Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SK637_RS03840 Genome accession   NZ_CP028415
Coordinates   697460..698134 (+) Length   224 a.a.
NCBI ID   WP_000590639.1    Uniprot ID   A0A419RXM2
Organism   Streptococcus mitis strain SK637     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 692460..703134
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SK637_RS03820 (SK637_00742) - 692919..693422 (+) 504 WP_033688603.1 NUDIX hydrolase -
  SK637_RS03825 - 693400..694301 (+) 902 Protein_679 putative PEP-binding protein -
  SK637_RS03830 (SK637_00745) - 694243..694683 (+) 441 WP_033688605.1 ASCH domain-containing protein -
  SK637_RS03835 (SK637_00746) - 694805..697351 (+) 2547 WP_033688607.1 M1 family metallopeptidase -
  SK637_RS03840 (SK637_00747) ciaR 697460..698134 (+) 675 WP_000590639.1 two-component system response regulator CiaR Regulator
  SK637_RS03845 (SK637_00748) ciaH 698124..699458 (+) 1335 WP_033688608.1 two-component system sensor histidine kinase CiaH Regulator
  SK637_RS03850 (SK637_00749) - 699492..699779 (-) 288 WP_033688610.1 DUF3270 domain-containing protein -
  SK637_RS03855 (SK637_00750) - 699919..700848 (+) 930 WP_033688612.1 peptidase U32 family protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25466.29 Da        Isoelectric Point: 4.3283

>NTDB_id=284702 SK637_RS03840 WP_000590639.1 697460..698134(+) (ciaR) [Streptococcus mitis strain SK637]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGYILKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=284702 SK637_RS03840 WP_000590639.1 697460..698134(+) (ciaR) [Streptococcus mitis strain SK637]
ATGATAAAAATCTTATTGGTTGAGGATGATCTAGGCCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCGGATGT
CATGCAGGTATTTGATGGGGAAGAAGGTCTCTACGAAGCTGAAAGTGGCGTCTATGACTTGATTTTGCTCGATTTAATGT
TACCTGAAAAAAATGGCTTCCAAGTCTTGAAAGAATTGCGTGAAAAGGGAATTACGACACCAGTTCTGATTATGACTGCC
AAGGAAAGCTTGGATGACAAGGGACATGGATTTGAATTGGGAGCAGATGATTATCTGACTAAACCTTTCTACCTAGAAGA
ACTCAAAATGCGAATTCAAGCCCTTCTCAAACGTTCAGGTAAATTTAATGAAAATACCTTGACTTATGGAAATATTGTGG
TTAATTTGTCAACCAATACCGTTAAAGTCGAAGATACTCCTGTCGAATTGCTGGGAAAAGAGTTCGACTTACTGGTTTAT
TTCCTTCAAAATCAAAATGTTATTTTGCCTAAGACTCAGATTTTTGATCGGCTATGGGGATTTGATAGTGACACAACGAT
TTCAGTTGTCGAAGTTTATGTTTCTAAAGTCCGTAAGAAATTAAAAGGAACCACTTTTGCAGAGAACTTGCAAACCTTGC
GCAGTGTTGGGTATATTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A419RXM2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

99.554

100

0.996
  ciaR Streptococcus pneumoniae D39

99.554

100

0.996
  ciaR Streptococcus pneumoniae R6

99.554

100

0.996
  ciaR Streptococcus pneumoniae TIGR4

99.554

100

0.996
  ciaR Streptococcus mutans UA159

88.839

100

0.888
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.726

100

0.371
  vicR Streptococcus mutans UA159

35.622

100

0.371

Multiple sequence alignment