAESQQKALKKVAQL
LLNVAVLWLGAILVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSMM
KGDMTFKQVHYKYGYGRDVLSDINLTIPQGSKMAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQFI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGTHADLLAQDGFYAHLVNS

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=291385 DG474_RS00200 WP_255778243.1 33093..35246(+) (comA) [Streptococcus oralis strain CCUG 53468]
ATGAAATTTGGGAAAAGGCACTATCGTCCCCAGGTGGATCAGATGGATTGTGGCGTGGCTTCCTTGGCTATGGTCTTTGG
CTACTACGGTAGTTATTACTCCTTGGCTCATCTACGAGAGTTAGCCAAGACGACCATGGATGGGACGACCGCTTTGGGAC
TTGTAAAGGTAGCAGAGGAGATTGGGTTTGAGACGCGGGCTATAAAGGCGGATATGACGCTCTTTGATTTGCCAGATTTG
ACCTTTCCTTTTGTGGCTCATGTGCTCAAGGAAGGGAAGTTGCTCCACTACTATGTGGTGATAGGTCAGGATAAAAAGCA
CATTCATATCGCTGATCCAGATCCTGGTGTCAAGCTGACCAAGATTTCCCGTGAGCGATTTGCGCAAGAATGGACAGGGG
TCAGTCTCTTTATGGCTCCGTCTCCAGACTATAACCCCCATAAGGAGAAAAAACAAGGACTCTTATCATTTTTACCTATC
TTGCTCAAACAGCGGGGCTTGATTGCTAATATCGTTTTGGCAACACTCTTGGTAACCCTGATCAATATCGTGGGCTCCTA
CTATCTTCAGTCCATCATTGACAGTTACGTACCAGACCAGATGCGCTCGACACTGGGTATTATCTCTATTGGGCTGGTCA
TCGTCTATATTCTCCAGCAGATTTTGTCCTATGCCCAGGAATATCTCCTACTAATCCTTGGGCAACGTCTGTCAATTGAT
GTGATTTTGTCCTACATCAAGCATGTTTTTCACCTACCGATGTCCTTTTTCGCGACACGCAGGACAGGAGAGATTGTATC
TCGTTTTACGGATGCTAACAGTATCATCGATGCGCTGGCATCGACTATTCTGTCGATTTTCCTAGATGTGTCGACGATTT
TGATTATCTCGCTTGTCTTGTTTTCACAAAATATAACGCTCTTTTTCATTAGTCTGCTTGCACTTCCCATTTATACAGCG
ATTATCTTTGCCTTTATGAAGCCTTTTGAAAAGATGAATCGGGACACTATGGAAGCCAATGCAGTTCTGTCTTCTTCTAT
TATCGAGGACATCAACGGTATTGAGACTATTAAATCTTTGACCAGTGAAAGTCAGCGTTACCAAAAGATTGACAAGGAAT
TTGTAGCTTATCTGAAAAAATCCTTTGCCTATAGTCGGGCAGAAAGTCAGCAAAAGGCTCTGAAAAAAGTTGCCCAGCTT
TTGCTCAATGTTGCCGTTCTCTGGCTGGGAGCTATTCTTGTCATGGATGGGAAAATGAGTTTGGGCCAGCTGATCACTTA
TAACACCCTGCTCGTTTACTTTACCAATCCTTTGGAAAATATCATCAACCTACAAACCAAACTTCAGACAGCGCAGGTCG
CCAATAACCGTCTTAACGAGGTTTATCTAGTAGCTTCGGAGTTTGAGGAGAAGAAAACGGTAGAAGATTTGAGCATGATG
AAAGGTGATATGACCTTTAAACAAGTTCACTATAAGTATGGCTATGGGCGTGATGTCTTGTCGGATATCAATTTGACCAT
TCCGCAAGGGTCTAAGATGGCTTTTGTGGGGATTTCAGGTTCGGGTAAGACCACCTTAGCCAAAATGATGGTTAATTTTT
ACGACCCAAGTCAGGGAGAGATTAGTCTGGGTGGTGTCAATCTCAATCAGATTGATAAAAAAGCTCTGCGCCAGTTTATC
AACTATCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTGGAGAATCTTCTTTTGGGAGCTAAGGAGGGAACGAC
TCAGGAAGATATCTTACGGGCAGTTGAATTAGCAGAGATTAGGGAGGATATTGAGCGCATGCCACTGAATTACCAGACAG
AATTGACTTCGGATGGGGCAGGGATCTCAGGTGGTCAACGTCAGAGAATTGCTCTGGCGCGTGCTCTCTTGACAGATGCG
CCGGTCTTGATTTTGGATGAGGCAACTAGTAGTTTGGATATTTTGACAGAGAAGCGGATTGTTGATAATCTCATGGCTTT
GGACAAGACCTTGATTTTCATCGCCCATCGCTTGACCATCGCTGAGCGGACAGAGAAGGTTGTTGTCTTGGATCAGGGCA
AGATTGTCGAAGAAGGTACCCATGCAGACTTGCTTGCACAGGATGGCTTTTACGCCCATTTGGTGAATAGCTAG

Domains

Predicted by InterproScan.

ABC transporter transmembrane region (ABC_membrane)

(170-438)

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter (ABC_tran)

(500-650)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus mitis NCTC 12261

94.979

100

0.95
  comA Streptococcus pneumoniae Rx1

94.7

100

0.947
  comA Streptococcus pneumoniae D39

94.7

100

0.947
  comA Streptococcus pneumoniae R6

94.7

100

0.947
  comA Streptococcus mitis SK321

94.421

100

0.944
  comA Streptococcus pneumoniae TIGR4

94.282

100

0.943
  comA Streptococcus gordonii str. Challis substr. CH1

80.335

100

0.803
  comA/nlmT Streptococcus mutans UA159

64.296

100

0.643

Multiple sequence alignment